"Pregnenolone" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
A 21-carbon steroid, derived from CHOLESTEROL and found in steroid hormone-producing tissues. Pregnenolone is the precursor to GONADAL STEROID HORMONES and the adrenal CORTICOSTEROIDS.
| Descriptor ID |
D011284
|
| MeSH Number(s) |
D04.210.500.745.745.725 D06.472.040.585.745 D06.472.334.851.687.500
|
| Concept/Terms |
Pregnenolone- Pregnenolone
- 5-Pregnen-3-beta-ol-20-one
- 5 Pregnen 3 beta ol 20 one
|
Below are MeSH descriptors whose meaning is more general than "Pregnenolone".
Below are MeSH descriptors whose meaning is more specific than "Pregnenolone".
This graph shows the total number of publications written about "Pregnenolone" by people in this website by year, and whether "Pregnenolone" was a major or minor topic of these publications.
To see the data from this visualization as text,
click here.
| Year | Major Topic | Minor Topic | Total |
|---|
| 2002 | 1 | 0 | 1 |
| 2004 | 1 | 0 | 1 |
| 2006 | 0 | 1 | 1 |
| 2009 | 0 | 1 | 1 |
| 2010 | 1 | 1 | 2 |
| 2012 | 0 | 1 | 1 |
| 2014 | 1 | 0 | 1 |
| 2020 | 1 | 0 | 1 |
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click here.
Below are the most recent publications written about "Pregnenolone" by people in Profiles.
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Salanga MC, Brun NR, Francolini RD, Stegeman JJ, Goldstone JV. CRISPR-Cas9-Mutated Pregnane X Receptor (pxr) Retains Pregnenolone-induced Expression of cyp3a65 in Zebrafish (Danio rerio) Larvae. Toxicol Sci. 2020 03 01; 174(1):51-62.
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Ramos G, Loperena Y, Ortiz G, Reyes F, Szeto A, Vera J, Velez J, Morales J, Morrero D, Castillo L, Dharmawardhane S, Melendez E, Washington AV. The addition of a pregnenolone pendant group enhances the anticancer properties of titanocene dichloride in a mcf-7 xenograft model. Anticancer Res. 2014 Apr; 34(4):1609-15.
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Yu PL, Lin TM, Wang SW, Wang PS. Antisteroidogenic effects of hydrogen peroxide on rat granulosa cells. Free Radic Res. 2012 Jun; 46(6):718-25.
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Chen MC, Wang SW, Kan SF, Tsai SC, Wu YC, Wang PS. Stimulatory effects of propylthiouracil on pregnenolone production through upregulation of steroidogenic acute regulatory protein expression in rat granulosa cells. Toxicol Sci. 2010 Dec; 118(2):667-74.
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Chang LL, Alfred Wun WS, Wang PS. Effects and mechanisms of nonylphenol on corticosterone release in rat zona fasciculata-reticularis cells. Toxicol Sci. 2010 Dec; 118(2):411-9.
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Yu PL, Chao HL, Wang SW, Wang PS. Effects of evodiamine and rutaecarpine on the secretion of corticosterone by zona fasciculata-reticularis cells in male rats. J Cell Biochem. 2009 Oct 01; 108(2):469-75.
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Chang LL, Wun AW, Hung CT, Hsia SM, Chiang W, Wang PS. Effects of crude adlay hull acetone extract on corticosterone release from rat zona fasciculata-reticularis cells. Naunyn Schmiedebergs Arch Pharmacol. 2006 Nov; 374(2):141-52.
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Jorge JC, Gonz?lez L, Fortis A, Cruz ND. Sex-specific modulation of anxiety and locomotion after neonatal exposure to pregnenolone sulfate. Physiol Behav. 2005 Jan 17; 83(5):779-86.
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Chen JJ, Chien EJ, Wang PS. Progesterone attenuates the inhibitory effects of cardiotonic digitalis on pregnenolone production in rat luteal cells. J Cell Biochem. 2002; 86(1):107-17.