Immunoglobulin Heavy Chains

"Immunoglobulin Heavy Chains" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus, MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure, which enables searching at various levels of specificity.

MeSH information

Definition | Details | More General Concepts | Related Concepts | More Specific Concepts

The largest of polypeptide chains comprising immunoglobulins. They contain 450 to 600 amino acid residues per chain, and have molecular weights of 51-72 kDa.

Descriptor ID	D007143
MeSH Number(s)	D12.776.124.486.485.705.500 D12.776.124.790.651.705.500 D12.776.377.715.548.705.500
Concept/Terms	Immunoglobulin Heavy Chains Immunoglobulin Heavy Chains Heavy Chains, Immunoglobulin Ig Heavy Chains Heavy Chains, Ig Immunoglobulins, Heavy-Chain Immunoglobulins, Heavy Chain Heavy-Chain Immunoglobulins Heavy Chain Immunoglobulins Immunoglobulin Heavy Chain Heavy Chain, Immunoglobulin Immunoglobulin Heavy Chain Subgroup VH-III Immunoglobulin Heavy Chain Subgroup VH-III Immunoglobulin Heavy Chain Subgroup VH III Immunoglobulin Heavy Chain Subgroup VH-I Immunoglobulin Heavy Chain Subgroup VH-I Immunoglobulin Heavy Chain Subgroup VH I

Below are MeSH descriptors whose meaning is more general than "Immunoglobulin Heavy Chains".

Chemicals and Drugs [D]
Amino Acids, Peptides, and Proteins [D12]
Proteins [D12.776]
Blood Proteins [D12.776.124]
Immunoproteins [D12.776.124.486]
Immunoglobulins [D12.776.124.486.485]
Immunoglobulin Subunits [D12.776.124.486.485.705]
Immunoglobulin Heavy Chains [D12.776.124.486.485.705.500]
Serum Globulins [D12.776.124.790]
Immunoglobulins [D12.776.124.790.651]
Immunoglobulin Subunits [D12.776.124.790.651.705]
Immunoglobulin Heavy Chains [D12.776.124.790.651.705.500]
Globulins [D12.776.377]
Serum Globulins [D12.776.377.715]
Immunoglobulins [D12.776.377.715.548]
Immunoglobulin Subunits [D12.776.377.715.548.705]
Immunoglobulin Heavy Chains [D12.776.377.715.548.705.500]

Below are MeSH descriptors whose meaning is related to "Immunoglobulin Heavy Chains".

Below are MeSH descriptors whose meaning is more specific than "Immunoglobulin Heavy Chains".

publications

Timeline | Most Recent

This graph shows the total number of publications written about "Immunoglobulin Heavy Chains" by people in this website by year, and whether "Immunoglobulin Heavy Chains" was a major or minor topic of these publications.

Bar chart showing 37 publications over 22 distinct years, with a maximum of 4 publications in 1997 and 2013

To see the data from this visualization as text, click here.

Year	Major Topic	Minor Topic	Total
1994	2	0	2
1995	0	1	1
1996	1	0	1
1997	4	0	4
1998	3	0	3
1999	1	0	1
2000	1	0	1
2001	2	0	2
2002	1	0	1
2003	1	1	2
2004	1	0	1
2005	2	0	2
2007	2	0	2
2008	0	1	1
2011	1	0	1
2013	3	1	4
2014	1	0	1
2015	1	1	2
2018	1	0	1
2021	0	1	1
2022	1	1	2
2023	1	0	1

Below are the most recent publications written about "Immunoglobulin Heavy Chains" by people in Profiles.

Martin OA, Thomas M, Marquet M, Bruzeau C, Garot A, Brousse M, Bender S, Carrion C, Choi JE, Vuong BQ, Gearhart PJ, Maul RW, Le Noir S, Pinaud E. The IgH E?-MAR regions promote UNG-dependent error-prone repair to optimize somatic hypermutation. Front Immunol. 2023; 14:1030813.

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Jaffe DB, Shahi P, Adams BA, Chrisman AM, Finnegan PM, Raman N, Royall AE, Tsai F, Vollbrecht T, Reyes DS, Hepler NL, McDonnell WJ. Functional antibodies exhibit light chain coherence. Nature. 2022 Nov; 611(7935):352-357.

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Ii T, Chambers JK, Nakashima K, Goto-Koshino Y, Mizuno T, Uchida K. Intraepithelial cytotoxic lymphocytes are associated with a poor prognosis in feline intestinal T-cell lymphoma. Vet Pathol. 2022 11; 59(6):931-939.

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van Dijk AD, Griffen TL, Qiu YH, Hoff FW, Toro E, Ruiz K, Ruvolo PP, Lillard JW, de Bont ESJM, Burger JA, Wierda W, Kornblau SM. RPPA-based proteomics recognizes distinct epigenetic signatures in chronic lymphocytic leukemia with clinical consequences. Leukemia. 2022 03; 36(3):712-722.

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Zheng S, Kusnadi A, Choi JE, Vuong BQ, Rhodes D, Chaudhuri J. NME proteins regulate class switch recombination. FEBS Lett. 2019 01; 593(1):80-87.

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Derfalvi B, Maurer K, McDonald McGinn DM, Zackai E, Meng W, Luning Prak ET, Sullivan KE. B cell development in chromosome 22q11.2 deletion syndrome. Clin Immunol. 2016 Feb; 163:1-9.

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Work TM, Dagenais J, Breeden R, Schneemann A, Sung J, Hew B, Balazs GH, Berestecky JM. Green Turtles (Chelonia mydas) Have Novel Asymmetrical Antibodies. J Immunol. 2015 Dec 01; 195(11):5452-60.

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Whittle JR, Wheatley AK, Wu L, Lingwood D, Kanekiyo M, Ma SS, Narpala SR, Yassine HM, Frank GM, Yewdell JW, Ledgerwood JE, Wei CJ, McDermott AB, Graham BS, Koup RA, Nabel GJ. Flow cytometry reveals that H5N1 vaccination elicits cross-reactive stem-directed antibodies from multiple Ig heavy-chain lineages. J Virol. 2014 Apr; 88(8):4047-57.

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Vuong BQ, Herrick-Reynolds K, Vaidyanathan B, Pucella JN, Ucher AJ, Donghia NM, Gu X, Nicolas L, Nowak U, Rahman N, Strout MP, Mills KD, Stavnezer J, Chaudhuri J. A DNA break- and phosphorylation-dependent positive feedback loop promotes immunoglobulin class-switch recombination. Nat Immunol. 2013 Nov; 14(11):1183-1189.

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Peng C, Eckhardt LA. Role of the Igh intronic enhancer E? in clonal selection at the pre-B to immature B cell transition. J Immunol. 2013 Oct 15; 191(8):4399-411.

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