"Focal Adhesions" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
An anchoring junction of the cell to a non-cellular substrate. It is composed of a specialized area of the plasma membrane where bundles of the ACTIN CYTOSKELETON terminate and attach to the transmembrane linkers, INTEGRINS, which in turn attach through their extracellular domains to EXTRACELLULAR MATRIX PROTEINS.
| Descriptor ID |
D022001
|
| MeSH Number(s) |
A11.284.149.165.165.285
|
| Concept/Terms |
Focal Adhesions- Focal Adhesions
- Adhesion, Focal
- Adhesions, Focal
- Focal Adhesion
- Focal Contacts
- Contact, Focal
- Contacts, Focal
- Focal Contact
- Adhesion Plaques
- Adhesion Plaque
- Plaque, Adhesion
- Plaques, Adhesion
- Cell-Matrix Adherens Junctions
- Adherens Junction, Cell-Matrix
- Adherens Junctions, Cell-Matrix
- Cell Matrix Adherens Junctions
- Cell-Matrix Adherens Junction
- Junction, Cell-Matrix Adherens
- Junctions, Cell-Matrix Adherens
|
Below are MeSH descriptors whose meaning is more general than "Focal Adhesions".
Below are MeSH descriptors whose meaning is more specific than "Focal Adhesions".
This graph shows the total number of publications written about "Focal Adhesions" by people in this website by year, and whether "Focal Adhesions" was a major or minor topic of these publications.
To see the data from this visualization as text,
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| Year | Major Topic | Minor Topic | Total |
|---|
| 2004 | 0 | 1 | 1 |
| 2005 | 1 | 0 | 1 |
| 2006 | 1 | 3 | 4 |
| 2010 | 1 | 0 | 1 |
| 2013 | 1 | 0 | 1 |
| 2014 | 1 | 1 | 2 |
| 2015 | 0 | 2 | 2 |
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Below are the most recent publications written about "Focal Adhesions" by people in Profiles.
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Li X, He L, Yue Q, Lu J, Kang N, Xu X, Wang H, Zhang H. MiR-9-5p promotes MSC migration by activating ?-catenin signaling pathway. Am J Physiol Cell Physiol. 2017 Jul 01; 313(1):C80-C93.
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Hadzic E, Catillon M, Halavatyi A, Medves S, Van Troys M, Moes M, Baird MA, Davidson MW, Schaffner-Reckinger E, Ampe C, Friederich E. Delineating the Tes Interaction Site in Zyxin and Studying Cellular Effects of Its Disruption. PLoS One. 2015; 10(10):e0140511.
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Mitra A, Luo J, He Y, Gu Y, Zhang H, Zhao K, Cui K, Song J. Histone modifications induced by MDV infection at early cytolytic and latency phases. BMC Genomics. 2015 Apr 18; 16:311.
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Dabagh M, Jalali P, Butler PJ, Tarbell JM. Shear-induced force transmission in a multicomponent, multicell model of the endothelium. J R Soc Interface. 2014 Sep 06; 11(98):20140431.
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Nangami G, Koumangoye R, Shawn Goodwin J, Sakwe AM, Marshall D, Higginbotham J, Ochieng J. Fetuin-A associates with histones intracellularly and shuttles them to exosomes to promote focal adhesion assembly resulting in rapid adhesion and spreading in breast carcinoma cells. Exp Cell Res. 2014 Nov 01; 328(2):388-400.
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Stricker J, Beckham Y, Davidson MW, Gardel ML. Myosin II-mediated focal adhesion maturation is tension insensitive. PLoS One. 2013; 8(7):e70652.
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Sakwe AM, Koumangoye R, Guillory B, Ochieng J. Annexin A6 contributes to the invasiveness of breast carcinoma cells by influencing the organization and localization of functional focal adhesions. Exp Cell Res. 2011 Apr 01; 317(6):823-37.
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Baptiste TA, James A, Saria M, Ochieng J. Mechano-transduction mediated secretion and uptake of galectin-3 in breast carcinoma cells: implications in the extracellular functions of the lectin. Exp Cell Res. 2007 Feb 15; 313(4):652-64.
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Betzig E, Patterson GH, Sougrat R, Lindwasser OW, Olenych S, Bonifacino JS, Davidson MW, Lippincott-Schwartz J, Hess HF. Imaging intracellular fluorescent proteins at nanometer resolution. Science. 2006 Sep 15; 313(5793):1642-5.
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Yin S, Lockett J, Meng Y, Biliran H, Blouse GE, Li X, Reddy N, Zhao Z, Lin X, Anagli J, Cher ML, Sheng S. Maspin retards cell detachment via a novel interaction with the urokinase-type plasminogen activator/urokinase-type plasminogen activator receptor system. Cancer Res. 2006 Apr 15; 66(8):4173-81.