Mitogen-Activated Protein Kinase 8
"Mitogen-Activated Protein Kinase 8" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
A c-jun amino-terminal kinase that is activated by environmental stress and pro-inflammatory cytokines. Several isoforms of the protein with molecular sizes of 43 and 48 KD exist due to multiple ALTERNATIVE SPLICING.
| Descriptor ID |
D048055
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| MeSH Number(s) |
D08.811.913.696.620.682.700.567.374.500 D12.644.360.450.340.500 D12.776.476.450.340.500
|
| Concept/Terms |
Mitogen-Activated Protein Kinase 8- Mitogen-Activated Protein Kinase 8
- Mitogen Activated Protein Kinase 8
- c-jun Kinase-1
- c jun Kinase 1
- SAP Kinase-1
- SAP Kinase 1
- Stress-Activated Protein Kinase gamma
- Stress Activated Protein Kinase gamma
- c-jun N-Terminal Kinase 1
- c jun N Terminal Kinase 1
- MAPK8 Mitogen-Activated Protein Kinase
- MAPK8 Mitogen Activated Protein Kinase
- JNK1 Kinase
- SAPK1 Mitogen-Activated Protein Kinase
- SAPK1 Mitogen Activated Protein Kinase
- Stress-Activated Protein Kinase 1
- Stress Activated Protein Kinase 1
- Stress-Activated Protein Kinase JNK1
- Stress Activated Protein Kinase JNK1
|
Below are MeSH descriptors whose meaning is more general than "Mitogen-Activated Protein Kinase 8".
Below are MeSH descriptors whose meaning is more specific than "Mitogen-Activated Protein Kinase 8".
This graph shows the total number of publications written about "Mitogen-Activated Protein Kinase 8" by people in this website by year, and whether "Mitogen-Activated Protein Kinase 8" was a major or minor topic of these publications.
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| Year | Major Topic | Minor Topic | Total |
|---|
| 2001 | 0 | 1 | 1 |
| 2003 | 0 | 1 | 1 |
| 2006 | 0 | 1 | 1 |
| 2008 | 0 | 1 | 1 |
| 2009 | 1 | 0 | 1 |
| 2010 | 1 | 0 | 1 |
| 2014 | 2 | 0 | 2 |
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Below are the most recent publications written about "Mitogen-Activated Protein Kinase 8" by people in Profiles.
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Echevarr?a-Vargas IM, Valiyeva F, Vivas-Mej?a PE. Upregulation of miR-21 in cisplatin resistant ovarian cancer via JNK-1/c-Jun pathway. PLoS One. 2014; 9(5):e97094.
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Zhang X, Zhang W, Ma SF, Desai AA, Saraf S, Miasniakova G, Sergueeva A, Ammosova T, Xu M, Nekhai S, Abbasi T, Casanova NG, Steinberg MH, Baldwin CT, Sebastiani P, Prchal JT, Kittles R, Garcia JG, Machado RF, Gordeuk VR. Hypoxic response contributes to altered gene expression and precapillary pulmonary hypertension in patients with sickle cell disease. Circulation. 2014 Apr 22; 129(16):1650-8.
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Sherrin T, Blank T, Hippel C, Rayner M, Davis RJ, Todorovic C. Hippocampal c-Jun-N-terminal kinases serve as negative regulators of associative learning. J Neurosci. 2010 Oct 06; 30(40):13348-61.
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Vivas-Mejia P, Benito JM, Fernandez A, Han HD, Mangala L, Rodriguez-Aguayo C, Chavez-Reyes A, Lin YG, Carey MS, Nick AM, Stone RL, Kim HS, Claret FX, Bornmann W, Hennessy BT, Sanguino A, Peng Z, Sood AK, Lopez-Berestein G. c-Jun-NH2-kinase-1 inhibition leads to antitumor activity in ovarian cancer. Clin Cancer Res. 2010 Jan 01; 16(1):184-94.
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Jia Y, Castellanos J, Wang C, Sinha-Hikim I, Lue Y, Swerdloff RS, Sinha-Hikim AP. Mitogen-activated protein kinase signaling in male germ cell apoptosis in the rat. Biol Reprod. 2009 Apr; 80(4):771-80.
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Sarkar S, Wise KC, Manna SK, Ramesh V, Yamauchi K, Thomas RL, Wilson BL, Kulkarni AD, Pellis NR, Ramesh GT. Activation of activator protein-1 in mouse brain regions exposed to simulated microgravity. In Vitro Cell Dev Biol Anim. 2006 Mar-Apr; 42(3-4):96-9.
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Zhu X, Perry G, Smith MA. Amyotrophic lateral sclerosis: a novel hypothesis involving a gained 'loss of function' in the JNK/SAPK pathway. Redox Rep. 2003; 8(3):129-33.
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Zhu X, Raina AK, Rottkamp CA, Aliev G, Perry G, Boux H, Smith MA. Activation and redistribution of c-jun N-terminal kinase/stress activated protein kinase in degenerating neurons in Alzheimer's disease. J Neurochem. 2001 Jan; 76(2):435-41.