Receptor, Insulin

"Receptor, Insulin" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus, MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure, which enables searching at various levels of specificity.

MeSH information

Definition | Details | More General Concepts | Related Concepts | More Specific Concepts

A cell surface receptor for INSULIN. It comprises a tetramer of two alpha and two beta subunits which are derived from cleavage of a single precursor protein. The receptor contains an intrinsic TYROSINE KINASE domain that is located within the beta subunit. Activation of the receptor by INSULIN results in numerous metabolic changes including increased uptake of GLUCOSE into the liver, muscle, and ADIPOSE TISSUE.

Descriptor ID	D011972
MeSH Number(s)	D08.811.913.696.620.682.725.400.200 D12.776.543.750.630.484 D12.776.543.750.750.580.300
Concept/Terms	Receptor, Insulin Receptor, Insulin Receptors, Insulin Insulin Receptors Insulin Receptor Protein-Tyrosine Kinase Insulin Receptor Protein Tyrosine Kinase Insulin Receptor Insulin-Dependent Tyrosine Protein Kinase Insulin Receptor beta Subunit Insulin Receptor beta Subunit Insulin Receptor beta Chain Insulin Receptor alpha Subunit Insulin Receptor alpha Subunit Insulin Receptor alpha Chain

Below are MeSH descriptors whose meaning is more general than "Receptor, Insulin".

Chemicals and Drugs [D]
Enzymes and Coenzymes [D08]
Enzymes [D08.811]
Transferases [D08.811.913]
Phosphotransferases [D08.811.913.696]
Phosphotransferases (Alcohol Group Acceptor) [D08.811.913.696.620]
Protein Kinases [D08.811.913.696.620.682]
Protein-Tyrosine Kinases [D08.811.913.696.620.682.725]
Receptor Protein-Tyrosine Kinases [D08.811.913.696.620.682.725.400]
Receptor, Insulin [D08.811.913.696.620.682.725.400.200]
Amino Acids, Peptides, and Proteins [D12]
Proteins [D12.776]
Membrane Proteins [D12.776.543]
Receptors, Cell Surface [D12.776.543.750]
Receptor Protein-Tyrosine Kinases [D12.776.543.750.630]
Receptor, Insulin [D12.776.543.750.630.484]
Receptors, Peptide [D12.776.543.750.750]
Receptors, Pancreatic Hormone [D12.776.543.750.750.580]
Receptor, Insulin [D12.776.543.750.750.580.300]

Below are MeSH descriptors whose meaning is related to "Receptor, Insulin".

Below are MeSH descriptors whose meaning is more specific than "Receptor, Insulin".

publications

Timeline | Most Recent

This graph shows the total number of publications written about "Receptor, Insulin" by people in this website by year, and whether "Receptor, Insulin" was a major or minor topic of these publications.

Bar chart showing 19 publications over 14 distinct years, with a maximum of 2 publications in 2001 and 2003 and 2012 and 2018 and 2022

To see the data from this visualization as text, click here.

Year	Major Topic	Minor Topic	Total
1999	0	1	1
2000	1	0	1
2001	1	1	2
2003	0	2	2
2005	1	0	1
2008	1	0	1
2012	1	1	2
2014	0	1	1
2015	1	0	1
2016	0	1	1
2018	0	2	2
2019	1	0	1
2022	0	2	2
2024	0	1	1

Below are the most recent publications written about "Receptor, Insulin" by people in Profiles.

Zhou AL, Swaminathan SK, Salian VS, Wang L, Curran GL, Min HK, Lowe VJ, Kandimalla KK. Insulin Signaling Differentially Regulates the Trafficking of Insulin and Amyloid Beta Peptides at the Blood-Brain Barrier. Mol Pharm. 2024 May 06; 21(5):2176-2186.

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Taubel JC, Nelson NR, Bansal A, Curran GL, Wang L, Wang Z, Berg HM, Vernon CJ, Min HK, Larson NB, DeGrado TR, Kandimalla KK, Lowe VJ, Pandey MK. Design, Synthesis, and Preliminary Evaluation of [68Ga]Ga-NOTA-Insulin as a PET Probe in an Alzheimer's Disease Mouse Model. Bioconjug Chem. 2022 05 18; 33(5):892-906.

View in: PubMed
Abdou HM, Hamaad FA, Ali EY, Ghoneum MH. Antidiabetic efficacy of Trifolium alexandrinum extracts hesperetin and quercetin in ameliorating carbohydrate metabolism and activating IR and AMPK signaling in the pancreatic tissues of diabetic rats. Biomed Pharmacother. 2022 May; 149:112838.

View in: PubMed
Gali CC, Fanaee-Danesh E, Zandl-Lang M, Albrecher NM, Tam-Amersdorfer C, Stracke A, Sachdev V, Reichmann F, Sun Y, Avdili A, Reiter M, Kratky D, Holzer P, Lass A, Kandimalla KK, Panzenboeck U. Amyloid-beta impairs insulin signaling by accelerating autophagy-lysosomal degradation of LRP-1 and IR-? in blood-brain barrier endothelial cells in vitro and in 3XTg-AD mice. Mol Cell Neurosci. 2019 09; 99:103390.

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Kulas JA, Franklin WF, Smith NA, Manocha GD, Puig KL, Nagamoto-Combs K, Hendrix RD, Taglialatela G, Barger SW, Combs CK. Ablation of amyloid precursor protein increases insulin-degrading enzyme levels and activity in brain and peripheral tissues. Am J Physiol Endocrinol Metab. 2019 01 01; 316(1):E106-E120.

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Ochieng J, Nangami G, Sakwe A, Moye C, Alvarez J, Whalen D, Thomas P, Lammers P. Impact of Fetuin-A (AHSG) on Tumor Progression and Type 2 Diabetes. Int J Mol Sci. 2018 Jul 29; 19(8).

View in: PubMed
Merritt MA, Strickler HD, Einstein MH, Yang HP, Sherman ME, Wentzensen N, Brouwer-Visser J, Cossio MJ, Whitney KD, Yu H, Gunter MJ, Huang GS. Insulin/IGF and sex hormone axes in human endometrium and associations with endometrial cancer risk factors. Cancer Causes Control. 2016 06; 27(6):737-48.

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Gerena Y, Men?ndez-Delmestre R, Skolasky RL, Hechavarria RM, P?rez S, Hilera C, Gonz?lez C, Nath A, Wojna V. Soluble insulin receptor as a source of insulin resistance and cognitive impairment in HIV-seropositive women. J Neurovirol. 2015 Apr; 21(2):113-9.

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Zhao B, Kokoza VA, Saha TT, Wang S, Roy S, Raikhel AS. Regulation of the gut-specific carboxypeptidase: a study using the binary Gal4/UAS system in the mosquito Aedes aegypti. Insect Biochem Mol Biol. 2014 Nov; 54:1-10.

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Gerena Y, Skolasky RL, Velez JM, Toro-Nieves D, Mayo R, Nath A, Wojna V. Soluble and cell-associated insulin receptor dysfunction correlates with severity of HAND in HIV-infected women. PLoS One. 2012; 7(5):e37358.

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