Tyrosine 3-Monooxygenase

"Tyrosine 3-Monooxygenase" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus, MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure, which enables searching at various levels of specificity.

MeSH information

Definition | Details | More General Concepts | Related Concepts | More Specific Concepts

An enzyme that catalyzes the conversion of L-tyrosine, tetrahydrobiopterin, and oxygen to 3,4-dihydroxy-L-phenylalanine, dihydrobiopterin, and water. EC 1.14.16.2.

Descriptor ID	D014446
MeSH Number(s)	D08.811.682.690.708.923 D12.776.556.579.374.925
Concept/Terms	Tyrosine 3-Monooxygenase Tyrosine 3-Monooxygenase 3-Monooxygenase, Tyrosine Tyrosine 3 Monooxygenase Tyrosine Hydroxylase Hydroxylase, Tyrosine

Below are MeSH descriptors whose meaning is more general than "Tyrosine 3-Monooxygenase".

Chemicals and Drugs [D]
Enzymes and Coenzymes [D08]
Enzymes [D08.811]
Oxidoreductases [D08.811.682]
Oxygenases [D08.811.682.690]
Mixed Function Oxygenases [D08.811.682.690.708]
Tyrosine 3-Monooxygenase [D08.811.682.690.708.923]
Amino Acids, Peptides, and Proteins [D12]
Proteins [D12.776]
Metalloproteins [D12.776.556]
Iron-Binding Proteins [D12.776.556.579]
Nonheme Iron Proteins [D12.776.556.579.374]
Tyrosine 3-Monooxygenase [D12.776.556.579.374.925]

Below are MeSH descriptors whose meaning is more specific than "Tyrosine 3-Monooxygenase".

publications

Timeline | Most Recent

This graph shows the total number of publications written about "Tyrosine 3-Monooxygenase" by people in this website by year, and whether "Tyrosine 3-Monooxygenase" was a major or minor topic of these publications.

Bar chart showing 60 publications over 23 distinct years, with a maximum of 5 publications in 2003 and 2004

To see the data from this visualization as text, click here.

Year	Major Topic	Minor Topic	Total
1996	2	0	2
2000	1	0	1
2002	0	3	3
2003	2	3	5
2004	2	3	5
2005	0	4	4
2006	0	1	1
2007	1	1	2
2008	0	2	2
2009	0	3	3
2010	1	2	3
2011	1	2	3
2012	0	3	3
2013	0	2	2
2014	1	0	1
2015	2	1	3
2016	0	2	2
2017	0	3	3
2018	1	3	4
2019	0	2	2
2020	2	1	3
2021	0	1	1
2025	0	2	2

Below are the most recent publications written about "Tyrosine 3-Monooxygenase" by people in Profiles.

Kim S, Pajarillo E, Digman A, Ajayi I, Son DS, Aschner M, Lee E. CAD (Cath. a-Differentiated) Cells Produce Dopamine along with Dopamine-Synthesizing Enzymes. Neurochem Res. 2025 Jul 16; 50(4):233.

View in: PubMed
Bono BS, Negishi K, Dumiaty Y, Ponce-Ruiz MS, Akinbode TC, Baker KS, Spencer CDP, Mejia E, Guirguis M, Hebert AJ, Khan AM, Chee MJ. Brainwide Projections of Mouse Dopaminergic Zona Incerta Neurons. J Comp Neurol. 2025 Mar; 533(3):e70039.

View in: PubMed
Rodichkin AN, Edler MK, McGlothan JL, Guilarte TR. Behavioral and neurochemical studies of inherited manganese-induced dystonia-parkinsonism in Slc39a14-knockout mice. Neurobiol Dis. 2021 10; 158:105467.

View in: PubMed
Pajarillo E, Johnson J, Rizor A, Nyarko-Danquah I, Adinew G, Bornhorst J, Stiboller M, Schwerdtle T, Son DS, Aschner M, Lee E. Astrocyte-specific deletion of the transcription factor Yin Yang 1 in murine substantia nigra mitigates manganese-induced dopaminergic neurotoxicity. J Biol Chem. 2020 11 13; 295(46):15662-15676.

View in: PubMed
Pajarillo E, Rizor A, Son DS, Aschner M, Lee E. The transcription factor REST up-regulates tyrosine hydroxylase and antiapoptotic genes and protects dopaminergic neurons against manganese toxicity. J Biol Chem. 2020 03 06; 295(10):3040-3054.

View in: PubMed
Negishi K, Payant MA, Schumacker KS, Wittmann G, Butler RM, Lechan RM, Steinbusch HWM, Khan AM, Chee MJ. Distributions of hypothalamic neuron populations coexpressing tyrosine hydroxylase and the vesicular GABA transporter in the mouse. J Comp Neurol. 2020 07 15; 528(11):1833-1855.

View in: PubMed
Sampath C, Kalpana R, Ansah T, Charlton C, Hale A, Channon KM, Srinivasan S, Gangula PR. Impairment of Nrf2- and Nitrergic-Mediated Gastrointestinal Motility in an MPTP Mouse Model of Parkinson's Disease. Dig Dis Sci. 2019 12; 64(12):3502-3517.

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Klambatsen A, Nygard SK, Chang AJ, Quinones V, Jenab S. Sex differences in memory and intracellular signaling after methamphetamine binge treatment. Brain Res. 2019 05 15; 1711:16-22.

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Brown JW, Schaub BM, Klusas BL, Tran AX, Duman AJ, Haney SJ, Boris AC, Flanagan MP, Delgado N, Torres G, Rol?n-Mart?nez S, Vaasjo LO, Miller MW, Gillette R. A role for dopamine in the peripheral sensory processing of a gastropod mollusc. PLoS One. 2018; 13(12):e0208891.

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Gilbreath ET, Jaganathan L, Subramanian M, Balasubramanian P, Linning KD, MohanKumar SMJ, MohanKumar PS. Chronic estrogen affects TIDA neurons through IL-1? and NO: effects of aging. J Endocrinol. 2019 02 01; 240(2):157-167.

View in: PubMed

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