"Cathepsin D" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
An intracellular proteinase found in a variety of tissue. It has specificity similar to but narrower than that of pepsin A. The enzyme is involved in catabolism of cartilage and connective tissue. EC 3.4.23.5. (Formerly EC 3.4.4.23).
| Descriptor ID |
D002402
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| MeSH Number(s) |
D08.811.277.656.074.500.180 D08.811.277.656.224.187 D08.811.277.656.300.048.180
|
| Concept/Terms |
|
Below are MeSH descriptors whose meaning is more general than "Cathepsin D".
Below are MeSH descriptors whose meaning is more specific than "Cathepsin D".
This graph shows the total number of publications written about "Cathepsin D" by people in this website by year, and whether "Cathepsin D" was a major or minor topic of these publications.
To see the data from this visualization as text,
click here.
| Year | Major Topic | Minor Topic | Total |
|---|
| 1998 | 1 | 0 | 1 |
| 2005 | 0 | 1 | 1 |
| 2006 | 1 | 1 | 2 |
| 2007 | 1 | 0 | 1 |
| 2008 | 0 | 1 | 1 |
| 2014 | 1 | 0 | 1 |
| 2017 | 1 | 0 | 1 |
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click here.
Below are the most recent publications written about "Cathepsin D" by people in Profiles.
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Robak LA, Jansen IE, van Rooij J, Uitterlinden AG, Kraaij R, Jankovic J, Heutink P, Shulman JM. Excessive burden of lysosomal storage disorder gene variants in Parkinson's disease. Brain. 2017 12 01; 140(12):3191-3203.
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Smith B, Randle D, Mezencev R, Thomas L, Hinton C, Odero-Marah V. Camalexin-induced apoptosis in prostate cancer cells involves alterations of expression and activity of lysosomal protease cathepsin D. Molecules. 2014 Apr 02; 19(4):3988-4005.
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Mebratu YA, Dickey BF, Evans C, Tesfaigzi Y. The BH3-only protein Bik/Blk/Nbk inhibits nuclear translocation of activated ERK1/2 to mediate IFNgamma-induced cell death. J Cell Biol. 2008 Nov 03; 183(3):429-39.
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Lee DC, Mason CW, Goodman CB, Holder MS, Kirksey OW, Womble TA, Severs WB, Palm DE. Hydrogen peroxide induces lysosomal protease alterations in PC12 cells. Neurochem Res. 2007 Sep; 32(9):1499-510.
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Lee DC, Womble TA, Mason CW, Jackson IM, Lamango NS, Severs WB, Palm DE. 6-Hydroxydopamine induces cystatin C-mediated cysteine protease suppression and cathepsin D activation. Neurochem Int. 2007 Mar; 50(4):607-18.
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Lee DC, Close FT, Goodman CB, Jackson IM, Wight-Mason C, Wells LM, Womble TA, Palm DE. Enhanced cystatin C and lysosomal protease expression following 6-hydroxydopamine exposure. Neurotoxicology. 2006 Mar; 27(2):260-76.
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Santic M, Molmeret M, Klose KE, Jones S, Kwaik YA. The Francisella tularensis pathogenicity island protein IglC and its regulator MglA are essential for modulating phagosome biogenesis and subsequent bacterial escape into the cytoplasm. Cell Microbiol. 2005 Jul; 7(7):969-79.
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Godbold GD, Ahn K, Yeyeodu S, Lee LF, Ting JP, Erickson AH. Biosynthesis and intracellular targeting of the lysosomal aspartic proteinase cathepsin D. Adv Exp Med Biol. 1998; 436:153-62.