RNA Interference

"RNA Interference" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus, MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure, which enables searching at various levels of specificity.

MeSH information

Definition | Details | More General Concepts | Related Concepts | More Specific Concepts

A gene silencing phenomenon whereby specific dsRNAs (RNA, DOUBLE-STRANDED) trigger the degradation of homologous mRNA (RNA, MESSENGER). The specific dsRNAs are processed into SMALL INTERFERING RNA (siRNA) which serves as a guide for cleavage of the homologous mRNA in the RNA-INDUCED SILENCING COMPLEX. DNA METHYLATION may also be triggered during this process.

Descriptor ID	D034622
MeSH Number(s)	G05.308.203.374.790
Concept/Terms	RNA Interference RNA Interference Interference, RNA Gene Silencing, Post-Transcriptional Gene Silencing, Post Transcriptional RNA Silencing Post-Transcriptional Gene Silencing Post Transcriptional Gene Silencing Post-Transcriptional Gene Silencings Silencing, Post-Transcriptional Gene RNAi Posttranscriptional Gene Silencing Gene Silencing, Posttranscriptional Gene Silencings, Posttranscriptional Cosuppression Cosuppression Co-Suppression Co Suppression

Below are MeSH descriptors whose meaning is more general than "RNA Interference".

Biological Sciences [G]
Genetic Phenomena [G05]
Gene Expression Regulation [G05.308]
Epigenesis, Genetic [G05.308.203]
Gene Silencing [G05.308.203.374]
RNA Interference [G05.308.203.374.790]

Below are MeSH descriptors whose meaning is related to "RNA Interference".

Below are MeSH descriptors whose meaning is more specific than "RNA Interference".

publications

Timeline | Most Recent

This graph shows the total number of publications written about "RNA Interference" by people in this website by year, and whether "RNA Interference" was a major or minor topic of these publications.

Bar chart showing 205 publications over 23 distinct years, with a maximum of 22 publications in 2010

To see the data from this visualization as text, click here.

Year	Major Topic	Minor Topic	Total
2002	0	1	1
2003	0	5	5
2004	2	3	5
2005	1	6	7
2006	4	8	12
2007	1	9	10
2008	3	5	8
2009	4	6	10
2010	3	19	22
2011	3	14	17
2012	0	17	17
2013	1	10	11
2014	2	12	14
2015	0	19	19
2016	0	11	11
2017	2	7	9
2018	2	5	7
2019	0	8	8
2020	1	4	5
2021	0	4	4
2022	0	1	1
2023	0	1	1
2025	1	0	1

Below are the most recent publications written about "RNA Interference" by people in Profiles.

Armstrong R, Romprey MJ, Raughley HM, Delzell SB, Frost MP, Chambers J, Garman GG, Anaguano D, Klingbeil MM. An independently tunable dual control system for RNAi complementation in Trypanosoma brucei. PLoS One. 2025; 20(5):e0321334.

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Afrin H, Geetha Bai R, Kumar R, Ahmad SS, Agarwal SK, Nurunnabi M. Oral delivery of RNAi for cancer therapy. Cancer Metastasis Rev. 2023 09; 42(3):699-724.

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Dong X, Zheng W. Cheminformatics Modeling of Gene Silencing for Both Natural and Chemically Modified siRNAs. Molecules. 2022 Sep 28; 27(19).

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Dastmalchi K, Chira O, Rodriguez MP, Yoo B, Serra O, Figueras M, Stark RE. A chemical window into the impact of RNAi silencing of the StNAC103 gene in potato tuber periderms: Soluble metabolites, suberized cell walls, and antibacterial defense. Phytochemistry. 2021 Oct; 190:112885.

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Turkistani S, Sugita BM, Fadda P, Marchi R, Afsari A, Naab T, Apprey V, Copeland RL, Campbell MC, Cavalli LR, Kanaan Y. A panel of miRNAs as prognostic markers for African-American patients with triple negative breast cancer. BMC Cancer. 2021 Jul 27; 21(1):861.

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Tang TT, Wang B, Li ZL, Wen Y, Feng ST, Wu M, Liu D, Cao JY, Yin Q, Yin D, Fu YQ, Gao YM, Ding ZY, Qian JY, Wu QL, Lv LL, Liu BC. Kim-1 Targeted Extracellular Vesicles: A New Therapeutic Platform for RNAi to Treat AKI. J Am Soc Nephrol. 2021 10; 32(10):2467-2483.

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Renrick AN, Thounaojam MC, de Aquino MTP, Chaudhuri E, Pandhare J, Dash C, Shanker A. Bortezomib Sustains T Cell Function by Inducing miR-155-Mediated Downregulation of SOCS1 and SHIP1. Front Immunol. 2021; 12:607044.

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Kalunke RM, Tundo S, Sestili F, Camerlengo F, Lafiandra D, Lupi R, Larr? C, Denery-Papini S, Islam S, Ma W, D'Amico S, Masci S. Reduction of Allergenic Potential in Bread Wheat RNAi Transgenic Lines Silenced for CM3, CM16 and 0.28ATI Genes. Int J Mol Sci. 2020 Aug 13; 21(16).

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Kharabsheh HA, Scott JE. CoAsy knockdown in TNBC cell lines resulted in no overt effect on cell proliferation in?vitro. Biochem Biophys Res Commun. 2020 09 10; 530(1):136-141.

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Huckins LM, Chatzinakos C, Breen MS, Hartmann J, Klengel T, da Silva Almeida AC, Dobbyn A, Girdhar K, Hoffman GE, Klengel C, Logue MW, Lori A, Maihofer AX, Morrison FG, Nguyen HT, Park Y, Ruderfer D, Sloofman LG, van Rooij SJH, Baker DG, Chen CY, Cox N, Duncan LE, Geyer MA, Glatt SJ, Im HK, Risbrough VB, Smoller JW, Stein DJ, Yehuda R, Liberzon I, Koenen KC, Jovanovic T, Kellis M, Miller MW, Bacanu SA, Nievergelt CM, Buxbaum JD, Sklar P, Ressler KJ, Stahl EA, Daskalakis NP. Analysis of Genetically Regulated Gene Expression Identifies a Prefrontal PTSD Gene, SNRNP35, Specific to Military Cohorts. Cell Rep. 2020 06 02; 31(9):107716.

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