Potassium Channel Blockers

"Potassium Channel Blockers" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus, MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure, which enables searching at various levels of specificity.

MeSH information

Definition | Details | More General Concepts | Related Concepts | More Specific Concepts

A class of drugs that act by inhibition of potassium efflux through cell membranes. Blockade of potassium channels prolongs the duration of ACTION POTENTIALS. They are used as ANTI-ARRHYTHMIA AGENTS and VASODILATOR AGENTS.

Descriptor ID	D026902
MeSH Number(s)	D27.505.519.562.500 D27.505.954.411.645
Concept/Terms	Potassium Channel Blockers Potassium Channel Blockers Blockers, Potassium Channel Channel Blockers, Potassium

Below are MeSH descriptors whose meaning is more general than "Potassium Channel Blockers".

Chemicals and Drugs [D]
Chemical Actions and Uses [D27]
Pharmacologic Actions [D27.505]
Molecular Mechanisms of Pharmacological Action [D27.505.519]
Membrane Transport Modulators [D27.505.519.562]
Potassium Channel Blockers [D27.505.519.562.500]
Therapeutic Uses [D27.505.954]
Cardiovascular Agents [D27.505.954.411]
Potassium Channel Blockers [D27.505.954.411.645]

Below are MeSH descriptors whose meaning is more specific than "Potassium Channel Blockers".

publications

Timeline | Most Recent

This graph shows the total number of publications written about "Potassium Channel Blockers" by people in this website by year, and whether "Potassium Channel Blockers" was a major or minor topic of these publications.

Bar chart showing 28 publications over 17 distinct years, with a maximum of 3 publications in 2007 and 2011 and 2014 and 2017

To see the data from this visualization as text, click here.

Year	Major Topic	Minor Topic	Total
1998	0	1	1
2003	2	0	2
2005	0	1	1
2006	1	1	2
2007	0	3	3
2008	0	1	1
2009	0	1	1
2010	0	2	2
2011	0	3	3
2012	1	0	1
2013	0	1	1
2014	0	3	3
2015	1	0	1
2016	0	1	1
2017	2	1	3
2018	0	1	1
2021	1	0	1

Below are the most recent publications written about "Potassium Channel Blockers" by people in Profiles.

Jiang J, Ding FX, Zhou X, Bateman TJ, Dong S, Gu X, Keh deJesus R, Pio B, Tang H, Chobanian HR, Levorse D, Hu M, Thomas-Fowlkes B, Margulis M, Koehler M, Weinglass A, Gibson J, Houle K, Yudkovitz J, Hampton C, Pai LY, Samuel K, Cutarelli T, Sullivan K, Parmee ER, Davies I, Pasternak A. Discovery of MK-8153, a Potent and Selective ROMK Inhibitor and Novel Diuretic/Natriuretic. J Med Chem. 2021 06 10; 64(11):7691-7701.

View in: PubMed
Lombardo J, Sun J, Harrington MA. Rapid activity-dependent modulation of the intrinsic excitability through up-regulation of KCNQ/Kv7 channel function in neonatal spinal motoneurons. PLoS One. 2018; 13(3):e0193948.

View in: PubMed
Zou L, Xue Y, Jones M, Heinbockel T, Ying M, Zhan X. The Effects of Quinine on Neurophysiological Properties of Dopaminergic Neurons. Neurotox Res. 2018 07; 34(1):62-73.

View in: PubMed
Dong S, VanGelder K, Shi ZC, Yu Y, Wu Z, Ferguson R, Guo ZZ, Tang H, Frie J, Fu Q, Gu X, Priest BT, Thomas-Fowlkes B, Weinglass A, Margulis M, Liu J, Pai LY, Hampton C, Haimbach RE, Owens K, Tong V, Xu S, Hu M, Zingaro GJ, Morissette P, Ehrhart J, Roy S, Sullivan K, Pasternak A. Improvement of hERG-ROMK index of spirocyclic ROMK inhibitors through scaffold optimization and incorporation of novel pharmacophores. Bioorg Med Chem Lett. 2017 06 01; 27(11):2559-2566.

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Araujo M, Welch WJ, Zhou X, Sullivan K, Walsh S, Pasternak A, Wilcox CS. Inhibition of ROMK blocks macula densa tubuloglomerular feedback yet causes renal vasoconstriction in anesthetized rats. Am J Physiol Renal Physiol. 2017 06 01; 312(6):F1120-F1127.

View in: PubMed
Wang B, Bugay V, Ling L, Chuang HH, Jaffe DB, Brenner R. Knockout of the BK ?4-subunit promotes a functional coupling of BK channels and ryanodine receptors that mediate a fAHP-induced increase in excitability. J Neurophysiol. 2016 08 01; 116(2):456-65.

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B?ez A, Salceda E, Fl? M, Gra?a M, Fern?ndez C, Vega R, Soto E. a-Dendrotoxin inhibits the ASIC current in dorsal root ganglion neurons from rat. Neurosci Lett. 2015 Oct 08; 606:42-7.

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Vel?squez-Mart?nez MC, V?zquez-Torres R, Rojas LV, Sanabria P, Jim?nez-Rivera CA. Alpha-1 adrenoreceptors modulate GABA release onto ventral tegmental area dopamine neurons. Neuropharmacology. 2015 Jan; 88:110-21.

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Salinas K, Kereselidze Z, DeLuna F, Peralta XG, Santamaria F. Transient extracellular application of gold nanostars increases hippocampal neuronal activity. J Nanobiotechnology. 2014 Aug 20; 12:31.

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Baskaran P, Thyagarajan B. Acute and chronic effects of botulinum neurotoxin a on the mammalian neuromuscular junction. Muscle Nerve. 2014 Aug; 50(2):206-15.

View in: PubMed

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