Cholesterol Side-Chain Cleavage Enzyme
"Cholesterol Side-Chain Cleavage Enzyme" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
A mitochondrial cytochrome P450 enzyme that catalyzes the side-chain cleavage of C27 cholesterol to C21 pregnenolone in the presence of molecular oxygen and NADPH-FERRIHEMOPROTEIN REDUCTASE. This enzyme, encoded by CYP11A1 gene, catalyzes the breakage between C20 and C22 which is the initial and rate-limiting step in the biosynthesis of various gonadal and adrenal steroid hormones.
| Descriptor ID |
D002786
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| MeSH Number(s) |
D08.244.453.484.250 D08.244.453.915.212 D08.811.682.690.708.170.425.250 D08.811.682.690.708.170.915.212 D12.776.422.220.453.484.250 D12.776.422.220.453.915.212
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| Concept/Terms |
Cholesterol Side-Chain Cleavage Enzyme- Cholesterol Side-Chain Cleavage Enzyme
- Cholesterol Side Chain Cleavage Enzyme
- Cholesterol Desmolase
- Cytochrome P-450(scc)
- CYP11A1
- CYP 11A1
- Cytochrome P450 11A1
- Cytochrome P-450 CYP11A1
- Cytochrome P 450 CYP11A1
- Cholesterol Monooxygenase (Side-Chain-Cleaving)
- 20,22-Desmolase
- 20,22 Desmolase
- Cytochrome P450scc
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Below are MeSH descriptors whose meaning is more general than "Cholesterol Side-Chain Cleavage Enzyme".
Below are MeSH descriptors whose meaning is more specific than "Cholesterol Side-Chain Cleavage Enzyme".
This graph shows the total number of publications written about "Cholesterol Side-Chain Cleavage Enzyme" by people in this website by year, and whether "Cholesterol Side-Chain Cleavage Enzyme" was a major or minor topic of these publications.
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| Year | Major Topic | Minor Topic | Total |
|---|
| 2002 | 0 | 1 | 1 |
| 2009 | 0 | 2 | 2 |
| 2010 | 0 | 2 | 2 |
| 2019 | 0 | 1 | 1 |
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Below are the most recent publications written about "Cholesterol Side-Chain Cleavage Enzyme" by people in Profiles.
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Zhu H, Qin N, Xu X, Sun X, Chen X, Zhao J, Xu R, Mishra B. Synergistic inhibition of csal1 and csal3 in granulosa cell proliferation and steroidogenesis of hen ovarian prehierarchical development?. Biol Reprod. 2019 11 21; 101(5):986-1000.
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Chen MC, Wang SW, Kan SF, Tsai SC, Wu YC, Wang PS. Stimulatory effects of propylthiouracil on pregnenolone production through upregulation of steroidogenic acute regulatory protein expression in rat granulosa cells. Toxicol Sci. 2010 Dec; 118(2):667-74.
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Chang LL, Alfred Wun WS, Wang PS. Effects and mechanisms of nonylphenol on corticosterone release in rat zona fasciculata-reticularis cells. Toxicol Sci. 2010 Dec; 118(2):411-9.
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Wu JJ, Wang KL, Wang SW, Hwang GS, Mao IF, Chen ML, Wang PS. Differential effects of nonylphenol on testosterone secretion in rat Leydig cells. Toxicology. 2010 Jan 31; 268(1-2):1-7.
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Yu PL, Chao HL, Wang SW, Wang PS. Effects of evodiamine and rutaecarpine on the secretion of corticosterone by zona fasciculata-reticularis cells in male rats. J Cell Biochem. 2009 Oct 01; 108(2):469-75.
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Chen JJ, Chien EJ, Wang PS. Progesterone attenuates the inhibitory effects of cardiotonic digitalis on pregnenolone production in rat luteal cells. J Cell Biochem. 2002; 86(1):107-17.
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Akinbami MA, Philip GH, Sridaran R, Mahesh VB, Mann DR. Expression of mRNA and proteins for testicular steroidogenic enzymes and brain and pituitary mRNA for glutamate receptors in rats exposed to immobilization stress. J Steroid Biochem Mol Biol. 1999 Sep-Oct; 70(4-6):143-9.
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Chaudhary J, Bhattacharyya S, Das C. Regulation of progesterone secretion in human syncytiotrophoblast in culture by human chorionic gonadotropin. J Steroid Biochem Mol Biol. 1992 May; 42(3-4):425-32.