"Trophoblasts" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
Cells lining the outside of the BLASTOCYST. After binding to the ENDOMETRIUM, trophoblasts develop into two distinct layers, an inner layer of mononuclear cytotrophoblasts and an outer layer of continuous multinuclear cytoplasm, the syncytiotrophoblasts, which form the early fetal-maternal interface (PLACENTA).
| Descriptor ID |
D014327
|
| MeSH Number(s) |
A11.382.992 A16.254.500.766 A16.710.802
|
| Concept/Terms |
|
Below are MeSH descriptors whose meaning is more general than "Trophoblasts".
Below are MeSH descriptors whose meaning is more specific than "Trophoblasts".
This graph shows the total number of publications written about "Trophoblasts" by people in this website by year, and whether "Trophoblasts" was a major or minor topic of these publications.
To see the data from this visualization as text,
click here.
| Year | Major Topic | Minor Topic | Total |
|---|
| 2002 | 0 | 1 | 1 |
| 2003 | 0 | 1 | 1 |
| 2008 | 1 | 0 | 1 |
| 2009 | 1 | 0 | 1 |
| 2012 | 1 | 0 | 1 |
| 2013 | 1 | 0 | 1 |
| 2014 | 1 | 0 | 1 |
| 2016 | 0 | 5 | 5 |
| 2017 | 3 | 1 | 4 |
| 2020 | 0 | 2 | 2 |
| 2022 | 1 | 0 | 1 |
| 2023 | 0 | 1 | 1 |
| 2024 | 1 | 1 | 2 |
| 2025 | 2 | 1 | 3 |
To return to the timeline,
click here.
Below are the most recent publications written about "Trophoblasts" by people in Profiles.
-
Stein FH, Le NH, Elkin ER. Exposure to the trichloroethylene metabolite S-(1,2-dichlorovinyl)-L-cysteine under hypoxic conditions (%O2 =2?%) alters differential gene expression and mitigates decreased invasion capacity, compared to normoxic conditions (%O2 = 21?%) in HTR-8/SVneo cells. Toxicol Lett. 2025 Dec; 414:111773.
-
Marques AL, Weingrill R, Ospina-Prieto S, Pires K, Cavalcante I, Sousa AK, Cavalcante IC, Oliveira L, Souza S, Fonseca EJ, Garcia J, Lee MJ, Urschitz J, Borbely A. Polystyrene microplastics internalization by term placental chorionic villi explants. Placenta. 2026 Jan; 173:102-110.
-
Nunes LGA, Weingrill RB, Fredrick SBJ, Lorca R, Lee MJ, Atif SM, Chicco AJ, Rosario FJ, Urschitz J. Trophoblast-specific Deptor knockdown enhances trophoblast nutrient transport and fetal growth in mice. Acta Physiol (Oxf). 2025 Apr; 241(4):e70012.
-
Marikawa Y, Alarcon VB. Regulation of trophectoderm morphogenesis by small GTPase RHOA through HIPPO signaling-dependent and -independent mechanisms in mouse preimplantation development. Differentiation. 2025 Jan-Feb; 141:100835.
-
Williams A, Hossack DJ, Thompson N, Sim YE, Wilson C, Schuch V, Hailstorks T, Chakraborty R, Johnson EL. Elevated levels of exogenous prolactin promote inflammation at the maternal-fetal interface via the JAK2/STAT5B signaling axis. Front Immunol. 2024; 15:1496610.
-
Wu B, Gao A, He B, Chen Y, Kong X, Wen F, Gao H. RNA-seq analysis of mitochondria-related genes regulated by AMPK in the human trophoblast cell line BeWo. Animal Model Exp Med. 2025 Apr; 8(4):649-661.
-
Nunes LGA, Rosario FJ, Urschitz J. In vivo placental gene modulation via sonoporation. Placenta. 2025 Jun 13; 166:109-116.
-
Elkin ER, Campbell KA, Lapehn S, Harris SM, Padmanabhan V, Bakulski KM, Paquette AG. Placental single cell transcriptomics: Opportunities for endocrine disrupting chemical toxicology. Mol Cell Endocrinol. 2023 12 01; 578:112066.
-
Wu B, Chen Y, Clarke R, Akala E, Yang P, He B, Gao H. AMPK Signaling Regulates Mitophagy and Mitochondrial ATP Production in Human Trophoblast Cell Line BeWo. Front Biosci (Landmark Ed). 2022 04 01; 27(4):118.
-
Eastman AJ, Vrana EN, Grimaldo MT, Jones AD, Rogers LM, Alcendor DJ, Aronoff DM. Cytotrophoblasts suppress macrophage-mediated inflammation through a contact-dependent mechanism. Am J Reprod Immunol. 2021 03; 85(3):e13352.