Poloxamer

"Poloxamer" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus, MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure, which enables searching at various levels of specificity.

MeSH information

Definition | Details | More General Concepts | Related Concepts | More Specific Concepts

A nonionic polyoxyethylene-polyoxypropylene block co-polymer with the general formula HO(C2H4O)a(-C3H6O)b(C2H4O)aH. It is available in different grades which vary from liquids to solids. It is used as an emulsifying agent, solubilizing agent, surfactant, and wetting agent for antibiotics. Poloxamer is also used in ointment and suppository bases and as a tablet binder or coater. (Martindale The Extra Pharmacopoeia, 31st ed)

Descriptor ID	D020442
MeSH Number(s)	D02.033.455.250.700.682 D05.750.741.667 D25.720.741.667 J01.637.051.720.741.667
Concept/Terms	Poloxamer Poloxamer Poloxamer 188 Poloxamer 188 Poloxamer 338 Poloxamer 338 Poloxamer 407 Poloxamer 407 Poloxamers Poloxamers Pluronic F-108 Pluronic F-108 Pluronic F 108 Pluronic F108 Pluronic F-127 Pluronic F-127 Pluronic F 127 Pluronic F127 Pluronic F68 Pluronic F68 Pluronic F-68 Pluronic F 68 Pluronic L-101 Pluronic L-101 Pluronic L 101 Pluronic L101 Pluronic L-121 Pluronic L-121 Pluronic L 121 Pluronic L121 Pluronic L-81 Pluronic L-81 Pluronic L 81 Pluronic L81 Pluronics Pluronics Poloxalkol Poloxalkol Poloxamer 213 Poloxamer 213 Poloxamer 2930 Poloxamer 2930

Below are MeSH descriptors whose meaning is more general than "Poloxamer".

Chemicals and Drugs [D]
Organic Chemicals [D02]
Alcohols [D02.033]
Glycols [D02.033.455]
Ethylene Glycols [D02.033.455.250]
Polyethylene Glycols [D02.033.455.250.700]
Poloxamer [D02.033.455.250.700.682]
Macromolecular Substances [D05]
Polymers [D05.750]
Polyethylene Glycols [D05.750.741]
Poloxamer [D05.750.741.667]
Biomedical and Dental Materials [D25]
Polymers [D25.720]
Polyethylene Glycols [D25.720.741]
Poloxamer [D25.720.741.667]
Technology, Industry, Agriculture [J]
Technology, Industry, and Agriculture [J01]
Manufactured Materials [J01.637]
Biomedical and Dental Materials [J01.637.051]
Polymers [J01.637.051.720]
Polyethylene Glycols [J01.637.051.720.741]
Poloxamer [J01.637.051.720.741.667]

Below are MeSH descriptors whose meaning is related to "Poloxamer".

Below are MeSH descriptors whose meaning is more specific than "Poloxamer".

publications

Timeline | Most Recent

This graph shows the total number of publications written about "Poloxamer" by people in this website by year, and whether "Poloxamer" was a major or minor topic of these publications.

Bar chart showing 10 publications over 9 distinct years, with a maximum of 2 publications in 2015

To see the data from this visualization as text, click here.

Year	Major Topic	Minor Topic	Total
2006	0	1	1
2010	1	0	1
2012	0	1	1
2015	0	2	2
2016	1	0	1
2018	0	1	1
2020	0	1	1
2022	0	1	1
2024	1	0	1

Below are the most recent publications written about "Poloxamer" by people in Profiles.

Wang TJ, Rethi L, Ku MY, Nguyen HT, Chuang AE. A review on revolutionizing ophthalmic therapy: Unveiling the potential of chitosan, hyaluronic acid, cellulose, cyclodextrin, and poloxamer in eye disease treatments. Int J Biol Macromol. 2024 Jul; 273(Pt 2):132700.

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Chen WN, Shaikh MF, Bhuvanendran S, Date A, Ansari MT, Radhakrishnan AK, Othman I. Poloxamer 188 (P188), A Potential Polymeric Protective Agent for Central Nervous System Disorders: A Systematic Review. Curr Neuropharmacol. 2022; 20(4):799-808.

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Gong Y, Chowdhury P, Nagesh PKB, Rahman MA, Zhi K, Yallapu MM, Kumar S. Novel elvitegravir nanoformulation for drug delivery across the blood-brain barrier to achieve HIV-1 suppression in the CNS macrophages. Sci Rep. 2020 03 02; 10(1):3835.

View in: PubMed
Date AA, Halpert G, Babu T, Ortiz J, Kanvinde P, Dimitrion P, Narayan J, Zierden H, Betageri K, Musmanno O, Wiegand AA, Huang X, Gumber S, Hanes J, Ensign LM. Mucus-penetrating budesonide nanosuspension enema for local treatment of inflammatory bowel disease. Biomaterials. 2018 12; 185:97-105.

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Boya VN, Lovett R, Setua S, Gandhi V, Nagesh PKB, Khan S, Jaggi M, Yallapu MM, Chauhan SC. Probing mucin interaction behavior of magnetic nanoparticles. J Colloid Interface Sci. 2017 Feb 15; 488:258-268.

View in: PubMed
Mansukhani ND, Guiney LM, Kim PJ, Zhao Y, Alducin D, Ponce A, Larios E, Yacaman MJ, Hersam MC. High-Concentration Aqueous Dispersions of Nanoscale 2D Materials Using Nonionic, Biocompatible Block Copolymers. Small. 2016 Jan 20; 12(3):294-300.

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Graves RA, Ledet GA, Nation CA, Pramar YV, Bostanian LA, Mandal TK. Effect of squalane on mebendazole-loaded Compritol? nanoparticles. J Biomater Sci Polym Ed. 2015; 26(13):868-80.

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Date AA, Shibata A, Goede M, Sanford B, La Bruzzo K, Belshan M, Destache CJ. Development and evaluation of a thermosensitive vaginal gel containing raltegravir+efavirenz loaded nanoparticles for HIV prophylaxis. Antiviral Res. 2012 Dec; 96(3):430-6.

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Rajapaksa TE, Bennett KM, Hamer M, Lytle C, Rodgers VG, Lo DD. Intranasal M cell uptake of nanoparticles is independently influenced by targeting ligands and buffer ionic strength. J Biol Chem. 2010 Jul 30; 285(31):23739-46.

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Padhi BK, Chougule MB, Misra A. Optimization of formulation components and characterization of large respirable powders containing high therapeutic payload. Pharm Dev Technol. 2006; 11(4):465-75.

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