"Antibody Diversity" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
The phenomenon of immense variability characteristic of ANTIBODIES. It enables the IMMUNE SYSTEM to react specifically against the essentially unlimited kinds of ANTIGENS it encounters. Antibody diversity is accounted for by three main theories: (1) the Germ Line Theory, which holds that each antibody-producing cell has genes coding for all possible antibody specificities, but expresses only the one stimulated by antigen; (2) the Somatic Mutation Theory, which holds that antibody-producing cells contain only a few genes, which produce antibody diversity by mutation; and (3) the Gene Rearrangement Theory, which holds that antibody diversity is generated by the rearrangement of IMMUNOGLOBULIN VARIABLE REGION gene segments during the differentiation of the ANTIBODY-PRODUCING CELLS.
| Descriptor ID |
D000916
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| MeSH Number(s) |
G05.365.036 G12.500.199
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| Concept/Terms |
Antibody Diversity- Antibody Diversity
- Antibody Diversities
- Diversities, Antibody
- Diversity, Antibody
Germ Line Theory- Germ Line Theory
- Germ Line Theories
- Theories, Germ Line
- Theory, Germ Line
|
Below are MeSH descriptors whose meaning is more general than "Antibody Diversity".
Below are MeSH descriptors whose meaning is more specific than "Antibody Diversity".
This graph shows the total number of publications written about "Antibody Diversity" by people in this website by year, and whether "Antibody Diversity" was a major or minor topic of these publications.
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| Year | Major Topic | Minor Topic | Total |
|---|
| 1997 | 1 | 0 | 1 |
| 1998 | 2 | 0 | 2 |
| 2001 | 0 | 2 | 2 |
| 2009 | 0 | 1 | 1 |
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Below are the most recent publications written about "Antibody Diversity" by people in Profiles.
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Freeman JD, Warren RL, Webb JR, Nelson BH, Holt RA. Profiling the T-cell receptor beta-chain repertoire by massively parallel sequencing. Genome Res. 2009 Oct; 19(10):1817-24.
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Gokmen E, Bachier C, Raaphorst FM, Muller T, Armstrong D, LeMaistre CF, Teale JM. Ig heavy chain CDR3 size diversities are similar after conventional peripheral blood and ex vivo expanded hematopoietic cell transplants. Bone Marrow Transplant. 2001 Feb; 27(4):413-24.
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Gokmen E, Bachier C, Raaphorst FM, Muller T, Armstrong D, Lemaistre CF, Teale JM. Ex vivo-expanded hematopoietic cell graft recipients exhibit T cell repertoire diversity similar to that seen after conventional stem cell transplants. J Hematother Stem Cell Res. 2001 Feb; 10(1):53-66.
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Raaphorst FM, Gokmen E, Teale JM. Analysis of clonal diversity in mouse immunoglobulin heavy chain genes selected for size of the antigen combining site. Immunol Invest. 1998 Dec; 27(6):355-65.
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Gokmen E, Raaphorst FM, Boldt DH, Teale JM. Ig heavy chain third complementarity determining regions (H CDR3s) after stem cell transplantation do not resemble the developing human fetal H CDR3s in size distribution and Ig gene utilization. Blood. 1998 Oct 15; 92(8):2802-14.
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Raaphorst FM, Raman CS, Nall BT, Teale JM. Molecular mechanisms governing reading frame choice of immunoglobulin diversity genes. Immunol Today. 1997 Jan; 18(1):37-43.
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Medina CA, Teale JM. Restricted kappa chain expression in early ontogeny: biased utilization of V kappa exons and preferential V kappa-J kappa recombinations. J Exp Med. 1993 May 01; 177(5):1317-30.
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Bangs LA, Sanz IE, Teale JM. Comparison of D, JH, and junctional diversity in the fetal, adult, and aged B cell repertoires. J Immunol. 1991 Mar 15; 146(6):1996-2004.
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Komisar JL, Leung KY, Crawley RR, Talal N, Teale JM. Ig VH gene family repertoire of plasma cells derived from lupus-prone MRL/lpr and MRL/++ mice. J Immunol. 1989 Jul 01; 143(1):340-7.
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Teale JM. Abnormalities in isotype expression in CBA/N mice due to stimulatory environment rather than a B cell defect. J Immunol. 1983 Jan; 130(1):72-7.