Deoxyribonuclease I

"Deoxyribonuclease I" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus, MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure, which enables searching at various levels of specificity.

MeSH information

Definition | Details | More General Concepts | Related Concepts | More Specific Concepts

An enzyme capable of hydrolyzing highly polymerized DNA by splitting phosphodiester linkages, preferentially adjacent to a pyrimidine nucleotide. This catalyzes endonucleolytic cleavage of DNA yielding 5'-phosphodi- and oligonucleotide end-products. The enzyme has a preference for double-stranded DNA.

Descriptor ID	D003850
MeSH Number(s)	D08.811.277.352.335.350.250
Concept/Terms	Deoxyribonuclease I Deoxyribonuclease I DNAase I Pancreatic DNase DNase, Pancreatic Thymonuclease DNA Endonuclease Endonuclease, DNA DNase I Nickase Nickase DNA Nicking Enzyme Endonuclease I T4-Endonuclease II T4-Endonuclease II T4 Endonuclease II T7-Endonuclease I T7-Endonuclease I T7 Endonuclease I Dornavac Dornavac Streptodornase Streptodornase

Below are MeSH descriptors whose meaning is more general than "Deoxyribonuclease I".

Chemicals and Drugs [D]
Enzymes and Coenzymes [D08]
Enzymes [D08.811]
Hydrolases [D08.811.277]
Esterases [D08.811.277.352]
Deoxyribonucleases [D08.811.277.352.335]
Endodeoxyribonucleases [D08.811.277.352.335.350]
Deoxyribonuclease I [D08.811.277.352.335.350.250]

Below are MeSH descriptors whose meaning is related to "Deoxyribonuclease I".

Below are MeSH descriptors whose meaning is more specific than "Deoxyribonuclease I".

Deoxyribonuclease I
Streptodornase and Streptokinase

publications

Timeline | Most Recent

This graph shows the total number of publications written about "Deoxyribonuclease I" by people in this website by year, and whether "Deoxyribonuclease I" was a major or minor topic of these publications.

Bar chart showing 20 publications over 14 distinct years, with a maximum of 2 publications in 2000 and 2003 and 2005 and 2015 and 2021 and 2025

To see the data from this visualization as text, click here.

Year	Major Topic	Minor Topic	Total
1996	0	1	1
1998	0	1	1
1999	1	0	1
2000	0	2	2
2001	0	1	1
2003	1	1	2
2004	0	1	1
2005	0	2	2
2007	0	1	1
2009	0	1	1
2015	1	1	2
2016	0	1	1
2021	1	1	2
2025	2	0	2

Below are the most recent publications written about "Deoxyribonuclease I" by people in Profiles.

Lee HJ, Lee NK, Kim J, Kim J, Seo D, Shin HE, Kim J, Ahn JH, Kim SN, Kim HS, Park J, Park W, Hong KS, Park CG, Lee W. Sequential nanoparticle therapy targeting neutrophil hyperactivation to prevent neutrophil-induced pulmonary fibrosis. J Nanobiotechnology. 2025 May 26; 23(1):381.

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Shin HE, Giannakopoulos S, Park JD, Jang HJ, Park CG, Murphy SV, Park J, Verma S, Park W. Lipid nanoparticles target neutrophils to reduce SARS-CoV-2-induced lung injury and inflammation. J Control Release. 2025 Jun 10; 382:113736.

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Smith LM, Ladner JT, Hodara VL, Parodi LM, Harris RA, Callery JE, Lai Z, Zou Y, Raveedran M, Rogers J, Giavedoni LD. Multiplexed Simian Immunodeficiency Virus-Specific Paired RNA-Guided Cas9 Nickases Inactivate Proviral DNA. J Virol. 2021 Nov 09; 95(23):e0088221.

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Singh D, Oudit O, Hajtovic S, Sarbaugh D, Salis R, Adebowale T, James J, Spatz LA. Antibodies to an Epstein Barr Virus protein that cross-react with dsDNA have pathogenic potential. Mol Immunol. 2021 04; 132:41-52.

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Park J, Wysocki RW, Amoozgar Z, Maiorino L, Fein MR, Jorns J, Schott AF, Kinugasa-Katayama Y, Lee Y, Won NH, Nakasone ES, Hearn SA, K?ttner V, Qiu J, Almeida AS, Perurena N, Kessenbrock K, Goldberg MS, Egeblad M. Cancer cells induce metastasis-supporting neutrophil extracellular DNA traps. Sci Transl Med. 2016 10 19; 8(361):361ra138.

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Kucerov?-Levisohn M, Knirr S, Mejia RI, Ortiz BD. The 3'-Ja Region of the TCRa Locus Bears Gene Regulatory Activity in Thymic and Peripheral T Cells. PLoS One. 2015; 10(7):e0132856.

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Zhdanov DD, Fahmi T, Wang X, Apostolov EO, Sokolov NN, Javadov S, Basnakian AG. Regulation of Apoptotic Endonucleases by EndoG. DNA Cell Biol. 2015 May; 34(5):316-26.

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Guiton PS, Hung CS, Kline KA, Roth R, Kau AL, Hayes E, Heuser J, Dodson KW, Caparon MG, Hultgren SJ. Contribution of autolysin and Sortase a during Enterococcus faecalis DNA-dependent biofilm development. Infect Immun. 2009 Sep; 77(9):3626-38.

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Shaman JA, Yamauchi Y, Ward WS. The sperm nuclear matrix is required for paternal DNA replication. J Cell Biochem. 2007 Oct 15; 102(3):680-8.

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Hermann BP, Heckert LL. Silencing of Fshr occurs through a conserved, hypersensitive site in the first intron. Mol Endocrinol. 2005 Aug; 19(8):2112-31.

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