Neutrophil Activation

"Neutrophil Activation" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus, MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure, which enables searching at various levels of specificity.

MeSH information

Definition | Details | More General Concepts | Related Concepts | More Specific Concepts

The process in which the neutrophil is stimulated by diverse substances, resulting in degranulation and/or generation of reactive oxygen products, and culminating in the destruction of invading pathogens. The stimulatory substances, including opsonized particles, immune complexes, and chemotactic factors, bind to specific cell-surface receptors on the neutrophil.

Descriptor ID	D018375
MeSH Number(s)	G12.604
Concept/Terms	Neutrophil Activation Neutrophil Activation Activation, Neutrophil Activations, Neutrophil Neutrophil Activations

Below are MeSH descriptors whose meaning is more general than "Neutrophil Activation".

Biological Sciences [G]
Immune System Phenomena [G12]
Neutrophil Activation [G12.604]

Below are MeSH descriptors whose meaning is more specific than "Neutrophil Activation".

publications

Timeline | Most Recent

This graph shows the total number of publications written about "Neutrophil Activation" by people in this website by year, and whether "Neutrophil Activation" was a major or minor topic of these publications.

Bar chart showing 8 publications over 5 distinct years, with a maximum of 3 publications in 2025

To see the data from this visualization as text, click here.

Year	Major Topic	Minor Topic	Total
2002	0	1	1
2004	0	1	1
2012	0	2	2
2024	1	0	1
2025	2	1	3

Below are the most recent publications written about "Neutrophil Activation" by people in Profiles.

Subia NT, Awamura TK, Dean LS, Loftis K, Gangcuangco LM, MacPherson I, Chang S, Chow DC, Shikuma CM, Park J. Dysregulation of complement components associated with inflammation and coagulation in virally suppressed people living with HIV. J Immunol. 2025 Nov 01; 214(11):2871-2880.

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Lee HJ, Lee NK, Kim J, Kim J, Seo D, Shin HE, Kim J, Ahn JH, Kim SN, Kim HS, Park J, Park W, Hong KS, Park CG, Lee W. Sequential nanoparticle therapy targeting neutrophil hyperactivation to prevent neutrophil-induced pulmonary fibrosis. J Nanobiotechnology. 2025 May 26; 23(1):381.

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Caro-Rivera LM, Malavez-Cajigas S, Lacourt-Ventura M, Rivera-Torres AP, Marcano-Jim?nez DE, L?pez-Colon P, Mu?iz-Hern?ndez J, Rivera-Jim?nez E, Egozcue-Dionisi M, Rom?n-Carlo R, De Jes?s-Rojas W, Ramos-Ben?tez MJ. Age-related neutrophil activation in Hermansky-Pudlak Syndrome Type-1. Orphanet J Rare Dis. 2025 May 12; 20(1):226.

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Warner S, Teague HL, Ramos-Benitez MJ, Panicker S, Allen K, Gairhe S, Moyer T, Parachalil Gopalan B, Douagi I, Shet A, Kanthi Y, Suffredini AF, Chertow DS, Strich JR. R406 reduces lipopolysaccharide-induced neutrophil activation. Cell Immunol. 2024 Sep-Oct; 403-404:104860.

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Kim K, Li J, Barazia A, Tseng A, Youn SW, Abbadessa G, Yu Y, Schwartz B, Andrews RK, Gordeuk VR, Cho J. ARQ 092, an orally-available, selective AKT inhibitor, attenuates neutrophil-platelet interactions in sickle cell disease. Haematologica. 2017 02; 102(2):246-259.

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Ooi JD, Chang J, Hickey MJ, Borza DB, Fugger L, Holdsworth SR, Kitching AR. The immunodominant myeloperoxidase T-cell epitope induces local cell-mediated injury in antimyeloperoxidase glomerulonephritis. Proc Natl Acad Sci U S A. 2012 Sep 25; 109(39):E2615-24.

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Bezerra Bde B, Andriankaja O, Kang J, Pacios S, Bae HJ, Li Y, Tsiagbe V, Schreiner H, Fine DH, Graves DT. A.actinomycetemcomitans-induced periodontal disease promotes systemic and local responses in rat periodontium. J Clin Periodontol. 2012 Apr; 39(4):333-41.

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Pearl JM, Schwartz SM, Nelson DP, Wagner CJ, Lyons JM, Bauer SM, Duffy JY. Preoperative glucocorticoids decrease pulmonary hypertension in piglets after cardiopulmonary bypass and circulatory arrest. Ann Thorac Surg. 2004 Mar; 77(3):994-1000.

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Yoshida S, Kobayashi T, Matsuoka H, Seki C, Gosnell WL, Chang SP, Ishii A. T-cell activation and cytokine production via a bispecific single-chain antibody fragment targeted to blood-stage malaria parasites. Blood. 2003 Mar 15; 101(6):2300-6.

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