Chemokine CXCL12

"Chemokine CXCL12" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus, MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure, which enables searching at various levels of specificity.

MeSH information

Definition | Details | More General Concepts | Related Concepts | More Specific Concepts

A CXC chemokine that is chemotactic for T-LYMPHOCYTES and MONOCYTES. It has specificity for CXCR4 RECEPTORS. Two isoforms of CXCL12 are produced by alternative mRNA splicing.

Descriptor ID	D054377
MeSH Number(s)	D12.644.276.374.200.120.600 D12.776.467.374.200.120.600 D23.125.300.120.600 D23.469.200.120.600 D23.529.374.200.120.600
Concept/Terms	Chemokine CXCL12 Chemokine CXCL12 CXCL12, Chemokine Stromal Cell-Derived Factor 1 Stromal Cell Derived Factor 1 CXCL12 Chemokine Chemokine, CXCL12 Chemokine (C-X-C Motif) Ligand 12 Pre-B-Cell Growth-Stimulating Factor Growth-Stimulating Factor, Pre-B-Cell Pre B Cell Growth Stimulating Factor Stromal Cell-Derived Factor-1alpha Stromal Cell-Derived Factor-1alpha Stromal Cell Derived Factor 1alpha SDF-1alpha SDF 1alpha Stromal Cell-Derived Factor-1beta Stromal Cell-Derived Factor-1beta Cell-Derived Factor-1beta, Stromal Stromal Cell Derived Factor 1beta SDF-1beta SDF 1beta SDF1-3'A SDF1-3'A SDF1 3'A

Below are MeSH descriptors whose meaning is more general than "Chemokine CXCL12".

Chemicals and Drugs [D]
Amino Acids, Peptides, and Proteins [D12]
Peptides [D12.644]
Intercellular Signaling Peptides and Proteins [D12.644.276]
Cytokines [D12.644.276.374]
Chemokines [D12.644.276.374.200]
Chemokines, CXC [D12.644.276.374.200.120]
Chemokine CXCL12 [D12.644.276.374.200.120.600]
Proteins [D12.776]
Intercellular Signaling Peptides and Proteins [D12.776.467]
Cytokines [D12.776.467.374]
Chemokines [D12.776.467.374.200]
Chemokines, CXC [D12.776.467.374.200.120]
Chemokine CXCL12 [D12.776.467.374.200.120.600]
Biological Factors [D23]
Chemotactic Factors [D23.125]
Chemokines [D23.125.300]
Chemokines, CXC [D23.125.300.120]
Chemokine CXCL12 [D23.125.300.120.600]
Inflammation Mediators [D23.469]
Chemokines [D23.469.200]
Chemokines, CXC [D23.469.200.120]
Chemokine CXCL12 [D23.469.200.120.600]
Intercellular Signaling Peptides and Proteins [D23.529]
Cytokines [D23.529.374]
Chemokines [D23.529.374.200]
Chemokines, CXC [D23.529.374.200.120]
Chemokine CXCL12 [D23.529.374.200.120.600]

Below are MeSH descriptors whose meaning is related to "Chemokine CXCL12".

Below are MeSH descriptors whose meaning is more specific than "Chemokine CXCL12".

publications

Timeline | Most Recent

This graph shows the total number of publications written about "Chemokine CXCL12" by people in this website by year, and whether "Chemokine CXCL12" was a major or minor topic of these publications.

Bar chart showing 25 publications over 15 distinct years, with a maximum of 4 publications in 2018

To see the data from this visualization as text, click here.

Year	Major Topic	Minor Topic	Total
1998	0	2	2
1999	0	1	1
2000	0	1	1
2004	0	2	2
2007	0	2	2
2008	2	0	2
2009	0	1	1
2010	1	1	2
2011	1	0	1
2012	1	0	1
2013	1	1	2
2014	0	1	1
2015	0	1	1
2018	3	1	4
2019	0	2	2

Below are the most recent publications written about "Chemokine CXCL12" by people in Profiles.

Harbuzariu A, Pitts S, Cespedes JC, Harp KO, Nti A, Shaw AP, Liu M, Stiles JK. Modelling heme-mediated brain injury associated with cerebral malaria in human brain cortical organoids. Sci Rep. 2019 12 16; 9(1):19162.

View in: PubMed
LaRocca TJ, Altman P, Jarrah AA, Gordon R, Wang E, Hadri L, Burke MW, Haddad GE, Hajjar RJ, Tarzami ST. CXCR4 Cardiac Specific Knockout Mice Develop a Progressive Cardiomyopathy. Int J Mol Sci. 2019 May 08; 20(9).

View in: PubMed
Caggia S, Chunduri H, Millena AC, Perkins JN, Venugopal SV, Vo BT, Li C, Tu Y, Khan SA. Novel role of Gia2 in cell migration: Downstream of PI3-kinase-AKT and Rac1 in prostate cancer cells. J Cell Physiol. 2018 01; 234(1):802-815.

View in: PubMed
Scarlett KA, White EZ, Coke CJ, Carter JR, Bryant LK, Hinton CV. Agonist-induced CXCR4 and CB2 Heterodimerization Inhibits Ga13/RhoA-mediated Migration. Mol Cancer Res. 2018 04; 16(4):728-739.

View in: PubMed
Ruiz A, Ruiz L, Col?n-Caraballo M, Torres-Collazo BJ, Monteiro JB, Bayona M, Fazleabas AT, Flores I. Pharmacological blockage of the CXCR4-CXCL12 axis in endometriosis leads to contrasting effects in proliferation, migration, and invasion. Biol Reprod. 2018 01 01; 98(1):4-14.

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Jarrah AA, Schwarskopf M, Wang ER, LaRocca T, Dhume A, Zhang S, Hadri L, Hajjar RJ, Schecter AD, Tarzami ST. SDF-1 induces TNF-mediated apoptosis in cardiac myocytes. Apoptosis. 2018 01; 23(1):79-91.

View in: PubMed
Turvey ME, Klingler-Hoffmann M, Hoffmann P, McColl SR. p84 forms a negative regulatory complex with p110? to control PI3K? signalling during cell migration. Immunol Cell Biol. 2015 Sep; 93(8):735-43.

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Wang ER, Jarrah AA, Benard L, Chen J, Schwarzkopf M, Hadri L, Tarzami ST. Deletion of CXCR4 in cardiomyocytes exacerbates cardiac dysfunction following isoproterenol administration. Gene Ther. 2014 May; 21(5):496-506.

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Xu H, Ye D, Behra M, Burgess S, Chen S, Lin F. G?1 controls collective cell migration by regulating the protrusive activity of leader cells in the posterior lateral line primordium. Dev Biol. 2014 Jan 15; 385(2):316-27.

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Nangami GN, Watson K, Parker-Johnson K, Okereke KO, Sakwe A, Thompson P, Frimpong N, Ochieng J. Fetuin-A (a2HS-glycoprotein) is a serum chemo-attractant that also promotes invasion of tumor cells through Matrigel. Biochem Biophys Res Commun. 2013 Sep 06; 438(4):660-5.

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