"Genes, Immunoglobulin" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
Genes encoding the different subunits of the IMMUNOGLOBULINS, for example the IMMUNOGLOBULIN LIGHT CHAIN GENES and the IMMUNOGLOBULIN HEAVY CHAIN GENES. The heavy and light immunoglobulin genes are present as gene segments in the germline cells. The completed genes are created when the segments are shuffled and assembled (B-LYMPHOCYTE GENE REARRANGEMENT) during B-LYMPHOCYTE maturation. The gene segments of the human light and heavy chain germline genes are symbolized V (variable), J (joining) and C (constant). The heavy chain germline genes have an additional segment D (diversity).
| Descriptor ID |
D005803
|
| MeSH Number(s) |
G05.360.340.024.340.335 G12.500.299
|
| Concept/Terms |
Genes, Immunoglobulin- Genes, Immunoglobulin
- Immunoglobulin Genes
- Gene, Immunoglobulin
- Immunoglobulin Gene
- Genes, Ig
- Gene, Ig
- Ig Gene
- Ig Genes
|
Below are MeSH descriptors whose meaning is more general than "Genes, Immunoglobulin".
Below are MeSH descriptors whose meaning is more specific than "Genes, Immunoglobulin".
This graph shows the total number of publications written about "Genes, Immunoglobulin" by people in this website by year, and whether "Genes, Immunoglobulin" was a major or minor topic of these publications.
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| Year | Major Topic | Minor Topic | Total |
|---|
| 1994 | 3 | 1 | 4 |
| 1995 | 2 | 3 | 5 |
| 1997 | 2 | 1 | 3 |
| 1998 | 2 | 0 | 2 |
| 1999 | 1 | 0 | 1 |
| 2001 | 2 | 0 | 2 |
| 2005 | 0 | 1 | 1 |
| 2019 | 0 | 1 | 1 |
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Below are the most recent publications written about "Genes, Immunoglobulin" by people in Profiles.
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Choi JE, Matthews AJ, Michel G, Vuong BQ. AID Phosphorylation Regulates Mismatch Repair-Dependent Class Switch Recombination and Affinity Maturation. J Immunol. 2020 01 01; 204(1):13-22.
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Calin GA, Ferracin M, Cimmino A, Di Leva G, Shimizu M, Wojcik SE, Iorio MV, Visone R, Sever NI, Fabbri M, Iuliano R, Palumbo T, Pichiorri F, Roldo C, Garzon R, Sevignani C, Rassenti L, Alder H, Volinia S, Liu CG, Kipps TJ, Negrini M, Croce CM. A MicroRNA signature associated with prognosis and progression in chronic lymphocytic leukemia. N Engl J Med. 2005 Oct 27; 353(17):1793-801.
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Sharif MN, Radomska HS, Miller DM, Eckhardt LA. Unique function for carboxyl-terminal domain of Oct-2 in Ig-secreting cells. J Immunol. 2001 Oct 15; 167(8):4421-9.
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Ortiz BD, Harrow F, Cado D, Santoso B, Winoto A. Function and factor interactions of a locus control region element in the mouse T cell receptor-alpha/Dad1 gene locus. J Immunol. 2001 Oct 01; 167(7):3836-45.
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Saleque S, Singh M, Birshtein BK. Ig heavy chain expression and class switching in vitro from an allele lacking the 3' enhancers DNase I-hypersensitive hs3A and hs1,2. J Immunol. 1999 Mar 01; 162(5):2791-803.
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Raaphorst FM, Gokmen E, Teale JM. Analysis of clonal diversity in mouse immunoglobulin heavy chain genes selected for size of the antigen combining site. Immunol Invest. 1998 Dec; 27(6):355-65.
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Gokmen E, Raaphorst FM, Boldt DH, Teale JM. Ig heavy chain third complementarity determining regions (H CDR3s) after stem cell transplantation do not resemble the developing human fetal H CDR3s in size distribution and Ig gene utilization. Blood. 1998 Oct 15; 92(8):2802-14.
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Saleque S, Singh M, Little RD, Giannini SL, Michaelson JS, Birshtein BK. Dyad symmetry within the mouse 3' IgH regulatory region includes two virtually identical enhancers (C alpha3'E and hs3). J Immunol. 1997 May 15; 158(10):4780-7.
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Raaphorst FM, Raman CS, Nall BT, Teale JM. Molecular mechanisms governing reading frame choice of immunoglobulin diversity genes. Immunol Today. 1997 Jan; 18(1):37-43.
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Birshtein BK, Chen C, Saleque S, Michaelson JS, Singh M, Little RD. Murine and human 3'IgH regulatory sequences. Curr Top Microbiol Immunol. 1997; 224:73-80.