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David Mootoo

TitleProfessor of Chemistry
InstitutionHunter College, CUNY
Departmentchemistry
AddressRoom 1307 HN, Hunter College, CUNY
695 Park Avenue
New York NY 10065
Phone(212) 772-4356
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    R01GM057865     (MOOTOO, DAVID R.)Mar 1, 1999 - May 31, 2009
    NIH
    Synthesis of Glycomimetics and Related Structures
    Role: Principal Investigator

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    Collapse selected publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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    PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. Periche PG, Lin J, Bhupathiraju NVSDK, Kalidindi T, Johnson DS, Pillarsetty N, Mootoo DR. Targeting Carbohydrate Mimetics of Tetrahydrofuran-Containing Acetogenins to Prostate Cancer. Molecules. 2023 Mar 23; 28(7). PMID: 37049648.
      Citations:    Fields:    Translation:HumansCells
    2. Barchi JJ, De Meo C, Mootoo DR. Editorial: Tribute to Professor Bert Fraser-Reid. Carbohydr Res. 2023 04; 526:108795. PMID: 37002031.
      Citations:    Fields:    
    3. Gonzalez Periche P, Ramdular A, Bhupathiraju NVSDK, Kalidindi T, Johnson DS, Pillarsetty N, Mootoo DR. Synthesis of carbohydrate analogues of the THF-acetogenin 4-deoxyannomontacin and their cytotoxicity against human prostate cancer cell lines. Carbohydr Res. 2022 Nov; 521:108671. PMID: 36113243.
      Citations: 1     Fields:    Translation:HumansCells
    4. Hans SK, Truong S, Mootoo DR. Oxocarbenium ion cyclizations for the synthesis of disaccharide mimetics of 2-amino-2-deoxy-pyranosides: Application to the carbasugar of ?-galactosamine-(1,4)-3-O-methyl-D-chiro-inositol. Carbohydr Res. 2022 Aug; 518:108595. PMID: 35643049.
      Citations:    Fields:    Translation:Cells
    5. Truong S, Mootoo DR. C-Glycosylcrotylboronates for the Synthesis of Glycomimetics. Org Lett. 2022 01 14; 24(1):191-195. PMID: 34958591.
      Citations:    Fields:    
    6. Valles DJ, Zholdassov YS, Korpanty J, Uddin S, Naeem Y, Mootoo DR, Gianneschi NC, Braunschweig AB. Glycopolymer Microarrays with Sub-Femtomolar Avidity for Glycan Binding Proteins Prepared by Grafted-To/Grafted-From Photopolymerizations. Angew Chem Int Ed Engl. 2021 09 06; 60(37):20350-20357. PMID: 34273126.
      Citations: 1     Fields:    
    7. Valles DJ, Naeem Y, Rozenfeld AY, Aldasooky RW, Wong AM, Carbonell C, Mootoo DR, Braunschweig AB. Multivalent binding of concanavalin A on variable-density mannoside microarrays. Faraday Discuss. 2019 10 30; 219(0):77-89. PMID: 31364656.
      Citations: 3     Fields:    Translation:Cells
    8. Valles DJ, Naeem Y, Carbonell C, Wong AM, Mootoo DR, Braunschweig AB. Maskless Photochemical Printing of Multiplexed Glycan Microarrays for High-Throughput Binding Studies. ACS Biomater Sci Eng. 2019 Jun 10; 5(6):3131-3138. PMID: 33405545.
      Citations: 2     Fields:    
    9. Ban Y, Dong W, Zhang L, Zhou T, Altiti AS, Ali K, Mootoo DR, Blaho VA, Hla T, Ren Y, Ma X. Abrogation of Endogenous Glycolipid Antigen Presentation on Myelin-Laden Macrophages by D-Sphingosine Ameliorates the Pathogenesis of Experimental Autoimmune Encephalomyelitis. Front Immunol. 2019; 10:404. PMID: 30941120.
      Citations: 1     Fields:    Translation:AnimalsCells
    10. Altiti AS, Mootoo DR. Synthesis of C-Glycoinositols from C-Glycosylcrotylstannanes. J Org Chem. 2018 06 15; 83(12):6534-6540. PMID: 29786442.
      Citations:    Fields:    
    11. Altiti AS, Ma X, Zhang L, Ban Y, Franck RW, Mootoo DR. Synthesis and biological activities of C-glycosides of KRN 7000 with novel ceramide residues. Carbohydr Res. 2017 Apr 18; 443-444:73-77. PMID: 28365448.
