Tumor Necrosis Factor-alpha

"Tumor Necrosis Factor-alpha" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus, MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure, which enables searching at various levels of specificity.

MeSH information

Definition | Details | More General Concepts | Related Concepts | More Specific Concepts

Serum glycoprotein produced by activated MACROPHAGES and other mammalian MONONUCLEAR LEUKOCYTES. It has necrotizing activity against tumor cell lines and increases ability to reject tumor transplants. Also known as TNF-alpha, it is only 30% homologous to TNF-beta (LYMPHOTOXIN), but they share TNF RECEPTORS.

Descriptor ID	D014409
MeSH Number(s)	D12.644.276.374.500.800 D12.644.276.374.750.626 D12.776.124.900 D12.776.395.930 D12.776.467.374.500.800 D12.776.467.374.750.626 D23.529.374.500.800 D23.529.374.750.626
Concept/Terms	Tumor Necrosis Factor-alpha Tumor Necrosis Factor-alpha Tumor Necrosis Factor alpha Cachectin Cachectin-Tumor Necrosis Factor Cachectin Tumor Necrosis Factor Tumor Necrosis Factor Ligand Superfamily Member 2 Tumor Necrosis Factor TNF Superfamily, Member 2 TNFalpha TNF-alpha

Below are MeSH descriptors whose meaning is more general than "Tumor Necrosis Factor-alpha".

Chemicals and Drugs [D]
Amino Acids, Peptides, and Proteins [D12]
Peptides [D12.644]
Intercellular Signaling Peptides and Proteins [D12.644.276]
Cytokines [D12.644.276.374]
Monokines [D12.644.276.374.500]
Tumor Necrosis Factor-alpha [D12.644.276.374.500.800]
Tumor Necrosis Factors [D12.644.276.374.750]
Tumor Necrosis Factor-alpha [D12.644.276.374.750.626]
Proteins [D12.776]
Blood Proteins [D12.776.124]
Tumor Necrosis Factor-alpha [D12.776.124.900]
Glycoproteins [D12.776.395]
Tumor Necrosis Factor-alpha [D12.776.395.930]
Intercellular Signaling Peptides and Proteins [D12.776.467]
Cytokines [D12.776.467.374]
Monokines [D12.776.467.374.500]
Tumor Necrosis Factor-alpha [D12.776.467.374.500.800]
Tumor Necrosis Factors [D12.776.467.374.750]
Tumor Necrosis Factor-alpha [D12.776.467.374.750.626]
Biological Factors [D23]
Intercellular Signaling Peptides and Proteins [D23.529]
Cytokines [D23.529.374]
Monokines [D23.529.374.500]
Tumor Necrosis Factor-alpha [D23.529.374.500.800]
Tumor Necrosis Factors [D23.529.374.750]
Tumor Necrosis Factor-alpha [D23.529.374.750.626]

Below are MeSH descriptors whose meaning is related to "Tumor Necrosis Factor-alpha".

Below are MeSH descriptors whose meaning is more specific than "Tumor Necrosis Factor-alpha".

publications

Timeline | Most Recent

This graph shows the total number of publications written about "Tumor Necrosis Factor-alpha" by people in this website by year, and whether "Tumor Necrosis Factor-alpha" was a major or minor topic of these publications.

Bar chart showing 267 publications over 30 distinct years, with a maximum of 19 publications in 2002 and 2010

To see the data from this visualization as text, click here.

Year	Major Topic	Minor Topic	Total
1996	2	1	3
1997	2	3	5
1998	2	1	3
1999	0	3	3
2001	1	2	3
2002	9	10	19
2003	6	9	15
2004	4	4	8
2005	7	9	16
2006	4	6	10
2007	2	13	15
2008	2	6	8
2009	2	10	12
2010	4	15	19
2011	1	6	7
2012	0	10	10
2013	7	11	18
2014	4	7	11
2015	3	4	7
2016	2	8	10
2017	3	5	8
2018	1	5	6
2019	3	4	7
2020	1	6	7
2021	4	5	9
2022	0	6	6
2023	3	10	13
2024	2	3	5
2025	2	1	3
2026	0	1	1

Below are the most recent publications written about "Tumor Necrosis Factor-alpha" by people in Profiles.

