"RNA Interference" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
A gene silencing phenomenon whereby specific dsRNAs (RNA, DOUBLE-STRANDED) trigger the degradation of homologous mRNA (RNA, MESSENGER). The specific dsRNAs are processed into SMALL INTERFERING RNA (siRNA) which serves as a guide for cleavage of the homologous mRNA in the RNA-INDUCED SILENCING COMPLEX. DNA METHYLATION may also be triggered during this process.
| Descriptor ID |
D034622
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| MeSH Number(s) |
G05.308.203.374.790
|
| Concept/Terms |
RNA Interference- RNA Interference
- Interference, RNA
- Gene Silencing, Post-Transcriptional
- Gene Silencing, Post Transcriptional
- RNA Silencing
- Post-Transcriptional Gene Silencing
- Post Transcriptional Gene Silencing
- Post-Transcriptional Gene Silencings
- Silencing, Post-Transcriptional Gene
- RNAi
- Posttranscriptional Gene Silencing
- Gene Silencing, Posttranscriptional
- Gene Silencings, Posttranscriptional
|
Below are MeSH descriptors whose meaning is more general than "RNA Interference".
Below are MeSH descriptors whose meaning is more specific than "RNA Interference".
This graph shows the total number of publications written about "RNA Interference" by people in this website by year, and whether "RNA Interference" was a major or minor topic of these publications.
To see the data from this visualization as text,
click here.
| Year | Major Topic | Minor Topic | Total |
|---|
| 2002 | 0 | 1 | 1 |
| 2003 | 0 | 5 | 5 |
| 2004 | 2 | 3 | 5 |
| 2005 | 1 | 6 | 7 |
| 2006 | 4 | 8 | 12 |
| 2007 | 1 | 10 | 11 |
| 2008 | 3 | 5 | 8 |
| 2009 | 4 | 7 | 11 |
| 2010 | 3 | 16 | 19 |
| 2011 | 3 | 13 | 16 |
| 2012 | 0 | 21 | 21 |
| 2013 | 0 | 10 | 10 |
| 2014 | 2 | 12 | 14 |
| 2015 | 0 | 17 | 17 |
| 2016 | 0 | 11 | 11 |
| 2017 | 2 | 8 | 10 |
| 2018 | 2 | 4 | 6 |
| 2019 | 0 | 8 | 8 |
| 2020 | 0 | 2 | 2 |
| 2021 | 0 | 4 | 4 |
| 2022 | 0 | 1 | 1 |
| 2023 | 0 | 2 | 2 |
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Below are the most recent publications written about "RNA Interference" by people in Profiles.
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Sun CR, Xu D, Yang F, Hou Z, Luo Y, Zhang CY, Shan G, Huang G, Yao X, Chen Y, Li Q, Zhou CZ. Human SIDT1 mediates dsRNA uptake via its phospholipase activity. Cell Res. 2024 01; 34(1):84-87.
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Afrin H, Geetha Bai R, Kumar R, Ahmad SS, Agarwal SK, Nurunnabi M. Oral delivery of RNAi for cancer therapy. Cancer Metastasis Rev. 2023 09; 42(3):699-724.
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Dong X, Zheng W. Cheminformatics Modeling of Gene Silencing for Both Natural and Chemically Modified siRNAs. Molecules. 2022 Sep 28; 27(19).
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Dastmalchi K, Chira O, Rodriguez MP, Yoo B, Serra O, Figueras M, Stark RE. A chemical window into the impact of RNAi silencing of the StNAC103 gene in potato tuber periderms: Soluble metabolites, suberized cell walls, and antibacterial defense. Phytochemistry. 2021 Oct; 190:112885.
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Turkistani S, Sugita BM, Fadda P, Marchi R, Afsari A, Naab T, Apprey V, Copeland RL, Campbell MC, Cavalli LR, Kanaan Y. A panel of miRNAs as prognostic markers for African-American patients with triple negative breast cancer. BMC Cancer. 2021 Jul 27; 21(1):861.
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Tang TT, Wang B, Li ZL, Wen Y, Feng ST, Wu M, Liu D, Cao JY, Yin Q, Yin D, Fu YQ, Gao YM, Ding ZY, Qian JY, Wu QL, Lv LL, Liu BC. Kim-1 Targeted Extracellular Vesicles: A New Therapeutic Platform for RNAi to Treat AKI. J Am Soc Nephrol. 2021 10; 32(10):2467-2483.
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Renrick AN, Thounaojam MC, de Aquino MTP, Chaudhuri E, Pandhare J, Dash C, Shanker A. Bortezomib Sustains T Cell Function by Inducing miR-155-Mediated Downregulation of SOCS1 and SHIP1. Front Immunol. 2021; 12:607044.
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Zuo X, Wang L, Bao Y, Sun J. The ESX-1 Virulence Factors Downregulate miR-147-3p in Mycobacterium marinum-Infected Macrophages. Infect Immun. 2020 05 20; 88(6).
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Cinar B, Al-Mathkour MM, Khan SA, Moreno CS. Androgen attenuates the inactivating phospho-Ser-127 modification of yes-associated protein 1 (YAP1) and promotes YAP1 nuclear abundance and activity. J Biol Chem. 2020 06 19; 295(25):8550-8559.
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Jang S, Javadov S. OPA1 regulates respiratory supercomplexes assembly: The role of mitochondrial swelling. Mitochondrion. 2020 03; 51:30-39.