      Citations: 1     Fields:    Translation:Animals
    12. Altiti AS, Bachan S, Mootoo DR. The Crotylation Way to Glycosphingolipids: Synthesis of Analogues of KRN7000. Org Lett. 2016 09 16; 18(18):4654-7. PMID: 27560147.
      Citations: 4     Fields:    Translation:Cells
    13. Mattis CE, Mootoo DR. A ring closing metathesis strategy for carbapyranosides of xylose and arabinose. Carbohydr Res. 2016 Jun 24; 429:143-7. PMID: 27236269.
      Citations:    Fields:    Translation:Cells
    14. Mattis CE, Mootoo DR. A ring closing metathesis strategy for carbapyranosides of xylose and arabinose. Carbohydr Res. 2016 Apr 29; 425:43-7. PMID: 27035910.
      Citations:    Fields:    Translation:Cells
    15. Altiti AS, Bachan S, Alrowhani W, Mootoo DR. An organocatalytic strategy for the stereoselective synthesis of C-galactosides with fluorine at the pseudoanomeric carbon. Org Biomol Chem. 2015 Nov 07; 13(41):10328-35. PMID: 26312438.
      Citations: 1     Fields:    Translation:Cells
    16. Altiti AS, Mootoo DR. C-glycosphingolipid precursors via iodocyclization of homoallyic trichloroacetimidates. Carbohydr Res. 2015 Apr 30; 407:148-53. PMID: 25771297.
      Citations:    Fields:    Translation:Cells
    17. Altiti AS, Mootoo DR. Intramolecular nitrogen delivery for the synthesis of C-glycosphingolipids. Application to the C-glycoside of the immunostimulant KRN7000. Org Lett. 2014 Mar 07; 16(5):1466-9. PMID: 24559301.
      Citations: 5     Fields:    Translation:Cells
    18. Hans S, Altiti A, Mootoo DR. Synthesis of the C-glycoside of a-(D)-mannose-(1 ? 6)-(D)-myo-inositol. Org Biomol Chem. 2013 Sep 25; 11(40):6952-9. PMID: 24057020.
      Citations:    Fields:    Translation:Cells
    19. Bachan S, Tony KA, Kawamura A, Montenegro D, Joshi A, Garg H, Mootoo DR. Synthesis and anti-tumor activity of carbohydrate analogues of the tetrahydrofuran containing acetogenins. Bioorg Med Chem. 2013 Nov 01; 21(21):6554-64. PMID: 24045006.
      Citations: 2     Fields:    Translation:HumansCells
    20. Li J, Todaro L, Mootoo DR. Synthesis of an A'B' Precursor to Angelmicin B: Product Diversification in the Su?rez Lactol Fragmentation. European J Org Chem. 2011 Nov 01; 2011(31):6281-6287. PMID: 22745567.
      Citations:    
    21. Bachan S, Fantini J, Joshi A, Garg H, Mootoo DR. Synthesis, gp120 binding and anti-HIV activity of fatty acid esters of 1,1-linked disaccharides. Bioorg Med Chem. 2011 Aug 15; 19(16):4803-11. PMID: 21783371.
      Citations: 2     Fields:    Translation:HumansCells
    22. Hans SK, Camara F, Altiti A, Mart?n-Montalvo A, Brautigan DL, Heimark D, Larner J, Grindrod S, Brown ML, Mootoo DR. Synthesis of C-glycoside analogues of beta-galactosamine-(1-->4)-3-O-methyl-D-chiro-inositol and assay as activator of protein phosphatases PDHP and PP2Calpha. Bioorg Med Chem. 2010 Feb; 18(3):1103-10. PMID: 20079654.
      Citations: 6     Fields:    Translation:AnimalsCells
    23. Tony KA, Dabideen D, Li J, D?az-Hern?ndez MD, Jim?nez-Barbero J, Mootoo DR. Olefin metathesis-iodoetherification-dehydroiodination strategy for spiroketal subunits of polyether antibiotics. J Org Chem. 2009 Oct 16; 74(20):7774-80. PMID: 19813766.
      Citations:    Fields:    Translation:Cells
    24. Li J, Li X, Mootoo DR. Synthetic and Computational Studies on the ABC Trioxadispiroketal Subunit of the Marine Biotoxin Azaspiracid-1. Nat Prod Commun. 2008 Nov; 3(11):1771-1780. PMID: 19759853.
