"Sp3 Transcription Factor" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
A specificity protein transcription factor that contains three C-terminal CYS2-HIS2 ZINC FINGERS. It regulates expression of a variety of genes including VASCULAR ENDOTHELIAL GROWTH FACTOR and CYCLIN-DEPENDENT KINASE INHIBITOR P27.
| Descriptor ID |
D051705
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| MeSH Number(s) |
D12.776.260.522.750.750 D12.776.930.375.750.750
|
| Concept/Terms |
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Below are MeSH descriptors whose meaning is more general than "Sp3 Transcription Factor".
Below are MeSH descriptors whose meaning is more specific than "Sp3 Transcription Factor".
This graph shows the total number of publications written about "Sp3 Transcription Factor" by people in this website by year, and whether "Sp3 Transcription Factor" was a major or minor topic of these publications.
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| Year | Major Topic | Minor Topic | Total |
|---|
| 2002 | 0 | 1 | 1 |
| 2003 | 0 | 1 | 1 |
| 2004 | 0 | 1 | 1 |
| 2008 | 2 | 0 | 2 |
| 2013 | 1 | 0 | 1 |
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Below are the most recent publications written about "Sp3 Transcription Factor" by people in Profiles.
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Hoffmann C, Zimmermann A, Hinney A, Volckmar AL, Jarrett HW, Fromme T, Klingenspor M. A novel SP1/SP3 dependent intronic enhancer governing transcription of the UCP3 gene in brown adipocytes. PLoS One. 2013; 8(12):e83426.
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Chen X, Yang J, Sung DY, Thompson W, Walker W, Thomas K. Molecular and functional characterization of the murine ldh2 promoter region: Sp-binding GC-box domains are the key cis-elements regulating ldh2 gene expression during spermatogenesis. Mol Cell Endocrinol. 2008 Nov 25; 295(1-2):10-7.
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Kanemaru KK, Tuthill MC, Takeuchi KK, Sidell N, Wada RK. Retinoic acid induced downregulation of MYCN is not mediated through changes in Sp1/Sp3. Pediatr Blood Cancer. 2008 Apr; 50(4):806-11.
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Miki N, Ikuta M, Matsui T. Hypoxia-induced activation of the retinoic acid receptor-related orphan receptor alpha4 gene by an interaction between hypoxia-inducible factor-1 and Sp1. J Biol Chem. 2004 Apr 09; 279(15):15025-31.
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Tuthill MC, Wada RK, Arimoto JM, Sugino CN, Kanemaru KK, Takeuchi KK, Sidell N. N-myc oncogene expression in neuroblastoma is driven by Sp1 and Sp3. Mol Genet Metab. 2003 Sep-Oct; 80(1-2):272-80.
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Arinze IJ, Kawai Y. Sp family of transcription factors is involved in valproic acid-induced expression of Galphai2. J Biol Chem. 2003 May 16; 278(20):17785-91.
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Miranda GA, Villalvazo M, Galic Z, Alva J, Abrines R, Yates Y, Evans CJ, Aguilera RJ. Combinatorial regulation of the murine RAG-2 promoter by Sp1 and distinct lymphocyte-specific transcription factors. Mol Immunol. 2002 Jun; 38(15):1151-9.