Synaptic Transmission

"Synaptic Transmission" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus, MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure, which enables searching at various levels of specificity.

MeSH information

Definition | Details | More General Concepts | Related Concepts | More Specific Concepts

The communication from a NEURON to a target (neuron, muscle, or secretory cell) across a SYNAPSE. In chemical synaptic transmission, the presynaptic neuron releases a NEUROTRANSMITTER that diffuses across the synaptic cleft and binds to specific synaptic receptors, activating them. The activated receptors modulate specific ion channels and/or second-messenger systems in the postsynaptic cell. In electrical synaptic transmission, electrical signals are communicated as an ionic current flow across ELECTRICAL SYNAPSES.

Descriptor ID	D009435
MeSH Number(s)	G02.111.820.850 G04.835.850 G07.265.880 G11.561.830
Concept/Terms	Synaptic Transmission Synaptic Transmission Neural Transmission Neurotransmission Transmission, Neural Transmission, Synaptic

Below are MeSH descriptors whose meaning is more general than "Synaptic Transmission".

Biological Sciences [G]
Chemical Phenomena [G02]
Biochemical Phenomena [G02.111]
Signal Transduction [G02.111.820]
Synaptic Transmission [G02.111.820.850]
Cell Physiological Phenomena [G04]
Signal Transduction [G04.835]
Synaptic Transmission [G04.835.850]
Physiological Phenomena [G07]
Electrophysiological Phenomena [G07.265]
Synaptic Transmission [G07.265.880]
Musculoskeletal and Neural Physiological Phenomena [G11]
Nervous System Physiological Phenomena [G11.561]
Synaptic Transmission [G11.561.830]

Below are MeSH descriptors whose meaning is related to "Synaptic Transmission".

Below are MeSH descriptors whose meaning is more specific than "Synaptic Transmission".

Synaptic Transmission
Postsynaptic Potential Summation

publications

Timeline | Most Recent

This graph shows the total number of publications written about "Synaptic Transmission" by people in this website by year, and whether "Synaptic Transmission" was a major or minor topic of these publications.

Bar chart showing 126 publications over 28 distinct years, with a maximum of 18 publications in 2006

To see the data from this visualization as text, click here.

Year	Major Topic	Minor Topic	Total
1996	0	1	1
1997	1	2	3
1998	2	3	5
1999	3	0	3
2000	2	2	4
2001	4	4	8
2002	4	4	8
2003	0	4	4
2004	2	6	8
2005	3	1	4
2006	8	10	18
2007	3	5	8
2008	0	4	4
2009	1	4	5
2010	1	5	6
2011	0	1	1
2012	3	3	6
2013	0	4	4
2014	1	2	3
2015	1	2	3
2016	1	1	2
2017	1	1	2
2018	2	1	3
2019	1	2	3
2020	2	1	3
2021	2	0	2
2022	1	3	4
2025	1	0	1

Below are the most recent publications written about "Synaptic Transmission" by people in Profiles.

Kim S, Pajarillo E, Digman A, Ajayi I, Son DS, Aschner M, Lee E. Role of dopaminergic RE1-silencing transcription factor (REST) in manganese-induced behavioral deficits and dysregulating dopaminergic and serotonergic neurotransmission in mice. Neurotoxicology. 2025 May; 108:57-68.

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Sabandal PR, Saldes EB, Han KA. Acetylcholine deficit causes dysfunctional inhibitory control in an aging-dependent manner. Sci Rep. 2022 12 03; 12(1):20903.

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Casello SM, Flores RJ, Yarur HE, Wang H, Awanyai M, Arenivar MA, Jaime-Lara RB, Bravo-Rivera H, Tejeda HA. Neuropeptide System Regulation of Prefrontal Cortex Circuitry: Implications for Neuropsychiatric Disorders. Front Neural Circuits. 2022; 16:796443.

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Xu C, Yadav-Samudrala BJ, Xu C, Nath B, Mistry T, Jiang W, Niphakis MJ, Cravatt BF, Mukhopadhyay S, Lichtman AH, Ignatowska-Jankowska BM, Fitting S. Inhibitory Neurotransmission Is Sex-Dependently Affected by Tat Expression in Transgenic Mice and Suppressed by the Fatty Acid Amide Hydrolase Enzyme Inhibitor PF3845 via Cannabinoid Type-1 Receptor Mechanisms. Cells. 2022 03 02; 11(5).

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Tejeda HA, Wang H, Flores RJ, Yarur HE. Dynorphin/Kappa-Opioid Receptor System Modulation of Cortical Circuitry. Handb Exp Pharmacol. 2022; 271:223-253.

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Maldonado-D?az C, Vazquez M, Marie B. A comparison of three different methods of eliciting rapid activity-dependent synaptic plasticity at the Drosophila NMJ. PLoS One. 2021; 16(11):e0260553.

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Owen B, Bichler E, Benveniste M. Excitatory synaptic transmission in hippocampal area CA1 is enhanced then reduced as chronic epilepsy progresses. Neurobiol Dis. 2021 07; 154:105343.

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White D, de Sousa Abreu RP, Blake A, Murphy J, Showell S, Kitamoto T, Lawal HO. Deficits in the vesicular acetylcholine transporter alter lifespan and behavior in adult Drosophila melanogaster. Neurochem Int. 2020 07; 137:104744.

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Ye H, Ojelade SA, Li-Kroeger D, Zuo Z, Wang L, Li Y, Gu JY, Tepass U, Rodal AA, Bellen HJ, Shulman JM. Retromer subunit, VPS29, regulates synaptic transmission and is required for endolysosomal function in the aging brain. Elife. 2020 04 14; 9.

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Showell SS, Martinez Y, Gondolfo S, Boppana S, Lawal HO. Overexpression of the vesicular acetylcholine transporter disrupts cognitive performance and causes age-dependent locomotion decline in Drosophila. Mol Cell Neurosci. 2020 06; 105:103483.

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