"Smad7 Protein" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
An inhibitory smad protein that associates with TRANSFORMING GROWTH FACTOR BETA RECEPTORS and BONE MORPHOGENETIC PROTEIN RECEPTORS. It negatively regulates SIGNAL TRANSDUCTION PATHWAYS by inhibiting PHOSPHORYLATION of RECEPTOR-REGULATED SMAD PROTEINS.
| Descriptor ID |
D051906
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| MeSH Number(s) |
D12.644.360.024.334.200.700 D12.776.157.057.170.249.700 D12.776.476.024.428.249.700
|
| Concept/Terms |
|
Below are MeSH descriptors whose meaning is more general than "Smad7 Protein".
Below are MeSH descriptors whose meaning is more specific than "Smad7 Protein".
This graph shows the total number of publications written about "Smad7 Protein" by people in this website by year, and whether "Smad7 Protein" was a major or minor topic of these publications.
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| Year | Major Topic | Minor Topic | Total |
|---|
| 2011 | 1 | 0 | 1 |
| 2014 | 0 | 1 | 1 |
| 2018 | 0 | 1 | 1 |
| 2021 | 1 | 0 | 1 |
| 2022 | 1 | 0 | 1 |
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Below are the most recent publications written about "Smad7 Protein" by people in Profiles.
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Kong X, Yan K, Deng P, Fu H, Sun H, Huang W, Jiang S, Dai J, Zhang QC, Liu JG, Xi Q. LncRNA-Smad7 mediates cross-talk between Nodal/TGF-? and BMP signaling to regulate cell fate determination of pluripotent and multipotent cells. Nucleic Acids Res. 2022 10 14; 50(18):10526-10543.
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Kaushal JB, Shukla V, Sankhwar P, Jha RK, Dwivedi A. Targeted inhibition of TAK1 abrogates TGF?1 non-canonical signaling axis, NF?B/Smad7 inhibiting human endometriotic cells proliferation and inducing cell death involving autophagy. Cytokine. 2021 12; 148:155700.
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Cologne J, Loo L, Shvetsov YB, Misumi M, Lin P, Haiman CA, Wilkens LR, Le Marchand L. Stepwise approach to SNP-set analysis illustrated with the Metabochip and colorectal cancer in Japanese Americans of the Multiethnic Cohort. BMC Genomics. 2018 Jul 09; 19(1):524.
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Kupfer SS, Skol AD, Hong E, Ludvik A, Kittles RA, Keku TO, Sandler RS, Ellis NA. Shared and independent colorectal cancer risk alleles in TGF?-related genes in African and European Americans. Carcinogenesis. 2014 Sep; 35(9):2025-30.
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Zhao Y, Thornton AM, Kinney MC, Ma CA, Spinner JJ, Fuss IJ, Shevach EM, Jain A. The deubiquitinase CYLD targets Smad7 protein to regulate transforming growth factor ? (TGF-?) signaling and the development of regulatory T cells. J Biol Chem. 2011 Nov 25; 286(47):40520-30.