Receptors, CXCR4

"Receptors, CXCR4" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus, MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure, which enables searching at various levels of specificity.

MeSH information

Definition | Details | More General Concepts | Related Concepts | More Specific Concepts

CXCR receptors with specificity for CXCL12 CHEMOKINE. The receptors may play a role in HEMATOPOIESIS regulation and can also function as coreceptors for the HUMAN IMMUNODEFICIENCY VIRUS.

Descriptor ID	D019718
MeSH Number(s)	D12.776.543.750.695.160.500.400 D12.776.543.750.705.852.125.500.400 D12.776.543.750.830.700.650
Concept/Terms	Receptors, CXCR4 Receptors, CXCR4 LESTR Receptor CXC Chemokine Receptor 4 Fusin CXCR4 Receptor Receptor, CXCR4 CXCR4 Receptors Leukocyte-Derived Seven-Transmembrane Domain Receptor Leukocyte Derived Seven Transmembrane Domain Receptor Receptor, LESTR

Below are MeSH descriptors whose meaning is more general than "Receptors, CXCR4".

Chemicals and Drugs [D]
Amino Acids, Peptides, and Proteins [D12]
Proteins [D12.776]
Membrane Proteins [D12.776.543]
Receptors, Cell Surface [D12.776.543.750]
Receptors, G-Protein-Coupled [D12.776.543.750.695]
Receptors, Chemokine [D12.776.543.750.695.160]
Receptors, CXCR [D12.776.543.750.695.160.500]
Receptors, CXCR4 [D12.776.543.750.695.160.500.400]
Receptors, Immunologic [D12.776.543.750.705]
Receptors, Cytokine [D12.776.543.750.705.852]
Receptors, Chemokine [D12.776.543.750.705.852.125]
Receptors, CXCR [D12.776.543.750.705.852.125.500]
Receptors, CXCR4 [D12.776.543.750.705.852.125.500.400]
Receptors, Virus [D12.776.543.750.830]
Receptors, HIV [D12.776.543.750.830.700]
Receptors, CXCR4 [D12.776.543.750.830.700.650]

Below are MeSH descriptors whose meaning is related to "Receptors, CXCR4".

Below are MeSH descriptors whose meaning is more specific than "Receptors, CXCR4".

publications

Timeline | Most Recent

This graph shows the total number of publications written about "Receptors, CXCR4" by people in this website by year, and whether "Receptors, CXCR4" was a major or minor topic of these publications.

Bar chart showing 56 publications over 23 distinct years, with a maximum of 5 publications in 2010 and 2018

To see the data from this visualization as text, click here.

Year	Major Topic	Minor Topic	Total
1998	2	1	3
1999	0	1	1
2000	0	2	2
2001	1	0	1
2002	0	1	1
2003	1	1	2
2004	4	0	4
2005	1	0	1
2007	3	1	4
2008	2	2	4
2009	2	1	3
2010	5	0	5
2011	2	2	4
2012	1	2	3
2013	1	2	3
2014	1	1	2
2015	1	0	1
2016	1	0	1
2017	1	0	1
2018	4	1	5
2019	1	2	3
2021	0	1	1
2024	1	0	1

Below are the most recent publications written about "Receptors, CXCR4" by people in Profiles.

Zhou Z, Guo J, Hetrick B, Tiwari S, Haikerwal A, Han Y, Bond VC, Huang MB, Mankowski MK, Snyder BA, Hogan PA, Sharma SK, Liotta DC, Reid TE, Wilson LJ, Wu Y. Characterization of a CXCR4 antagonist TIQ-15 with dual tropic HIV entry inhibition properties. PLoS Pathog. 2024 Aug; 20(8):e1012448.

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Thakur V, Alcoreza N, Delgado M, Joddar B, Chattopadhyay M. Cardioprotective Effect of Glycyrrhizin on Myocardial Remodeling in Diabetic Rats. Biomolecules. 2021 04 13; 11(4).

View in: PubMed
LaRocca TJ, Altman P, Jarrah AA, Gordon R, Wang E, Hadri L, Burke MW, Haddad GE, Hajjar RJ, Tarzami ST. CXCR4 Cardiac Specific Knockout Mice Develop a Progressive Cardiomyopathy. Int J Mol Sci. 2019 May 08; 20(9).

View in: PubMed
Khan S, Setua S, Kumari S, Dan N, Massey A, Hafeez BB, Yallapu MM, Stiles ZE, Alabkaa A, Yue J, Ganju A, Behrman S, Jaggi M, Chauhan SC. Superparamagnetic iron oxide nanoparticles of curcumin enhance gemcitabine therapeutic response in pancreatic cancer. Biomaterials. 2019 07; 208:83-97.

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Gao C, Xiao G, Piersigilli A, Gou J, Ogunwobi O, Bargonetti J. Context-dependent roles of MDMX (MDM4) and MDM2 in breast cancer proliferation and circulating tumor cells. Breast Cancer Res. 2019 01 14; 21(1):5.

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Hsu WT, Lin CH, Jui HY, Tseng YH, Shun CT, Hsu MC, Wu KK, Lee CM. CXCR4 Antagonist Reduced the Incidence of Acute Rejection and Controlled Cardiac Allograft Vasculopathy in a Swine Heart Transplant Model Receiving a Mycophenolate-based Immunosuppressive Regimen. Transplantation. 2018 12; 102(12):2002-2011.

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Hersh TA, Dimond AL, Ruth BA, Lupica NV, Bruce JC, Kelley JM, King BL, Lutton BV. A role for the CXCR4-CXCL12 axis in the little skate, Leucoraja erinacea. Am J Physiol Regul Integr Comp Physiol. 2018 08 01; 315(2):R218-R229.

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Scarlett KA, White EZ, Coke CJ, Carter JR, Bryant LK, Hinton CV. Agonist-induced CXCR4 and CB2 Heterodimerization Inhibits Ga13/RhoA-mediated Migration. Mol Cancer Res. 2018 04; 16(4):728-739.

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Ruiz A, Ruiz L, Col?n-Caraballo M, Torres-Collazo BJ, Monteiro JB, Bayona M, Fazleabas AT, Flores I. Pharmacological blockage of the CXCR4-CXCL12 axis in endometriosis leads to contrasting effects in proliferation, migration, and invasion. Biol Reprod. 2018 01 01; 98(1):4-14.

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Jarrah AA, Schwarskopf M, Wang ER, LaRocca T, Dhume A, Zhang S, Hadri L, Hajjar RJ, Schecter AD, Tarzami ST. SDF-1 induces TNF-mediated apoptosis in cardiac myocytes. Apoptosis. 2018 01; 23(1):79-91.

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