Aromatase

"Aromatase" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus, MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure, which enables searching at various levels of specificity.

MeSH information

Definition | Details | More General Concepts | Related Concepts | More Specific Concepts

An enzyme that catalyzes the desaturation (aromatization) of the ring A of C19 androgens and converts them to C18 estrogens. In this process, the 19-methyl is removed. This enzyme is membrane-bound, located in the endoplasmic reticulum of estrogen-producing cells of ovaries, placenta, testes, adipose, and brain tissues. Aromatase is encoded by the CYP19 gene, and functions in complex with NADPH-FERRIHEMOPROTEIN REDUCTASE in the cytochrome P-450 system.

Descriptor ID	D001141
MeSH Number(s)	D08.244.453.489.500 D08.244.453.915.099 D08.811.682.690.708.170.447.500 D08.811.682.690.708.170.915.099 D12.776.422.220.453.489.500 D12.776.422.220.453.915.099
Concept/Terms	Aromatase Aromatase Estrogen Synthetase Estrogen Synthase Cytochrome P450 19 CYP19 Protein Protein, CYP19 Cytochrome P-450(AROM) CYP 19 Cytochrome P-450 CYP19 Cytochrome P 450 CYP19 P450AROM Androstenedione Aromatase Aromatase, Androstenedione CYP19

Below are MeSH descriptors whose meaning is more general than "Aromatase".

Chemicals and Drugs [D]
Enzymes and Coenzymes [D08]
Cytochromes [D08.244]
Cytochrome P-450 Enzyme System [D08.244.453]
Cytochrome P450 Family 19 [D08.244.453.489]
Aromatase [D08.244.453.489.500]
Steroid Hydroxylases [D08.244.453.915]
Aromatase [D08.244.453.915.099]
Enzymes [D08.811]
Oxidoreductases [D08.811.682]
Oxygenases [D08.811.682.690]
Mixed Function Oxygenases [D08.811.682.690.708]
Cytochrome P-450 Enzyme System [D08.811.682.690.708.170]
Cytochrome P450 Family 19 [D08.811.682.690.708.170.447]
Aromatase [D08.811.682.690.708.170.447.500]
Steroid Hydroxylases [D08.811.682.690.708.170.915]
Aromatase [D08.811.682.690.708.170.915.099]
Amino Acids, Peptides, and Proteins [D12]
Proteins [D12.776]
Hemeproteins [D12.776.422]
Cytochromes [D12.776.422.220]
Cytochrome P-450 Enzyme System [D12.776.422.220.453]
Cytochrome P450 Family 19 [D12.776.422.220.453.489]
Aromatase [D12.776.422.220.453.489.500]
Steroid Hydroxylases [D12.776.422.220.453.915]
Aromatase [D12.776.422.220.453.915.099]

Below are MeSH descriptors whose meaning is related to "Aromatase".

Below are MeSH descriptors whose meaning is more specific than "Aromatase".

publications

Timeline | Most Recent

This graph shows the total number of publications written about "Aromatase" by people in this website by year, and whether "Aromatase" was a major or minor topic of these publications.

Bar chart showing 19 publications over 13 distinct years, with a maximum of 3 publications in 2005 and 2010

To see the data from this visualization as text, click here.

Year	Major Topic	Minor Topic	Total
1998	0	1	1
2003	1	0	1
2005	1	2	3
2006	0	1	1
2007	1	0	1
2009	1	0	1
2010	1	2	3
2011	1	1	2
2012	0	1	1
2013	0	2	2
2014	0	1	1
2018	0	1	1
2022	0	1	1

Below are the most recent publications written about "Aromatase" by people in Profiles.

Walker RR, Patel JR, Gupta A, Davidson AM, Williams CC, Payton-Stewart F, Bou? SM, Burow ME, Khupse R, Tilghman SL. Glyceollins Trigger Anti-Proliferative Effects in Hormone-Dependent Aromatase-Inhibitor-Resistant Breast Cancer Cells through the Induction of Apoptosis. Int J Mol Sci. 2022 Mar 07; 23(5).

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Zhang M, Park EJ, Kondratyuk TP, Pezzuto JM, Sun D. Synthesis and Structure-Activity Relationships of Tetrahydro-?-carboline Derivatives as Anticancer and Cancer-chemopreventive Agents. Anticancer Res. 2018 Aug; 38(8):4425-4433.

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Sato BL, Ward MA, Astern JM, Kendal-Wright CE, Collier AC. Validation of murine and human placental explant cultures for use in sex steroid and phase II conjugation toxicology studies. Toxicol In Vitro. 2015 Feb; 29(1):103-12.

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Jiang Q, Zheng S, Wang G. Development of new estrogen receptor-targeting therapeutic agents for tamoxifen-resistant breast cancer. Future Med Chem. 2013 Jun; 5(9):1023-35.

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Ghosh S, Ashcraft K, Jahid MJ, April C, Ghajar CM, Ruan J, Wang H, Foster M, Hughes DC, Ramirez AG, Huang T, Fan JB, Hu Y, Li R. Regulation of adipose oestrogen output by mechanical stress. Nat Commun. 2013; 4:1821.

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Sugawara A, Sato B, Bal E, Collier AC, Ward MA. Blastomere removal from cleavage-stage mouse embryos alters steroid metabolism during pregnancy. Biol Reprod. 2012 Jul; 87(1):4, 1-9.

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Edwards TL, Velez Edwards DR, Villegas R, Cohen SS, Buchowski MS, Fowke JH, Schlundt D, Long J, Long JR, Cai Q, Zheng W, Shu XO, Hargreaves MK, Smith J, Jeffrey S, Williams SM, Signorello LB, Blot WJ, Matthews CE. HTR1B, ADIPOR1, PPARGC1A, and CYP19A1 and obesity in a cohort of Caucasians and African Americans: an evaluation of gene-environment interactions and candidate genes. Am J Epidemiol. 2012 Jan 01; 175(1):11-21.

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Shen L, Park EJ, Kondratyuk TP, Guendisch D, Marler L, Pezzuto JM, Wright AD, Sun D. Design, synthesis, and biological evaluation of callophycin A and analogues as potential chemopreventive and anticancer agents. Bioorg Med Chem. 2011 Nov 01; 19(21):6182-95.

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Mah V, Marquez D, Alavi M, Maresh EL, Zhang L, Yoon N, Horvath S, Bagryanova L, Fishbein MC, Chia D, Pietras R, Goodglick L. Expression levels of estrogen receptor beta in conjunction with aromatase predict survival in non-small cell lung cancer. Lung Cancer. 2011 Nov; 74(2):318-25.

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Son DS, Terranova PF, Roby KF. Interaction of adenosine 3',5'-cyclic monophosphate and tumor necrosis factor-alpha on serum amyloid A3 expression in mouse granulosa cells: dependence on CCAAT-enhancing binding protein-beta isoform. Endocrinology. 2010 Jul; 151(7):3407-19.

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