Small double-stranded, non-protein coding RNAs (21-31 nucleotides) involved in GENE SILENCING functions, especially RNA INTERFERENCE (RNAi). Endogenously, siRNAs are generated from dsRNAs (RNA, DOUBLE-STRANDED) by the same ribonuclease, Dicer, that generates miRNAs (MICRORNAS). The perfect match of the siRNAs' antisense strand to their target RNAs mediates RNAi by siRNA-guided RNA cleavage. siRNAs fall into different classes including trans-acting siRNA (tasiRNA), repeat-associated RNA (rasiRNA), small-scan RNA (scnRNA), and Piwi protein-interacting RNA (piRNA) and have different specific gene silencing functions.

Descriptor ID	D034741
MeSH Number(s)	D13.150.650.700 D13.444.735.150.700 D13.444.735.790.552.875
Concept/Terms	RNA, Small Interfering RNA, Small Interfering Interfering RNA, Small Short Interfering RNA Interfering RNA, Short RNA, Short Interfering Small Interfering RNA siRNA Piwi-Interacting RNA Piwi-Interacting RNA Piwi Interacting RNA RNA, Piwi-Interacting RNA, Piwi Interacting piRNA Short Hairpin RNA Short Hairpin RNA Hairpin RNA, Short RNA, Short Hairpin Small Hairpin RNA Hairpin RNA, Small RNA, Small Hairpin shRNA Repeat-Associated siRNA Repeat-Associated siRNA Repeat Associated siRNA siRNA, Repeat-Associated siRNA, Repeat Associated Scan RNA Scan RNA scnRNA Small Scan RNA RNA, Small Scan Scan RNA, Small RNA, Scan Trans-Acting siRNA Trans-Acting siRNA Trans Acting siRNA tasiRNA siRNA, Trans-Acting siRNA, Trans Acting

Below are MeSH descriptors whose meaning is more general than "RNA, Small Interfering".

Below are MeSH descriptors whose meaning is related to "RNA, Small Interfering".

Below are MeSH descriptors whose meaning is more specific than "RNA, Small Interfering".