"4-Butyrolactone" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
One of the FURANS with a carbonyl thereby forming a cyclic lactone. It is an endogenous compound made from gamma-aminobutyrate and is the precursor of gamma-hydroxybutyrate. It is also used as a pharmacological agent and solvent.
| Descriptor ID |
D015107
|
| MeSH Number(s) |
D02.540.150 D03.383.312.150
|
| Concept/Terms |
4-Butyrolactone- 4-Butyrolactone
- 4 Butyrolactone
- Dihydro-2(3H)-furanone
- gamma-Butyrolactone
- gamma Butyrolactone
- Furanone, tetrahydro-2-
- Furanone, tetrahydro 2
- 1,4-Butanolide
- 1,4 Butanolide
- 4-Hydroxybutyric Acid Lactone
- 4 Hydroxybutyric Acid Lactone
- Lactone, 4-Hydroxybutyric Acid
|
Below are MeSH descriptors whose meaning is more general than "4-Butyrolactone".
Below are MeSH descriptors whose meaning is more specific than "4-Butyrolactone".
This graph shows the total number of publications written about "4-Butyrolactone" by people in this website by year, and whether "4-Butyrolactone" was a major or minor topic of these publications.
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click here.
| Year | Major Topic | Minor Topic | Total |
|---|
| 2002 | 1 | 0 | 1 |
| 2009 | 0 | 1 | 1 |
| 2013 | 1 | 0 | 1 |
| 2014 | 1 | 0 | 1 |
| 2015 | 2 | 1 | 3 |
| 2016 | 1 | 0 | 1 |
| 2021 | 1 | 1 | 2 |
| 2022 | 0 | 2 | 2 |
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Below are the most recent publications written about "4-Butyrolactone" by people in Profiles.
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Gonzalez Periche P, Ramdular A, Bhupathiraju NVSDK, Kalidindi T, Johnson DS, Pillarsetty N, Mootoo DR. Synthesis of carbohydrate analogues of the THF-acetogenin 4-deoxyannomontacin and their cytotoxicity against human prostate cancer cell lines. Carbohydr Res. 2022 Nov; 521:108671.
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Rana S, Kour S, Kizhake S, King HM, Mallareddy JR, Case AJ, Huxford T, Natarajan A. Dimers of isatin derived a-methylene-?-butyrolactone as potent anti-cancer agents. Bioorg Med Chem Lett. 2022 06 01; 65:128713.
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Osinaga FO, Blakeslee K, Kharel MK, Waguespack Y, Victor Hsia S. Method validation of gamma-Hydroxybutyric acid detection upon Herpes Simplex Virus-Type 1 infection using LC-MRM-MS with 3-nitrophenylhydrazine derivatization. J Pharm Biomed Anal. 2022 Feb 20; 210:114547.
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Liu G, Li J, Li Y, Hu Y, Franke AA, Liang L, Hu FB, Chan AT, Mukamal KJ, Rimm EB, Sun Q. Gut microbiota-derived metabolites and risk of coronary artery disease: a prospective study among US men and women. Am J Clin Nutr. 2021 07 01; 114(1):238-247.
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Rochford K, Chen F, Waguespack Y, Figliozzi RW, Kharel MK, Zhang Q, Martin-Caraballo M, Hsia SV. Volatile Organic Compound Gamma-Butyrolactone Released upon Herpes Simplex Virus Type -1 Acute Infection Modulated Membrane Potential and Repressed Viral Infection in Human Neuron-Like Cells. PLoS One. 2016; 11(8):e0161119.
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Hu Y, Song Y, Franke AA, Hu FB, van Dam RM, Sun Q. A Prospective Investigation of the Association Between Urinary Excretion of Dietary Lignan Metabolites and Weight Change in US Women. Am J Epidemiol. 2015 Sep 15; 182(6):503-11.
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Zhou Z, Walleser PM, Tius MA. Isotetronic acids from an oxidative cyclization. Chem Commun (Camb). 2015 Jul 11; 51(54):10858-60.
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Miller CM, Benneche T, Tius MA. First total synthesis of the marine natural products clavulolactones II and III. Org Biomol Chem. 2015 Apr 07; 13(13):4051-8.
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Sun Q, Wedick NM, Pan A, Townsend MK, Cassidy A, Franke AA, Rimm EB, Hu FB, van Dam RM. Gut microbiota metabolites of dietary lignans and risk of type 2 diabetes: a prospective investigation in two cohorts of U.S. women. Diabetes Care. 2014; 37(5):1287-95.
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Chorna NE, Santos-Soto IJ, Carballeira NM, Morales JL, de la Nuez J, C?tala-Valentin A, Chornyy AP, V?zquez-Montes A, De Ortiz SP. Fatty acid synthase as a factor required for exercise-induced cognitive enhancement and dentate gyrus cellular proliferation. PLoS One. 2013; 8(11):e77845.