Cisplatin

"Cisplatin" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus, MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure, which enables searching at various levels of specificity.

MeSH information

Definition | Details | More General Concepts | Related Concepts | More Specific Concepts

An inorganic and water-soluble platinum complex. After undergoing hydrolysis, it reacts with DNA to produce both intra and interstrand crosslinks. These crosslinks appear to impair replication and transcription of DNA. The cytotoxicity of cisplatin correlates with cellular arrest in the G2 phase of the cell cycle.

Descriptor ID	D002945
MeSH Number(s)	D01.210.375 D01.625.125 D01.710.100
Concept/Terms	Cisplatin Cisplatin cis-Diamminedichloroplatinum(II) Platinum Diamminodichloride Diamminodichloride, Platinum cis-Platinum cis Platinum Dichlorodiammineplatinum cis-Diamminedichloroplatinum cis Diamminedichloroplatinum cis-Dichlorodiammineplatinum(II) NSC-119875 NSC-119875 Platino Platino Platinol Platinol Biocisplatinum Biocisplatinum Platidiam Platidiam

Below are MeSH descriptors whose meaning is more general than "Cisplatin".

Chemicals and Drugs [D]
Inorganic Chemicals [D01]
Chlorine Compounds [D01.210]
Cisplatin [D01.210.375]
Nitrogen Compounds [D01.625]
Cisplatin [D01.625.125]
Platinum Compounds [D01.710]
Cisplatin [D01.710.100]

Below are MeSH descriptors whose meaning is related to "Cisplatin".

Below are MeSH descriptors whose meaning is more specific than "Cisplatin".

publications

Timeline | Most Recent

This graph shows the total number of publications written about "Cisplatin" by people in this website by year, and whether "Cisplatin" was a major or minor topic of these publications.

Bar chart showing 61 publications over 23 distinct years, with a maximum of 5 publications in 2005 and 2013 and 2015

To see the data from this visualization as text, click here.

Year	Major Topic	Minor Topic	Total
1995	0	1	1
2000	0	1	1
2001	1	0	1
2002	0	1	1
2003	1	0	1
2004	1	2	3
2005	2	3	5
2006	1	0	1
2007	0	1	1
2009	0	1	1
2010	2	2	4
2011	2	1	3
2012	2	1	3
2013	3	2	5
2014	2	0	2
2015	3	2	5
2016	0	4	4
2017	3	0	3
2018	2	1	3
2019	1	2	3
2020	0	4	4
2022	2	2	4
2023	1	1	2

Below are the most recent publications written about "Cisplatin" by people in Profiles.

Anchoori RK, Anchoori V, Lam B, Tseng SH, Das S, Velasquez FC, Karanam B, Poddatoori D, Patnam R, Rudek MA, Chang YN, Roden RBS. Development and anticancer properties of Up284, a spirocyclic candidate ADRM1/RPN13 inhibitor. PLoS One. 2023; 18(6):e0285221.

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Matilionyte G, Forsyth G, Guo J, Rimmer MP, Hermann BP, Anderson RA, Mitchell RT. Granulocyte-colony stimulating factor does not prevent in vitro cisplatin-induced germ cell reduction in immature human and mouse testis. BMC Cancer. 2023 Mar 16; 23(1):251.

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Kumar S, Tchounwou PB. p53 as a unique target of action of cisplatin in acute leukaemia cells. J Cell Mol Med. 2022 09; 26(17):4727-4739.

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Yin Q, Zhao YJ, Ni WJ, Tang TT, Wang Y, Cao JY, Yin D, Wen Y, Li ZL, Zhang YL, Jiang W, Zhang Y, Lu XY, Zhang AQ, Gan WH, Lv LL, Liu BC, Wang B. MiR-155 deficiency protects renal tubular epithelial cells from telomeric and genomic DNA damage in cisplatin-induced acute kidney injury. Theranostics. 2022; 12(10):4753-4766.

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Dasari S, Njiki S, Mbemi A, Yedjou CG, Tchounwou PB. Pharmacological Effects of Cisplatin Combination with Natural Products in Cancer Chemotherapy. Int J Mol Sci. 2022 Jan 28; 23(3).

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Rabelo-Fern?ndez RJ, Santiago-S?nchez GS, Sharma RK, Roche-Lima A, Carrion KC, Rivera RAN, Qui?ones-D?az BI, Rajasekaran S, Siddiqui J, Miles W, Rivera YS, Valiyeva F, Vivas-Mejia PE. Reduced RBPMS Levels Promote Cell Proliferation and Decrease Cisplatin Sensitivity in Ovarian Cancer Cells. Int J Mol Sci. 2022 Jan 04; 23(1).

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Chambers LM, Kuznicki M, Yao M, Chichura A, Gruner M, Reizes O, Debernardo R, Rose PG, Michener C, Vargas R. Impact of antibiotic treatment during platinum chemotherapy on survival and recurrence in women with advanced epithelial ovarian cancer. Gynecol Oncol. 2020 12; 159(3):699-705.

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Alyami M, Bonnot PE, Mercier F, Laplace N, Villeneuve L, Passot G, Bakrin N, Kepenekian V, Glehen O. Pressurized intraperitoneal aerosol chemotherapy (PIPAC) for unresectable peritoneal metastasis from gastric cancer. Eur J Surg Oncol. 2021 01; 47(1):123-127.

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Huang T, Cheng X, Chahoud J, Sarhan A, Tamboli P, Rao P, Guo M, Manyam G, Zhang L, Xiang Y, Han L, Shang X, Deng P, Luo Y, Lu X, Feng S, Ferrer MM, Alan Wang Y, DePinho RA, Pettaway CA, Lu X. Effective combinatorial immunotherapy for penile squamous cell carcinoma. Nat Commun. 2020 05 01; 11(1):2124.

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Lamboy-Caraballo R, Ortiz-Sanchez C, Acevedo-Santiago A, Matta J, N A Monteiro A, N Armaiz-Pena G. Norepinephrine-Induced DNA Damage in Ovarian Cancer Cells. Int J Mol Sci. 2020 Mar 24; 21(6).

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