Pituitary Adenylate Cyclase-Activating Polypeptide

"Pituitary Adenylate Cyclase-Activating Polypeptide" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus, MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure, which enables searching at various levels of specificity.

MeSH information

Definition | Details | More General Concepts | Related Concepts | More Specific Concepts

A multi-function neuropeptide that acts throughout the body by elevating intracellular cyclic AMP level via its interaction with PACAP RECEPTORS. Although first isolated from hypothalamic extracts and named for its action on the pituitary, it is widely distributed in the central and peripheral nervous systems. PACAP is important in the control of endocrine and homeostatic processes, such as secretion of pituitary and gut hormones and food intake.

Descriptor ID	D051219
MeSH Number(s)	D12.644.276.860.887 D12.644.400.625 D12.776.467.860.887 D12.776.631.600.887 D12.776.631.650.625 D23.529.850.887
Concept/Terms	Pituitary Adenylate Cyclase-Activating Polypeptide Pituitary Adenylate Cyclase-Activating Polypeptide PACAP Pituitary Adenylate Cyclase Activating Polypeptide Pituitary Adenylate Cyclase Activating Polypeptide 38 Pituitary Adenylate Cyclase Activating Polypeptide 38 PACAP-38 PACAP38 Pituitary Adenylate Cyclase Activating Polypeptide 27 Pituitary Adenylate Cyclase Activating Polypeptide 27 PACAP-27 PACAP27

Below are MeSH descriptors whose meaning is more general than "Pituitary Adenylate Cyclase-Activating Polypeptide".

Chemicals and Drugs [D]
Amino Acids, Peptides, and Proteins [D12]
Peptides [D12.644]
Intercellular Signaling Peptides and Proteins [D12.644.276]
Nerve Growth Factors [D12.644.276.860]
Pituitary Adenylate Cyclase-Activating Polypeptide [D12.644.276.860.887]
Neuropeptides [D12.644.400]
Pituitary Adenylate Cyclase-Activating Polypeptide [D12.644.400.625]
Proteins [D12.776]
Intercellular Signaling Peptides and Proteins [D12.776.467]
Nerve Growth Factors [D12.776.467.860]
Pituitary Adenylate Cyclase-Activating Polypeptide [D12.776.467.860.887]
Nerve Tissue Proteins [D12.776.631]
Nerve Growth Factors [D12.776.631.600]
Pituitary Adenylate Cyclase-Activating Polypeptide [D12.776.631.600.887]
Neuropeptides [D12.776.631.650]
Pituitary Adenylate Cyclase-Activating Polypeptide [D12.776.631.650.625]
Biological Factors [D23]
Intercellular Signaling Peptides and Proteins [D23.529]
Nerve Growth Factors [D23.529.850]
Pituitary Adenylate Cyclase-Activating Polypeptide [D23.529.850.887]

Below are MeSH descriptors whose meaning is related to "Pituitary Adenylate Cyclase-Activating Polypeptide".

Below are MeSH descriptors whose meaning is more specific than "Pituitary Adenylate Cyclase-Activating Polypeptide".

publications

Timeline | Most Recent

This graph shows the total number of publications written about "Pituitary Adenylate Cyclase-Activating Polypeptide" by people in this website by year, and whether "Pituitary Adenylate Cyclase-Activating Polypeptide" was a major or minor topic of these publications.

Bar chart showing 13 publications over 9 distinct years, with a maximum of 4 publications in 2019

To see the data from this visualization as text, click here.

Year	Major Topic	Minor Topic	Total
2004	0	1	1
2009	1	0	1
2012	0	1	1
2013	0	1	1
2014	1	0	1
2017	1	0	1
2019	3	1	4
2020	2	0	2
2021	1	0	1

Below are the most recent publications written about "Pituitary Adenylate Cyclase-Activating Polypeptide" by people in Profiles.

Fang Y, Shi H, Huang L, Ren R, Lenahan C, Xiao J, Liu Y, Liu R, Sanghavi R, Li C, Chen S, Tang J, Yu J, Zhang JH, Zhang J. Pituitary adenylate cyclase-activating polypeptide attenuates mitochondria-mediated oxidative stress and neuronal apoptosis after subarachnoid hemorrhage in rats. Free Radic Biol Med. 2021 10; 174:236-248.

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Nega S, Marquez P, Hamid A, Ahmad SM, Lutfy K. The role of pituitary adenylyl cyclase activating polypeptide in affective signs of nicotine withdrawal. J Neurosci Res. 2020 08; 98(8):1549-1560.

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Stojakovic A, Ahmad SM, Malhotra S, Afzal Z, Ahmed M, Lutfy K. The role of pituitary adenylyl cyclase-activating polypeptide in the motivational effects of addictive drugs. Neuropharmacology. 2020 07; 171:108109.

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Avila JA, Kiprowska M, Jean-Louis T, Rockwell P, Figueiredo-Pereira ME, Serrano PA. PACAP27 mitigates an age-dependent hippocampal vulnerability to PGJ2-induced spatial learning deficits and neuroinflammation in mice. Brain Behav. 2020 01; 10(1):e01465.

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Lutfy K, Shankar G. Emerging evidence for the role of pituitary adenylate cyclase-activating peptide in neuropsychiatric disorders. Prog Mol Biol Transl Sci. 2019; 167:143-157.

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Tseng A, Singh P, Marquez P, Hamid A, Lutfy K. The role of endogenous pituitary adenylyl cyclase activating polypeptide (PACAP) in nicotine self-administration, reward and aversion. Pharmacol Biochem Behav. 2019 06; 181:46-52.

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Wang H, Cheung F, Stoll AC, Rockwell P, Figueiredo-Pereira ME. Mitochondrial and calcium perturbations in rat CNS neurons induce calpain-cleavage of Parkin: Phosphatase inhibition stabilizes pSer65Parkin reducing its calpain-cleavage. Biochim Biophys Acta Mol Basis Dis. 2019 06 01; 1865(6):1436-1450.

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Manavalan S, Getachew B, Manaye KF, Khundmiri SJ, Csoka AB, McKinley R, Tamas A, Reglodi D, Tizabi Y. PACAP Protects Against Ethanol and Nicotine Toxicity in SH-SY5Y Cells: Implications for Drinking-Smoking Co-morbidity. Neurotox Res. 2017 Jul; 32(1):8-13.

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Shivers KY, Nikolopoulou A, Machlovi SI, Vallabhajosula S, Figueiredo-Pereira ME. PACAP27 prevents Parkinson-like neuronal loss and motor deficits but not microglia activation induced by prostaglandin J2. Biochim Biophys Acta. 2014 Sep; 1842(9):1707-19.

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Huang H, Wang H, Figueiredo-Pereira ME. Regulating the ubiquitin/proteasome pathway via cAMP-signaling: neuroprotective potential. Cell Biochem Biophys. 2013 Sep; 67(1):55-66.

View in: PubMed

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