Calcium Channels, L-Type

"Calcium Channels, L-Type" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus, MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure, which enables searching at various levels of specificity.

MeSH information

Definition | Details | More General Concepts | Related Concepts | More Specific Concepts

Long-lasting voltage-gated CALCIUM CHANNELS found in both excitable and nonexcitable tissue. They are responsible for normal myocardial and vascular smooth muscle contractility. Five subunits (alpha-1, alpha-2, beta, gamma, and delta) make up the L-type channel. The alpha-1 subunit is the binding site for calcium-based antagonists. Dihydropyridine-based calcium antagonists are used as markers for these binding sites.

Descriptor ID	D020746
MeSH Number(s)	D12.776.157.530.400.150.400 D12.776.543.550.450.150.400 D12.776.543.585.400.150.400
Concept/Terms	Calcium Channels, L-Type Calcium Channels, L-Type Calcium Channels, L Type L-Type VDCC L Type VDCC VDCC, L-Type L-Type Calcium Channel Calcium Channel, L-Type L Type Calcium Channel L-Type Voltage-Dependent Calcium Channels L Type Voltage Dependent Calcium Channels L-Type Calcium Channels L Type Calcium Channels Long-Lasting Calcium Channels Calcium Channels, Long-Lasting Long Lasting Calcium Channels Receptors, Dihydropyridine Receptors, Dihydropyridine L-Type VDCC alpha-1 Subunit L Type VDCC alpha 1 Subunit Dihydropyridine Receptor Receptor, Dihydropyridine Dihydropyridine Receptors L-Type VDCC delta Subunit L-Type VDCC delta Subunit L Type VDCC delta Subunit L-Type VDCC alpha-2 Subunit L-Type VDCC alpha-2 Subunit L Type VDCC alpha 2 Subunit L-Type VDCC beta Subunit L-Type VDCC beta Subunit L Type VDCC beta Subunit L-Type VDCC gamma Subunit L-Type VDCC gamma Subunit L Type VDCC gamma Subunit

Below are MeSH descriptors whose meaning is more general than "Calcium Channels, L-Type".

Chemicals and Drugs [D]
Amino Acids, Peptides, and Proteins [D12]
Proteins [D12.776]
Carrier Proteins [D12.776.157]
Membrane Transport Proteins [D12.776.157.530]
Ion Channels [D12.776.157.530.400]
Calcium Channels [D12.776.157.530.400.150]
Calcium Channels, L-Type [D12.776.157.530.400.150.400]
Membrane Proteins [D12.776.543]
Membrane Glycoproteins [D12.776.543.550]
Ion Channels [D12.776.543.550.450]
Calcium Channels [D12.776.543.550.450.150]
Calcium Channels, L-Type [D12.776.543.550.450.150.400]
Membrane Transport Proteins [D12.776.543.585]
Ion Channels [D12.776.543.585.400]
Calcium Channels [D12.776.543.585.400.150]
Calcium Channels, L-Type [D12.776.543.585.400.150.400]

Below are MeSH descriptors whose meaning is related to "Calcium Channels, L-Type".

Below are MeSH descriptors whose meaning is more specific than "Calcium Channels, L-Type".

publications

Timeline | Most Recent

This graph shows the total number of publications written about "Calcium Channels, L-Type" by people in this website by year, and whether "Calcium Channels, L-Type" was a major or minor topic of these publications.

Bar chart showing 18 publications over 11 distinct years, with a maximum of 2 publications in 2002 and 2003 and 2005 and 2008 and 2012 and 2013 and 2019

To see the data from this visualization as text, click here.

Year	Major Topic	Minor Topic	Total
2002	1	1	2
2003	1	1	2
2005	0	2	2
2007	0	1	1
2008	1	1	2
2010	0	1	1
2011	1	0	1
2012	1	1	2
2013	1	1	2
2015	1	0	1
2019	2	0	2

Below are the most recent publications written about "Calcium Channels, L-Type" by people in Profiles.

Araki K, Araki A, Honda D, Izumoto T, Hashizume A, Hijikata Y, Yamada S, Iguchi Y, Hara A, Ikumi K, Kawai K, Ishigaki S, Nakamichi Y, Tsunekawa S, Seino Y, Yamamoto A, Takayama Y, Hidaka S, Tominaga M, Ohara-Imaizumi M, Suzuki A, Ishiguro H, Enomoto A, Yoshida M, Arima H, Muramatsu SI, Sobue G, Katsuno M. TDP-43 regulates early-phase insulin secretion via CaV1.2-mediated exocytosis in islets. J Clin Invest. 2019 07 29; 129(9):3578-3593.

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Lai YJ, Zhu BL, Sun F, Luo D, Ma YL, Luo B, Tang J, Xiong MJ, Liu L, Long Y, Hu XT, He L, Deng XJ, Zhang JH, Yang J, Yan Z, Chen GJ. Estrogen receptor a promotes Cav1.2 ubiquitination and degradation in neuronal cells and in APP/PS1 mice. Aging Cell. 2019 08; 18(4):e12961.

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Andres MA, Cooke IM, Bellinger FP, Berry MJ, Zaporteza MM, Rueli RH, Barayuga SM, Chang L. Methamphetamine acutely inhibits voltage-gated calcium channels but chronically up-regulates L-type channels. J Neurochem. 2015 Jul; 134(1):56-65.

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Fanchaouy M, Cubano L, Maldonado H, Bychkov R. PKC independent inhibition of voltage gated calcium channels by volatile anesthetics in freshly isolated vascular myocytes from the aorta. Cell Calcium. 2013 Oct; 54(4):257-65.

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Anastassov I, Shen W, Ripps H, Chappell RL. Zinc modulation of calcium activity at the photoreceptor terminal: a calcium imaging study. Exp Eye Res. 2013 Jul; 112:37-44.

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Pietrzykowski AZ, Ortiz-Miranda S, Knott TK, Custer E, Puig S, Lemos JR, Treistman SN. Molecular tolerance of voltage-gated calcium channels is evident after short exposures to alcohol in vasopressin-releasing nerve terminals. Alcohol Clin Exp Res. 2013 Jun; 37(6):933-40.

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Larocca TJ, Jeong D, Kohlbrenner E, Lee A, Chen J, Hajjar RJ, Tarzami ST. CXCR4 gene transfer prevents pressure overload induced heart failure. J Mol Cell Cardiol. 2012 Aug; 53(2):223-32.

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Lemos JR, Ortiz-Miranda SI, Cuadra AE, Vel?zquez-Marrero C, Custer EE, Dad T, Dayanithi G. Modulation/physiology of calcium channel sub-types in neurosecretory terminals. Cell Calcium. 2012 Mar-Apr; 51(3-4):284-92.

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Alvin Z, Laurence GG, Coleman BR, Zhao A, Hajj-Moussa M, Haddad GE. Regulation of L-type inward calcium channel activity by captopril and angiotensin II via the phosphatidyl inositol 3-kinase pathway in cardiomyocytes from volume-overload hypertrophied rat hearts. Can J Physiol Pharmacol. 2011 Mar; 89(3):206-15.

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Lv P, Rodriguez-Contreras A, Kim HJ, Zhu J, Wei D, Choong-Ryoul S, Eastwood E, Mu K, Levic S, Song H, Yevgeniy PY, Smith PJ, Yamoah EN. Release and elementary mechanisms of nitric oxide in hair cells. J Neurophysiol. 2010 May; 103(5):2494-505.

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