Thioredoxins

"Thioredoxins" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus, MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure, which enables searching at various levels of specificity.

MeSH information

Definition | Details | More General Concepts | Related Concepts | More Specific Concepts

Hydrogen-donating proteins that participates in a variety of biochemical reactions including ribonucleotide reduction and reduction of PEROXIREDOXINS. Thioredoxin is oxidized from a dithiol to a disulfide when acting as a reducing cofactor. The disulfide form is then reduced by NADPH in a reaction catalyzed by THIOREDOXIN REDUCTASE.

Descriptor ID	D013879
MeSH Number(s)	D12.776.915
Concept/Terms	Thioredoxins Thioredoxins Thioredoxin Thioredoxin 2 Thioredoxin 2 Thioredoxin-2 Thioredoxin 1 Thioredoxin 1 Thioredoxin-1

Below are MeSH descriptors whose meaning is more general than "Thioredoxins".

Chemicals and Drugs [D]
Amino Acids, Peptides, and Proteins [D12]
Proteins [D12.776]
Thioredoxins [D12.776.915]

Below are MeSH descriptors whose meaning is related to "Thioredoxins".

Below are MeSH descriptors whose meaning is more specific than "Thioredoxins".

publications

Timeline | Most Recent

This graph shows the total number of publications written about "Thioredoxins" by people in this website by year, and whether "Thioredoxins" was a major or minor topic of these publications.

Bar chart showing 20 publications over 13 distinct years, with a maximum of 3 publications in 2004 and 2021

To see the data from this visualization as text, click here.

Year	Major Topic	Minor Topic	Total
2004	2	1	3
2005	1	0	1
2006	1	1	2
2007	1	0	1
2008	1	0	1
2009	1	0	1
2010	0	1	1
2016	0	1	1
2017	1	0	1
2018	2	0	2
2019	2	0	2
2021	3	0	3
2025	1	0	1

Below are the most recent publications written about "Thioredoxins" by people in Profiles.

Nakayama Y, Kitaura A, Abdali SA, Nguyen TD, Yoshioka J. Mutations in the Txnip PPXY motifs protect against myocardial infarction despite enhanced protein stability. Am J Physiol Heart Circ Physiol. 2026 Jun 01; 330(6):H1732-H1748.

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Aki J, Papp SB, Polk B, Jeffreys S, Tompkins MP, Kalalah AA, Eppinger M, Zhang G, Guentzel MN, Chambers JP, Arulanandam BP, Yu JJ. Characterization of Pilin A and Thioredoxin A Mutant Strains of Acinetobacter baumannii, From a Transposon Insertion Library, for Pili Production and Virulence-Associated Properties. Microbiologyopen. 2025 Dec; 14(6):e70183.

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Li XT, Shen J, Bickel D, Mu DS, Rosen BP, Messens J, Zhang J, Zhao FJ. The Thioredoxin System Powers ArsM-Mediated Arsenite Methylation in Hymenobacter edaphi. Environ Sci Technol. 2025 Aug 19; 59(32):17011-17021.

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Shrihari S, May HC, Yu JJ, Papp SB, Chambers JP, Guentzel MN, Arulanandam BP. Thioredoxin-mediated alteration of protein content and cytotoxicity of Acinetobacter baumannii outer membrane vesicles. Exp Biol Med (Maywood). 2022 02; 247(3):282-288.

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Mukai N, Nakayama Y, Abdali SA, Yoshioka J. Cardiomyocyte-specific Txnip C247S mutation improves left ventricular functional reserve in streptozotocin-induced diabetic mice. Am J Physiol Heart Circ Physiol. 2021 08 01; 321(2):H259-H274.

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Nakayama Y, Mukai N, Wang BF, Yang K, Patwari P, Kitsis RN, Yoshioka J. Txnip C247S mutation protects the heart against acute myocardial infarction. J Mol Cell Cardiol. 2021 06; 155:36-49.

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May HC, Yu JJ, Zhang H, Wang Y, Cap AP, Chambers JP, Guentzel MN, Arulanandam BP. Thioredoxin-A is a virulence factor and mediator of the type IV pilus system in Acinetobacter baumannii. PLoS One. 2019; 14(7):e0218505.

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Gong T, Hashimoto AC, Sasuclark AR, Khadka VS, Gurary A, Pitts MW. Selenoprotein M Promotes Hypothalamic Leptin Signaling and Thioredoxin Antioxidant Activity. Antioxid Redox Signal. 2021 10 01; 35(10):775-787.

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Ketter PM, Yu JJ, Guentzel MN, May HC, Gupta R, Eppinger M, Klose KE, Seshu J, Chambers JP, Cap AP, Arulanandam BP. Acinetobacter baumannii Gastrointestinal Colonization Is Facilitated by Secretory IgA Which Is Reductively Dissociated by Bacterial Thioredoxin A. mBio. 2018 07 10; 9(4).

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Wen Y, Liu YR, Tang TT, Pan MM, Xu SC, Ma KL, Lv LL, Liu H, Liu BC. mROS-TXNIP axis activates NLRP3 inflammasome to mediate renal injury during ischemic AKI. Int J Biochem Cell Biol. 2018 05; 98:43-53.

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