Steroid 17-alpha-Hydroxylase
"Steroid 17-alpha-Hydroxylase" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
A microsomal cytochrome P450 enzyme that catalyzes the 17-alpha-hydroxylation of progesterone or pregnenolone and subsequent cleavage of the residual two carbons at C17 in the presence of molecular oxygen and NADPH-FERRIHEMOPROTEIN REDUCTASE. This enzyme, encoded by CYP17 gene, generates precursors for glucocorticoid, androgen, and estrogen synthesis. Defects in CYP17 gene cause congenital adrenal hyperplasia (ADRENAL HYPERPLASIA, CONGENITAL) and abnormal sexual differentiation.
| Descriptor ID |
D013254
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| MeSH Number(s) |
D08.244.453.487.500 D08.244.453.915.748 D08.811.682.690.708.170.444.500 D08.811.682.690.708.170.915.748 D12.776.422.220.453.487.500 D12.776.422.220.453.915.748
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| Concept/Terms |
Steroid 17-alpha-Hydroxylase- Steroid 17-alpha-Hydroxylase
- 17-alpha-Hydroxylase, Steroid
- Steroid 17 alpha-Hydroxylase
- 17 alpha-Hydroxylase, Steroid
- Steroid 17 alpha Hydroxylase
- Steroid-17-Hydroxylase
- Steroid 17 Hydroxylase
- Steroid 17-Hydroxylase
- 17-Hydroxylase, Steroid
- Steroid 17-Monooxygenase
- 17-Monooxygenase, Steroid
- Steroid 17 Monooxygenase
- 17,20-Desmolase
- 17,20 Desmolase
- 17,20-Lyase
- 17,20 Lyase
- Cytochrome P450(17 alpha)
- Steroid 17 alpha-Monooxygenase
- 17 alpha-Monooxygenase, Steroid
- Steroid 17 alpha Monooxygenase
- alpha-Monooxygenase, Steroid 17
- CYP17
- 17 alpha-Hydroxylase
- 17 alpha Hydroxylase
- P450(c17)
- Cytochrome P-450(17-alpha)
- 17 alpha-Hydroxylase Cytochrome P-450
- 17 alpha Hydroxylase Cytochrome P 450
- Cytochrome P-450(17 alpha)
17 alpha-Hydroxyprogesterone Aldolase- 17 alpha-Hydroxyprogesterone Aldolase
- 17 alpha Hydroxyprogesterone Aldolase
- Aldolase, 17 alpha-Hydroxyprogesterone
- alpha-Hydroxyprogesterone Aldolase, 17
- Hydroxyprogesterone Aldolase
- Aldolase, Hydroxyprogesterone
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Below are MeSH descriptors whose meaning is more general than "Steroid 17-alpha-Hydroxylase".
Below are MeSH descriptors whose meaning is more specific than "Steroid 17-alpha-Hydroxylase".
This graph shows the total number of publications written about "Steroid 17-alpha-Hydroxylase" by people in this website by year, and whether "Steroid 17-alpha-Hydroxylase" was a major or minor topic of these publications.
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| Year | Major Topic | Minor Topic | Total |
|---|
| 2001 | 1 | 0 | 1 |
| 2010 | 0 | 1 | 1 |
| 2011 | 1 | 0 | 1 |
| 2012 | 1 | 1 | 2 |
| 2014 | 0 | 1 | 1 |
| 2015 | 0 | 1 | 1 |
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Below are the most recent publications written about "Steroid 17-alpha-Hydroxylase" by people in Profiles.
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Schroeder RL, Tram P, Liu J, Foroozesh M, Sridhar J. Novel functionalized 5-(phenoxymethyl)-1,3-dioxane analogs exhibiting cytochrome P450 inhibition: a patent evaluation WO2015048311 (A1). Expert Opin Ther Pat. 2016; 26(1):139-47.
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Sato BL, Ward MA, Astern JM, Kendal-Wright CE, Collier AC. Validation of murine and human placental explant cultures for use in sex steroid and phase II conjugation toxicology studies. Toxicol In Vitro. 2015 Feb; 29(1):103-12.
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Taioli E, Sears V, Watson A, Flores-Obando RE, Jackson MD, Ukoli FA, de Syllos C?lus IM, Fernandez P, McFarlane-Anderson N, Ostrander EA, Rodrigues IS, Stanford JL, Taylor JA, Tulloch-Reid M, Ragin CC. Polymorphisms in CYP17 and CYP3A4 and prostate cancer in men of African descent. Prostate. 2013 May; 73(6):668-76.
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Sugawara A, Sato B, Bal E, Collier AC, Ward MA. Blastomere removal from cleavage-stage mouse embryos alters steroid metabolism during pregnancy. Biol Reprod. 2012 Jul; 87(1):4, 1-9.
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Soifer HS, Souleimanian N, Wu S, Voskresenskiy AM, Collak FK, Cinar B, Stein CA. Direct regulation of androgen receptor activity by potent CYP17 inhibitors in prostate cancer cells. J Biol Chem. 2012 Feb 03; 287(6):3777-87.
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Raunig JM, Yamauchi Y, Ward MA, Collier AC. Assisted reproduction technologies alter steroid delivery to the mouse fetus during pregnancy. J Steroid Biochem Mol Biol. 2011 Aug; 126(1-2):26-34.
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Kittles RA, Panguluri RK, Chen W, Massac A, Ahaghotu C, Jackson A, Ukoli F, Adams-Campbell L, Isaacs W, Dunston GM. Cyp17 promoter variant associated with prostate cancer aggressiveness in African Americans. Cancer Epidemiol Biomarkers Prev. 2001 Sep; 10(9):943-7.
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Mack SO, Garrett WM, Guthrie HD. Absence of correlation between in situ expression of cytochrome P450 17alpha hydroxylase/lyase and 3beta-hydroxysteroid dehydrogenase/(Delta5-4) isomerase messenger ribonucleic acids and steroidogenesis during pubertal development in the rat testis. J Steroid Biochem Mol Biol. 2000 May; 73(1-2):19-28.
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Akinbami MA, Philip GH, Sridaran R, Mahesh VB, Mann DR. Expression of mRNA and proteins for testicular steroidogenic enzymes and brain and pituitary mRNA for glutamate receptors in rats exposed to immobilization stress. J Steroid Biochem Mol Biol. 1999 Sep-Oct; 70(4-6):143-9.
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Akinbami MA, Taylor MF, Collins DC, Mann DR. Effect of a peripheral and a central acting opioid antagonist on the testicular response to stress in rats. Neuroendocrinology. 1994 Apr; 59(4):343-8.