Nishimi K, Linnstaedt SD, Neylan TC, McKibben LA, Albertorio-S?ez LM, Zhao Y, House SL, Beaudoin FL, An X, Stevens JS, Clifford GD, Jovanovic T, Germine LT, Rauch SL, Haran JP, Storrow AB, Musey PI, Hendry PL, Sheikh S, Punches BE, Swor RA, Pascual JL, Seamon MJ, Datner EM, Pearson C, Peak DA, Merchant RC, Domeier RM, Rathlev NK, O'Neil BJ, Sergot P, Sanchez LD, Bruce SE, Harte SE, Kessler RC, Koenen KC, Ressler KJ, McLean SA, O'Donovan A. Inflammatory markers in the emergency department and PTSD symptoms in the AURORA Study: A longitudinal cohort study. Psychol Med. 2026 May 08; 56:e123.

View in: PubMed
Salian VS, Curan GL, Lowe VJ, Tang X, Kalari KR, Kandimalla KK. Elucidating molecular mechanisms governing tumor necrosis factor-alpha-mediated regulation of amyloid beta 42 uptake in blood-brain barrier endothelial cells. Mol Pharmacol. 2026 Jan; 108(1):100088.

View in: PubMed
Cabrera-Fuentes HA, Ruiz-Meana M, Barreto G, Serebruany VL, S?nchez-Vega JT, P?rez-Campos E, Kostin S, B?ning A, Jarqu?n Gonz?lez EE, Al-Suhaimi EA, Rodriguez-Montesinos J, Inserte J, Pedretti S, Yap J, Irei J, Sedding DG, Lecour S, Liehn EA, Garcia-Dorado D, Hausenloy DJ, Boisvert WA, Preissner KT. Extracellular RNA drives TNF-a/TNF-receptor-1 mediated cardiac ischemia/reperfusion injury: Mechanistic insights and therapeutic potential of RNase1. Pharmacol Res. 2025 Nov; 221:107944.

View in: PubMed
Song S, Kim Z, Youn HJ, Cho J, Kim YS, Min JW, Choi SW, Franke AA, Jun S, Joung H, Lee JE. Dietary intake and plasma isoflavones are inversely associated with inflammatory markers in breast cancer survivors: A cross-sectional study. Nutr Res. 2025 Jun; 138:22-32.

View in: PubMed
Choi YJ, Wu X, Lee S, Pyo JS, Cho J, Cao S, Kang KS. Protective effects of methylnissolin and methylnissolin-3-O-?-d-glucopyranoside on TNF-a-induced inflammation in human dermal fibroblasts. Toxicol In Vitro. 2025 Apr; 104:106005.

View in: PubMed
Brai BIC, Joseph RO, Komolafe TR, Amosun BE, Crown OO, Komolafe K, Ogungbe IV. Neem seed oil ameliorates diabetic phenotype by suppressing redox imbalance, dyslipidaemia and pro-inflammatory mediators in a rodent model of type 2 diabetes. Arch Physiol Biochem. 2025 Jun; 131(3):351-365.

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Banerjee S, Oguljahan B, Thompson WE, Chowdhury I. Neuregulin 1 Signaling Attenuates Tumor Necrosis Factor a-Induced Female Rat Luteal Cell Death. Endocrinology. 2024 Sep 26; 165(11).

View in: PubMed
Nyarko-Danquah I, Pajarillo E, Kim S, Digman A, Multani HK, Ajayi I, Son DS, Aschner M, Lee E. Microglial Sp1 induced LRRK2 upregulation in response to manganese exposure, and 17?-estradiol afforded protection against this manganese toxicity. Neurotoxicology. 2024 Jul; 103:105-114.

View in: PubMed
Ouhara K, Takemura T, Taniguchi Y, Fujimori R, Tamura T, Akane Y, Matsuda S, Hamamoto Y, Shintani T, Kajiya M, Munenaga S, Iwata T, Fujita T, Mizuno N. Leucine-rich alpha-2-glycoprotein 1 affects bone destruction via IL-6 in mouse periodontitis model. Oral Dis. 2024 11; 30(8):5294-5304.

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Khan M, Hearn K, Parry C, Rashid M, Brim H, Ashktorab H, Kwabi-Addo B. Mechanism of Antitumor Effects of Saffron in Human Prostate Cancer Cells. Nutrients. 2023 12 28; 16(1).

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