Interleukin-10

"Interleukin-10" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus, MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure, which enables searching at various levels of specificity.

MeSH information

Definition | Details | More General Concepts | Related Concepts | More Specific Concepts

A cytokine produced by a variety of cell types, including T-LYMPHOCYTES; MONOCYTES; DENDRITIC CELLS; and EPITHELIAL CELLS that exerts a variety of effects on immunoregulation and INFLAMMATION. Interleukin-10 combines with itself to form a homodimeric molecule that is the biologically active form of the protein.

Descriptor ID	D016753
MeSH Number(s)	D12.644.276.374.465.510 D12.776.467.374.465.510 D23.529.374.465.510
Concept/Terms	Interleukin-10 Interleukin-10 Interleukin 10 IL10 IL-10 CSIF-10 Cytokine Synthesis Inhibitory Factor

Below are MeSH descriptors whose meaning is more general than "Interleukin-10".

Chemicals and Drugs [D]
Amino Acids, Peptides, and Proteins [D12]
Peptides [D12.644]
Intercellular Signaling Peptides and Proteins [D12.644.276]
Cytokines [D12.644.276.374]
Interleukins [D12.644.276.374.465]
Interleukin-10 [D12.644.276.374.465.510]
Proteins [D12.776]
Intercellular Signaling Peptides and Proteins [D12.776.467]
Cytokines [D12.776.467.374]
Interleukins [D12.776.467.374.465]
Interleukin-10 [D12.776.467.374.465.510]
Biological Factors [D23]
Intercellular Signaling Peptides and Proteins [D23.529]
Cytokines [D23.529.374]
Interleukins [D23.529.374.465]
Interleukin-10 [D23.529.374.465.510]

Below are MeSH descriptors whose meaning is related to "Interleukin-10".

Below are MeSH descriptors whose meaning is more specific than "Interleukin-10".

publications

Timeline | Most Recent

This graph shows the total number of publications written about "Interleukin-10" by people in this website by year, and whether "Interleukin-10" was a major or minor topic of these publications.

Bar chart showing 66 publications over 23 distinct years, with a maximum of 6 publications in 2010

To see the data from this visualization as text, click here.

Year	Major Topic	Minor Topic	Total
1996	1	0	1
1998	0	3	3
1999	1	1	2
2000	0	1	1
2001	0	1	1
2002	2	2	4
2005	2	1	3
2006	1	1	2
2007	1	2	3
2008	1	3	4
2009	3	2	5
2010	3	3	6
2011	1	1	2
2013	3	1	4
2014	2	2	4
2015	2	1	3
2016	1	3	4
2017	0	2	2
2018	0	4	4
2020	1	1	2
2021	2	1	3
2023	0	2	2
2025	1	0	1

Below are the most recent publications written about "Interleukin-10" by people in Profiles.

Muralidharan J, Eswaran M, Bae S, Singh S, Mir H. Elevated CCL20 and IL-10 enhance 5-fluorouracil tolerance in colon cancer. Biomed Pharmacother. 2025 Aug; 189:118258.

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Shao TY, Jiang TT, Stevens J, Russi AE, Troutman TD, Bernieh A, Pham G, Erickson JJ, Eshleman EM, Alenghat T, Jameson SC, Hogquist KA, Weaver CT, Haslam DB, Deshmukh H, Way SS. Kruppel-like factor 2+ CD4 T?cells avert microbiota-induced intestinal inflammation. Cell Rep. 2023 11 28; 42(11):113323.

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Sun C, Rahman MSU, Enkhjargal B, Peng J, Zhou K, Xie Z, Wu L, Zhang T, Zhu Q, Tang J, Zeng Y, Zhang JH, Xu S. Osteopontin modulates microglial activation states and attenuates inflammatory responses after subarachnoid hemorrhage in rats. Exp Neurol. 2024 01; 371:114585.

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Atwater AQ, Immergluck LC, Davidson AJ, Castanon-Cervantes O. Shift Work Predicts Increases in Lipopolysaccharide-Binding Protein, Interleukin-10, and Leukocyte Counts in a Cross-Sectional Study of Healthy Volunteers Carrying Low-Grade Systemic Inflammation. Int J Environ Res Public Health. 2021 12 14; 18(24).

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Diorio C, Shraim R, Vella LA, Giles JR, Baxter AE, Oldridge DA, Canna SW, Henrickson SE, McNerney KO, Balamuth F, Burudpakdee C, Lee J, Leng T, Farrel A, Lambert MP, Sullivan KE, Wherry EJ, Teachey DT, Bassiri H, Behrens EM. Proteomic profiling of MIS-C patients indicates heterogeneity relating to interferon gamma dysregulation and vascular endothelial dysfunction. Nat Commun. 2021 12 10; 12(1):7222.

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Chauss D, Freiwald T, McGregor R, Yan B, Wang L, Nova-Lamperti E, Kumar D, Zhang Z, Teague H, West EE, Vannella KM, Ramos-Benitez MJ, Bibby J, Kelly A, Malik A, Freeman AF, Schwartz DM, Portilla D, Chertow DS, John S, Lavender P, Kemper C, Lombardi G, Mehta NN, Cooper N, Lionakis MS, Laurence A, Kazemian M, Afzali B. Autocrine vitamin D signaling switches off pro-inflammatory programs of TH1 cells. Nat Immunol. 2022 01; 23(1):62-74.

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Kurtz JR, Nieves W, Bauer DL, Israel KE, Adcox HE, Gunn JS, Morici LA, McLachlan JB. Salmonella Persistence and Host Immunity Are Dictated by the Anatomical Microenvironment. Infect Immun. 2020 07 21; 88(8).

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Abbas M, Mason T, Ibad A, Khraiwesh M, Apprey V, Kanaan Y, Wilson B, Dunston G, Ricks-Santi L, Brim H. Genetic Polymorphisms in IL-10 Promoter Are Associated With Smoking and Prostate Cancer Risk in African Americans. Anticancer Res. 2020 Jan; 40(1):27-34.

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Lima MP, Costa LE, Lage DP, Dias DS, Ribeiro PAF, Machado AS, Ramos FF, Salles BCS, Fagundes MI, Carvalho GB, Franklin ML, Ch?vez-Fumagalli MA, Machado-de-?vila RA, Menezes-Souza D, Duarte MC, Teixeira AL, Gon?alves DU, Coelho EAF. Diagnostic application of recombinant Leishmania proteins and evaluation of their in vitro immunogenicity after stimulation of immune cells collected from tegumentary leishmaniasis patients and healthy individuals. Cell Immunol. 2018 12; 334:61-69.

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Lainez NM, Jonak CR, Nair MG, Ethell IM, Wilson EH, Carson MJ, Coss D. Diet-Induced Obesity Elicits Macrophage Infiltration and Reduction in Spine Density in the Hypothalami of Male but Not Female Mice. Front Immunol. 2018; 9:1992.

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