"Proinsulin" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
A pancreatic polypeptide of about 110 amino acids, depending on the species, that is the precursor of insulin. Proinsulin, produced by the PANCREATIC BETA CELLS, is comprised sequentially of the N-terminal B-chain, the proteolytically removable connecting C-peptide, and the C-terminal A-chain. It also contains three disulfide bonds, two between A-chain and B-chain. After cleavage at two locations, insulin and C-peptide are the secreted products. Intact proinsulin with low bioactivity also is secreted in small amounts.
| Descriptor ID |
D011384
|
| MeSH Number(s) |
D06.472.699.587.200.500 D12.644.548.586.200.500 D12.776.811.706
|
| Concept/Terms |
|
Below are MeSH descriptors whose meaning is more general than "Proinsulin".
Below are MeSH descriptors whose meaning is more specific than "Proinsulin".
This graph shows the total number of publications written about "Proinsulin" by people in this website by year, and whether "Proinsulin" was a major or minor topic of these publications.
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| Year | Major Topic | Minor Topic | Total |
|---|
| 1996 | 0 | 1 | 1 |
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Below are the most recent publications written about "Proinsulin" by people in Profiles.
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Zhu X, Rouille Y, Lamango NS, Steiner DF, Lindberg I. Internal cleavage of the inhibitory 7B2 carboxyl-terminal peptide by PC2: a potential mechanism for its inactivation. Proc Natl Acad Sci U S A. 1996 May 14; 93(10):4919-24.