Leydig Cells

"Leydig Cells" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus, MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure, which enables searching at various levels of specificity.

MeSH information

Definition | Details | More General Concepts | Related Concepts | More Specific Concepts

Steroid-producing cells in the interstitial tissue of the TESTIS. They are under the regulation of PITUITARY HORMONES; LUTEINIZING HORMONE; or interstitial cell-stimulating hormone. TESTOSTERONE is the major androgen (ANDROGENS) produced.

Descriptor ID	D007985
MeSH Number(s)	A05.360.444.849.513 A06.407.312.782.513 A11.382.906 A11.436.513
Concept/Terms	Leydig Cells Leydig Cells Cells, Leydig Testicular Interstitial Cells Interstitial Cells, Testicular Cell, Testicular Interstitial Cells, Testicular Interstitial Interstitial Cell, Testicular Testicular Interstitial Cell

Below are MeSH descriptors whose meaning is more general than "Leydig Cells".

Anatomy [A]
Urogenital System [A05]
Genitalia [A05.360]
Genitalia, Male [A05.360.444]
Testis [A05.360.444.849]
Leydig Cells [A05.360.444.849.513]
Endocrine System [A06]
Endocrine Glands [A06.407]
Gonads [A06.407.312]
Testis [A06.407.312.782]
Leydig Cells [A06.407.312.782.513]
Cells [A11]
Endocrine Cells [A11.382]
Leydig Cells [A11.382.906]
Epithelial Cells [A11.436]
Leydig Cells [A11.436.513]

Below are MeSH descriptors whose meaning is related to "Leydig Cells".

Below are MeSH descriptors whose meaning is more specific than "Leydig Cells".

publications

Timeline | Most Recent

This graph shows the total number of publications written about "Leydig Cells" by people in this website by year, and whether "Leydig Cells" was a major or minor topic of these publications.

Bar chart showing 10 publications over 9 distinct years, with a maximum of 2 publications in 2009

To see the data from this visualization as text, click here.

Year	Major Topic	Minor Topic	Total
2000	0	1	1
2002	0	1	1
2007	1	0	1
2009	2	0	2
2010	1	0	1
2013	0	1	1
2020	0	1	1
2021	0	1	1
2025	1	0	1

Below are the most recent publications written about "Leydig Cells" by people in Profiles.

Lu CC, Chang CH, Chou JC, Yu PL, Wang PS. Regulatory mechanism of ghrelin on testosterone secretion in type 1 diabetic rats. Reprod Fertil. 2025 Jul 01; 6(3).

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Shen YC, Shami AN, Moritz L, Larose H, Manske GL, Ma Q, Zheng X, Sukhwani M, Czerwinski M, Sultan C, Chen H, Gurczynski SJ, Spence JR, Orwig KE, Tallquist M, Li JZ, Hammoud SS. TCF21+ mesenchymal cells contribute to testis somatic cell development, homeostasis, and regeneration in mice. Nat Commun. 2021 06 23; 12(1):3876.

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Lin PH, Kuo TH, Chen CC, Jian CY, Chen CW, Wang KL, Kuo YC, Shen HY, Hsia SM, Wang PS, Lieu FK, Wang SW. Downregulation of testosterone production through luteinizing hormone receptor regulation in male rats exposed to 17a-ethynylestradiol. Sci Rep. 2020 01 31; 10(1):1576.

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Lin CS, Pei KJ, Wang PS, Liu BT. Evidence of higher levels of testosterone during the velvet period in muntjac than in other cervids. Theriogenology. 2014 Feb; 81(3):403-6.

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Yu PL, Pu HF, Chen SY, Wang SW, Wang PS. Effects of catechin, epicatechin and epigallocatechin gallate on testosterone production in rat leydig cells. J Cell Biochem. 2010 May 15; 110(2):333-42.

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Wu JJ, Wang KL, Wang SW, Hwang GS, Mao IF, Chen ML, Wang PS. Differential effects of nonylphenol on testosterone secretion in rat Leydig cells. Toxicology. 2010 Jan 31; 268(1-2):1-7.

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Singh KP, Kumari R, Pevey C, Jackson D, DuMond JW. Long duration exposure to cadmium leads to increased cell survival, decreased DNA repair capacity, and genomic instability in mouse testicular Leydig cells. Cancer Lett. 2009 Jun 28; 279(1):84-92.

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Hwang GS, Wang SW, Tseng WM, Yu CH, Wang PS. Effect of hypoxia on the release of vascular endothelial growth factor and testosterone in mouse TM3 Leydig cells. Am J Physiol Endocrinol Metab. 2007 Jun; 292(6):E1763-9.

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Millena AC, Reddy SC, Bowling GH, Khan SA. Autocrine regulation of steroidogenic function of Leydig cells by transforming growth factor-alpha. Mol Cell Endocrinol. 2004 Sep 30; 224(1-2):29-39.

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Chen JJ, Chien EJ, Wang PS. Progesterone attenuates the inhibitory effects of cardiotonic digitalis on pregnenolone production in rat luteal cells. J Cell Biochem. 2002; 86(1):107-17.

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