"Poloxamer" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
A nonionic polyoxyethylene-polyoxypropylene block co-polymer with the general formula HO(C2H4O)a(-C3H6O)b(C2H4O)aH. It is available in different grades which vary from liquids to solids. It is used as an emulsifying agent, solubilizing agent, surfactant, and wetting agent for antibiotics. Poloxamer is also used in ointment and suppository bases and as a tablet binder or coater. (Martindale The Extra Pharmacopoeia, 31st ed)
| Descriptor ID |
D020442
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| MeSH Number(s) |
D02.033.455.250.700.682 D05.750.741.667 D25.720.741.667 J01.637.051.720.741.667
|
| Concept/Terms |
|
Below are MeSH descriptors whose meaning is more general than "Poloxamer".
Below are MeSH descriptors whose meaning is more specific than "Poloxamer".
This graph shows the total number of publications written about "Poloxamer" by people in this website by year, and whether "Poloxamer" was a major or minor topic of these publications.
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| Year | Major Topic | Minor Topic | Total |
|---|
| 2006 | 0 | 1 | 1 |
| 2010 | 1 | 0 | 1 |
| 2012 | 0 | 1 | 1 |
| 2015 | 0 | 2 | 2 |
| 2018 | 0 | 1 | 1 |
| 2022 | 0 | 1 | 1 |
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Below are the most recent publications written about "Poloxamer" by people in Profiles.
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Chen WN, Shaikh MF, Bhuvanendran S, Date A, Ansari MT, Radhakrishnan AK, Othman I. Poloxamer 188 (P188), A Potential Polymeric Protective Agent for Central Nervous System Disorders: A Systematic Review. Curr Neuropharmacol. 2022; 20(4):799-808.
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Date AA, Halpert G, Babu T, Ortiz J, Kanvinde P, Dimitrion P, Narayan J, Zierden H, Betageri K, Musmanno O, Wiegand H, Huang X, Gumber S, Hanes J, Ensign LM. Mucus-penetrating budesonide nanosuspension enema for local treatment of inflammatory bowel disease. Biomaterials. 2018 12; 185:97-105.
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Mansukhani ND, Guiney LM, Kim PJ, Zhao Y, Alducin D, Ponce A, Larios E, Yacaman MJ, Hersam MC. High-Concentration Aqueous Dispersions of Nanoscale 2D Materials Using Nonionic, Biocompatible Block Copolymers. Small. 2016 Jan 20; 12(3):294-300.
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Graves RA, Ledet GA, Nation CA, Pramar YV, Bostanian LA, Mandal TK. Effect of squalane on mebendazole-loaded Compritol? nanoparticles. J Biomater Sci Polym Ed. 2015; 26(13):868-80.
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Date AA, Shibata A, Goede M, Sanford B, La Bruzzo K, Belshan M, Destache CJ. Development and evaluation of a thermosensitive vaginal gel containing raltegravir+efavirenz loaded nanoparticles for HIV prophylaxis. Antiviral Res. 2012 Dec; 96(3):430-6.
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Rajapaksa TE, Bennett KM, Hamer M, Lytle C, Rodgers VG, Lo DD. Intranasal M cell uptake of nanoparticles is independently influenced by targeting ligands and buffer ionic strength. J Biol Chem. 2010 Jul 30; 285(31):23739-46.
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Padhi BK, Chougule MB, Misra A. Optimization of formulation components and characterization of large respirable powders containing high therapeutic payload. Pharm Dev Technol. 2006; 11(4):465-75.