STAT3 Transcription Factor

"STAT3 Transcription Factor" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus, MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure, which enables searching at various levels of specificity.

MeSH information

Definition | Details | More General Concepts | Related Concepts | More Specific Concepts

A signal transducer and activator of transcription that mediates cellular responses to INTERLEUKIN-6 family members. STAT3 is constitutively activated in a variety of TUMORS and is a major downstream transducer for the CYTOKINE RECEPTOR GP130.

Descriptor ID	D050796
MeSH Number(s)	D12.644.360.024.342.300 D12.776.157.057.186.300 D12.776.476.024.430.300 D12.776.930.840.300
Concept/Terms	STAT3 Transcription Factor STAT3 Transcription Factor Transcription Factor, STAT3 LIF-Response Factor LIF Response Factor Acute-Phase Response Factor Acute Phase Response Factor Response Factor, Acute-Phase APRF Transcription Factor Transcription Factor, APRF Signal Transducer and Activator of Transcription 3 IL6-Response Factor IL6 Response Factor STAT3 Protein STAT3b Transcription Factor STAT3b Transcription Factor Transcription Factor, STAT3b Stat3beta Transcription Factor Transcription Factor, Stat3beta STAT3a Transcription Factor STAT3a Transcription Factor Transcription Factor, STAT3a Stat3alpha Transcription Factor Transcription Factor, Stat3alpha

Below are MeSH descriptors whose meaning is more general than "STAT3 Transcription Factor".

Chemicals and Drugs [D]
Amino Acids, Peptides, and Proteins [D12]
Peptides [D12.644]
Intracellular Signaling Peptides and Proteins [D12.644.360]
Adaptor Proteins, Signal Transducing [D12.644.360.024]
STAT Transcription Factors [D12.644.360.024.342]
STAT3 Transcription Factor [D12.644.360.024.342.300]
Proteins [D12.776]
Carrier Proteins [D12.776.157]
Adaptor Proteins, Signal Transducing [D12.776.157.057]
STAT Transcription Factors [D12.776.157.057.186]
STAT3 Transcription Factor [D12.776.157.057.186.300]
Intracellular Signaling Peptides and Proteins [D12.776.476]
Adaptor Proteins, Signal Transducing [D12.776.476.024]
STAT Transcription Factors [D12.776.476.024.430]
STAT3 Transcription Factor [D12.776.476.024.430.300]
Transcription Factors [D12.776.930]
STAT Transcription Factors [D12.776.930.840]
STAT3 Transcription Factor [D12.776.930.840.300]

Below are MeSH descriptors whose meaning is related to "STAT3 Transcription Factor".

Below are MeSH descriptors whose meaning is more specific than "STAT3 Transcription Factor".

publications

Timeline | Most Recent

This graph shows the total number of publications written about "STAT3 Transcription Factor" by people in this website by year, and whether "STAT3 Transcription Factor" was a major or minor topic of these publications.

Bar chart showing 83 publications over 27 distinct years, with a maximum of 8 publications in 2013

To see the data from this visualization as text, click here.

Year	Major Topic	Minor Topic	Total
1996	0	2	2
1997	0	1	1
1998	0	1	1
1999	0	2	2
2002	0	2	2
2003	0	1	1
2006	2	1	3
2007	2	1	3
2008	1	1	2
2009	1	1	2
2010	0	1	1
2011	1	3	4
2012	3	1	4
2013	6	2	8
2014	3	1	4
2015	2	4	6
2016	1	2	3
2017	4	3	7
2018	2	0	2
2019	2	3	5
2020	2	2	4
2021	1	3	4
2022	0	3	3
2023	1	2	3
2024	2	2	4
2025	0	1	1
2026	0	1	1

Below are the most recent publications written about "STAT3 Transcription Factor" by people in Profiles.

da Silva RAG, Tien BYQ, Kao PHN, Antypas H, Celik C, Tan AZC, Ismail MH, Hu G, Chong KKL, Thibault G, Chen J, Kline KA. Enterococcus faecalis-derived lactic acid suppresses macrophage activation to facilitate persistent and polymicrobial wound infections. Cell Host Microbe. 2026 Feb 11; 34(2):245-262.e8.

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Aare M, Lazarte JMS, Muthu M, Rishi AK, Singh M. Genetically bio-engineered PD-L1 targeted exosomes for immunotherapy of resistant triple negative breast cancer. Drug Deliv Transl Res. 2026 Feb; 16(2):693-710.

View in: PubMed
Tsuruta T, Matsumura N, Mizukami K, Goto-Koshino Y, Aoi T, Yamada R, Nagao I, Sakamoto M, Nakagawa T, Fukuoka R, Ohmi A, Chambers JK, Uchida K, Momozawa Y, Tomiyasu H. Investigation of the mutations in the genes involved in Janus kinase/signal transducer and activator of transcription pathway in canine large cell gastrointestinal lymphoma. J Vet Med Sci. 2024 Oct 01; 86(10):1052-1055.

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M?rquez-Garb?n DC, Yanes CD, Llarena G, Elashoff D, Hamilton N, Hardy M, Wadehra M, McCloskey SA, Pietras RJ. Manuka Honey Inhibits Human Breast Cancer Progression in Preclinical Models. Nutrients. 2024 Jul 22; 16(14).

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Ramar V, Guo S, Hudson B, Khedri A, Guo AA, Li J, Liu M. Interaction of NF-?B and FOSL1 drives glioma stemness. Cell Mol Life Sci. 2024 Jun 10; 81(1):255.

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Zhu HT, Luo J, Peng Y, Cheng XF, Wu SZ, Zhao YD, Chang L, Sun ZJ, Dong DL. Nitazoxanide protects against experimental ulcerative colitis through improving intestinal barrier and inhibiting inflammation. Chem Biol Interact. 2024 May 25; 395:111013.

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Chen Y, Zhai N, Zhu Y, Yue P, Verma N, Brotherton-Pleiss C, Fu W, Nakamura K, Chen W, Kawakami J, Murali R, Tius MA, Lopez-Tapia F, Turkson J. Azetidine ring, salicylic acid, and salicylic acid bioisosteres as determinants of the binding characteristics of novel potent compounds to Stat3. Bioorg Med Chem Lett. 2024 01 01; 97:129565.

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Kojima K, Chambers JK, Nakashima K, Uchida K. Pro-inflammatory cytokine expression and the STAT1/3 pathway in canine chronic enteropathy and intestinal T-cell lymphoma. Vet Pathol. 2024 05; 61(3):382-392.

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Guo S, Ramar V, Guo AA, Saafir T, Akpobiyeri H, Hudson B, Li J, Liu M. TRPM7 transactivates the FOSL1 gene through STAT3 and enhances glioma stemness. Cell Mol Life Sci. 2023 Aug 29; 80(9):270.

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Zhu Y, Yue P, Dickinson CF, Yang JK, Datanagan K, Zhai N, Zhang Y, Miklossy G, Lopez-Tapia F, Tius MA, Turkson J. Natural product preferentially targets redox and metabolic adaptations and aberrantly active STAT3 to inhibit breast tumor growth in vivo. Cell Death Dis. 2022 12 06; 13(12):1022.

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