CD4-Positive T-Lymphocytes

"CD4-Positive T-Lymphocytes" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus, MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure, which enables searching at various levels of specificity.

MeSH information

Definition | Details | More General Concepts | Related Concepts | More Specific Concepts

A critical subpopulation of T-lymphocytes involved in the induction of most immunological functions. The HIV virus has selective tropism for the T4 cell which expresses the CD4 phenotypic marker, a receptor for HIV. In fact, the key element in the profound immunosuppression seen in HIV infection is the depletion of this subset of T-lymphocytes.

Descriptor ID	D015496
MeSH Number(s)	A11.118.637.555.567.569.200 A15.145.229.637.555.567.569.200 A15.382.490.555.567.569.200
Concept/Terms	CD4-Positive T-Lymphocytes CD4-Positive T-Lymphocytes CD4 Positive T Lymphocytes CD4-Positive T-Lymphocyte T-Lymphocyte, CD4-Positive T-Lymphocytes, CD4-Positive CD4-Positive Lymphocytes CD4-Positive Lymphocyte Lymphocyte, CD4-Positive Lymphocytes, CD4-Positive T4 Cells T4 Cell T4 Lymphocytes T4 Lymphocyte

Below are MeSH descriptors whose meaning is more general than "CD4-Positive T-Lymphocytes".

Anatomy [A]
Cells [A11]
Blood Cells [A11.118]
Leukocytes [A11.118.637]
Leukocytes, Mononuclear [A11.118.637.555]
Lymphocytes [A11.118.637.555.567]
T-Lymphocytes [A11.118.637.555.567.569]
CD4-Positive T-Lymphocytes [A11.118.637.555.567.569.200]
Hemic and Immune Systems [A15]
Blood [A15.145]
Blood Cells [A15.145.229]
Leukocytes [A15.145.229.637]
Leukocytes, Mononuclear [A15.145.229.637.555]
Lymphocytes [A15.145.229.637.555.567]
T-Lymphocytes [A15.145.229.637.555.567.569]
CD4-Positive T-Lymphocytes [A15.145.229.637.555.567.569.200]
Immune System [A15.382]
Leukocytes [A15.382.490]
Leukocytes, Mononuclear [A15.382.490.555]
Lymphocytes [A15.382.490.555.567]
T-Lymphocytes [A15.382.490.555.567.569]
CD4-Positive T-Lymphocytes [A15.382.490.555.567.569.200]

Below are MeSH descriptors whose meaning is related to "CD4-Positive T-Lymphocytes".

Below are MeSH descriptors whose meaning is more specific than "CD4-Positive T-Lymphocytes".

publications

Timeline | Most Recent

This graph shows the total number of publications written about "CD4-Positive T-Lymphocytes" by people in this website by year, and whether "CD4-Positive T-Lymphocytes" was a major or minor topic of these publications.

Bar chart showing 186 publications over 26 distinct years, with a maximum of 16 publications in 2010

To see the data from this visualization as text, click here.

Year	Major Topic	Minor Topic	Total
1992	0	1	1
1996	0	1	1
1997	0	2	2
1998	3	2	5
1999	0	4	4
2000	2	1	3
2001	2	5	7
2002	3	3	6
2003	2	3	5
2004	6	5	11
2005	1	3	4
2006	5	4	9
2007	2	5	7
2008	6	2	8
2009	3	6	9
2010	9	7	16
2011	6	2	8
2012	6	9	15
2013	5	4	9
2014	7	4	11
2015	6	4	10
2016	7	4	11
2017	5	2	7
2018	3	2	5
2019	7	4	11
2020	1	0	1

Below are the most recent publications written about "CD4-Positive T-Lymphocytes" by people in Profiles.

Aamer HA, McClure J, Ko D, Maenza J, Collier AC, Coombs RW, Mullins JI, Frenkel LM. Cells producing residual viremia during antiretroviral treatment appear to contribute to rebound viremia following interruption of treatment. PLoS Pathog. 2020 08; 16(8):e1008791.

View in: PubMed
Younan P, Santos RI, Ramanathan P, Iampietro M, Nishida A, Dutta M, Ammosova T, Meyer M, Katze MG, Popov VL, Nekhai S, Bukreyev A. Ebola virus-mediated T-lymphocyte depletion is the result of an abortive infection. PLoS Pathog. 2019 10; 15(10):e1008068.

View in: PubMed
Abdulhaqq SA, Martinez M, Kang G, Rodriguez IV, Nichols SM, Beaumont D, Joseph J, Azzoni L, Yin X, Wise M, Weiner D, Liu Q, Foulkes A, Münch J, Kirchhoff F, Coutifaris C, Tomaras GD, Sariol C, Marx PA, Li Q, Kraiselburd EN, Montaner LJ. Repeated semen exposure decreases cervicovaginal SIVmac251 infection in rhesus macaques. Nat Commun. 2019 08 21; 10(1):3753.

View in: PubMed
Gokhale AS, Gangaplara A, Lopez-Occasio M, Thornton AM, Shevach EM. Selective deletion of Eos (Ikzf4) in T-regulatory cells leads to loss of suppressive function and development of systemic autoimmunity. J Autoimmun. 2019 12; 105:102300.

View in: PubMed
Powell MD, Read KA, Sreekumar BK, Oestreich KJ. Ikaros Zinc Finger Transcription Factors: Regulators of Cytokine Signaling Pathways and CD4+ T Helper Cell Differentiation. Front Immunol. 2019; 10:1299.

View in: PubMed
Skadow M, Penna VR, Galant-Swafford J, Shevach EM, Thornton AM. Helios Deficiency Predisposes the Differentiation of CD4+Foxp3- T Cells into Peripherally Derived Regulatory T Cells. J Immunol. 2019 07 15; 203(2):370-378.

View in: PubMed
Lin H, He C, Koprivsek JJ, Chen J, Zhou Z, Arulanandam B, Xu Z, Tang L, Zhong G. Antigen-Specific CD4+ T Cell-Derived Gamma Interferon Is Both Necessary and Sufficient for Clearing Chlamydia from the Small Intestine but Not the Large Intestine. Infect Immun. 2019 06; 87(6).

View in: PubMed
Bowler S, Chew GM, Budoff M, Chow D, Mitchell BI, D'Antoni ML, Siriwardhana C, Ndhlovu LC, Shikuma C. PD-1+ and TIGIT+ CD4 T Cells Are Associated With Coronary Artery Calcium Progression in HIV-Infected Treated Adults. . 2019 05 01; 81(1):e21-e23.

View in: PubMed
Mitchell BI, Laws EI, Ndhlovu LC. Impact of Myeloid Reservoirs in HIV Cure Trials. Curr HIV/AIDS Rep. 2019 04; 16(2):129-140.

View in: PubMed
Colomb F, Giron LB, Premeaux TA, Mitchell BI, Niki T, Papasavvas E, Montaner LJ, Ndhlovu LC, Abdel-Mohsen M. Galectin-9 Mediates HIV Transcription by Inducing TCR-Dependent ERK Signaling. Front Immunol. 2019; 10:267.

View in: PubMed

People

Explore

Similar Concepts

Top Journals