Inositol 1,4,5-Trisphosphate Receptors

"Inositol 1,4,5-Trisphosphate Receptors" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus, MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure, which enables searching at various levels of specificity.

MeSH information

Definition | Details | More General Concepts | Related Concepts | More Specific Concepts

Intracellular receptors that bind to INOSITOL 1,4,5-TRISPHOSPHATE and play an important role in its intracellular signaling. Inositol 1,4,5-trisphosphate receptors are calcium channels that release CALCIUM in response to increased levels of inositol 1,4,5-trisphosphate in the CYTOPLASM.

Descriptor ID	D053496
MeSH Number(s)	D12.776.157.530.400.150.760 D12.776.543.550.450.150.760 D12.776.543.585.400.150.760 D12.776.826.179
Concept/Terms	Inositol 1,4,5-Trisphosphate Receptors Inositol 1,4,5-Trisphosphate Receptors INSP3 Receptor Receptor, INSP3 IP3 Receptor Receptor, IP3 Inositol 1,4,5-Triphosphate Receptors Receptor, Inositol-1,4,5-triphosphate Inositol-1,4,5-Triphosphate Receptor 1,4,5-INTP Receptor Inositol Triphosphate Receptor Receptor, Inositol Triphosphate Triphosphate Receptor, Inositol Inositol 1,4,5-trisphosphate Receptor Type 1 Inositol 1,4,5-trisphosphate Receptor Type 1 INSP3 Receptor Type 1 Type 1 Inositol 1,4,5-trisphosphate Receptor Inositol 1,4,5-trisphosphate Receptor Type 2 Inositol 1,4,5-trisphosphate Receptor Type 2 INSP3 Receptor Type 2 Inositol 1,4,5-trisphosphate Receptor Type 3 Inositol 1,4,5-trisphosphate Receptor Type 3 Type 3 Inositol 1,4,5-trisphosphate Receptor INSP3 Receptor Type 3 Inositol 1,4,5-trisphosphate Receptor Subtype 3

Below are MeSH descriptors whose meaning is more general than "Inositol 1,4,5-Trisphosphate Receptors".

Chemicals and Drugs [D]
Amino Acids, Peptides, and Proteins [D12]
Proteins [D12.776]
Carrier Proteins [D12.776.157]
Membrane Transport Proteins [D12.776.157.530]
Ion Channels [D12.776.157.530.400]
Calcium Channels [D12.776.157.530.400.150]
Inositol 1,4,5-Trisphosphate Receptors [D12.776.157.530.400.150.760]
Membrane Proteins [D12.776.543]
Membrane Glycoproteins [D12.776.543.550]
Ion Channels [D12.776.543.550.450]
Calcium Channels [D12.776.543.550.450.150]
Inositol 1,4,5-Trisphosphate Receptors [D12.776.543.550.450.150.760]
Membrane Transport Proteins [D12.776.543.585]
Ion Channels [D12.776.543.585.400]
Calcium Channels [D12.776.543.585.400.150]
Inositol 1,4,5-Trisphosphate Receptors [D12.776.543.585.400.150.760]
Receptors, Cytoplasmic and Nuclear [D12.776.826]
Inositol 1,4,5-Trisphosphate Receptors [D12.776.826.179]

Below are MeSH descriptors whose meaning is more specific than "Inositol 1,4,5-Trisphosphate Receptors".

publications

Timeline | Most Recent

This graph shows the total number of publications written about "Inositol 1,4,5-Trisphosphate Receptors" by people in this website by year, and whether "Inositol 1,4,5-Trisphosphate Receptors" was a major or minor topic of these publications.

Bar chart showing 8 publications over 7 distinct years, with a maximum of 2 publications in 2014

To see the data from this visualization as text, click here.

Year	Major Topic	Minor Topic	Total
2000	0	1	1
2003	0	1	1
2013	0	1	1
2014	2	0	2
2015	1	0	1
2017	1	0	1
2018	0	1	1

Below are the most recent publications written about "Inositol 1,4,5-Trisphosphate Receptors" by people in Profiles.

Kabbani N, Nichols RA. Beyond the Channel: Metabotropic Signaling by Nicotinic Receptors. Trends Pharmacol Sci. 2018 04; 39(4):354-366.

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Bononi A, Giorgi C, Patergnani S, Larson D, Verbruggen K, Tanji M, Pellegrini L, Signorato V, Olivetto F, Pastorino S, Nasu M, Napolitano A, Gaudino G, Morris P, Sakamoto G, Ferris LK, Danese A, Raimondi A, Tacchetti C, Kuchay S, Pass HI, Affar EB, Yang H, Pinton P, Carbone M. BAP1 regulates IP3R3-mediated Ca2+ flux to mitochondria suppressing cell transformation. Nature. 2017 06 22; 546(7659):549-553.

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Fredericks GJ, Hoffmann PR. Selenoprotein K and protein palmitoylation. Antioxid Redox Signal. 2015 Oct 01; 23(10):854-62.

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Amaya MJ, Oliveira AG, Schroeder LK, Allgeyer ES, Bewersdorf J, Nathanson MH. Apical localization of inositol 1,4,5-trisphosphate receptors is independent of extended synaptotagmins in hepatocytes. PLoS One. 2014; 9(12):e114043.

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Fredericks GJ, Hoffmann FW, Rose AH, Osterheld HJ, Hess FM, Mercier F, Hoffmann PR. Stable expression and function of the inositol 1,4,5-triphosphate receptor requires palmitoylation by a DHHC6/selenoprotein K complex. Proc Natl Acad Sci U S A. 2014 Nov 18; 111(46):16478-83.

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Einbond LS, Mighty J, Kashiwazaki R, Figueroa M, Jalees F, Acuna UM, Le Gendre O, Foster DA, Kennelly EJ. Garcinia benzophenones inhibit the growth of human colon cancer cells and synergize with sulindac sulfide and turmeric. Anticancer Agents Med Chem. 2013 Dec; 13(10):1540-50.

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Giorgi C, Ito K, Lin HK, Santangelo C, Wieckowski MR, Lebiedzinska M, Bononi A, Bonora M, Duszynski J, Bernardi R, Rizzuto R, Tacchetti C, Pinton P, Pandolfi PP. PML regulates apoptosis at endoplasmic reticulum by modulating calcium release. Science. 2010 Nov 26; 330(6008):1247-51.

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Rizzuto R, Marchi S, Bonora M, Aguiari P, Bononi A, De Stefani D, Giorgi C, Leo S, Rimessi A, Siviero R, Zecchini E, Pinton P. Ca(2+) transfer from the ER to mitochondria: when, how and why. Biochim Biophys Acta. 2009 Nov; 1787(11):1342-51.

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Turner H, Fleig A, Stokes A, Kinet JP, Penner R. Discrimination of intracellular calcium store subcompartments using TRPV1 (transient receptor potential channel, vanilloid subfamily member 1) release channel activity. Biochem J. 2003 Apr 15; 371(Pt 2):341-50.

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Rond? P, Dougherty JJ, Nichols RA. Functional IP3- and ryanodine-sensitive calcium stores in presynaptic varicosities of NG108-15 (rodent neuroblastoma x glioma hybrid) cells. J Physiol. 2000 Dec 01; 529 Pt 2:307-19.

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