      Citations:    Fields:    
    25. Parhi AK, Mootoo DR, Franck RW. Synthesis of the Mixed Acetal Segment of S-Glyceroplasmalopsychosine. Tetrahedron. 2008 Oct 13; 64(42):9821-9827. PMID: 19829689.
      Citations: 1     Fields:    
    26. Wang F, Kawamura A, Mootoo DR. Synthesis and antitumor activity of C-9 epimers of the tetrahydrofuran containing acetogenin 4-deoxyannoreticuin. Bioorg Med Chem. 2008 Sep 15; 16(18):8413-8. PMID: 18774299.
      Citations: 4     Fields:    Translation:HumansCells
    27. Garg H, Francella N, Tony KA, Augustine LA, Barchi JJ, Fantini J, Puri A, Mootoo DR, Blumenthal R. Glycoside analogs of beta-galactosylceramide, a novel class of small molecule antiviral agents that inhibit HIV-1 entry. Antiviral Res. 2008 Oct; 80(1):54-61. PMID: 18538869.
      Citations: 8     Fields:    Translation:HumansCells
    28. Li J, Todaro LJ, Mootoo DR. Synthesis of the AB subunit of angelmicin B through a tandem alkoxy radical fragmentation-etherification sequence. Org Lett. 2008 Apr 03; 10(7):1337-40. PMID: 18324819.
      Citations: 6     Fields:    Translation:Cells
    29. Tony KA, Li X, Dabideen D, Li J, Mootoo DR. An iodoetherification-dehydroiodination strategy for the synthesis of complex spiroketals from dihydroxyalkene precursors. Org Biomol Chem. 2008 Apr 07; 6(7):1165-9. PMID: 18362952.
      Citations: 1     Fields:    Translation:Cells
    30. Li X, Li J, Mootoo DR. Synthesis of the ABCD trioxadispiroketal subunit of azaspiracid-1: an iodoetherification-dehydroiodination strategy for complex spiroketals. Org Lett. 2007 Oct 11; 9(21):4303-6. PMID: 17880232.
      Citations: 5     Fields:    Translation:Cells
    31. Denton RW, Tony KA, Hern?ndez-Gay JJ, Ca?ada FJ, Jim?nez-Barbero J, Mootoo DR. Synthesis and conformational behavior of the difluoromethylene linked C-glycoside analog of beta-galactopyranosyl-(1<-->1)-alpha-mannopyranoside. Carbohydr Res. 2007 Sep 03; 342(12-13):1624-35. PMID: 17601514.
      Citations: 4     Fields:    Translation:Cells
    32. Tony KA, Denton RW, Dilhas A, Jim?nez-Barbero J, Mootoo DR. Synthesis of beta-C-galacto-pyranosides with fluorine on the pseudoanomeric substituent. Org Lett. 2007 Apr 12; 9(8):1441-4. PMID: 17358072.
      Citations: 5     Fields:    Translation:Cells
    33. P?rez-Castells J, Hern?ndez-Gay JJ, Denton RW, Tony KA, Mootoo DR, Jim?nez-Barbero J. The conformational behaviour and P-selectin inhibition of fluorine-containing sialyl LeX glycomimetics. Org Biomol Chem. 2007 Apr 07; 5(7):1087-92. PMID: 17377662.
      Citations: 6     Fields:    Translation:HumansCells
    34. Hans S, Mootoo DR. A de novo approach to C-branched inositols: synthesis of a myo-inositol precursor for C-linked glycosyl phosphatidylinositols. Carbohydr Res. 2006 Jul 24; 341(10):1322-32. PMID: 16698000.
      Citations:    Fields:    Translation:Cells
    35. Augustin LA, Fantini J, Mootoo DR. C-Glycoside analogues of beta-galactosylceramide with a simple ceramide substitute: synthesis and binding to HIV-1 gp120. Bioorg Med Chem. 2006 Feb 15; 14(4):1182-8. PMID: 16216516.
      Citations: 4     Fields:    Translation:Cells
    36. Camara F, Angarita J, Mootoo DR. Oxocarbenium ion cyclizations for C-branched cyclitols: synthesis of a relay intermediate for fumagillin analogues. J Org Chem. 2005 Aug 19; 70(17):6870-5. PMID: 16095307.
      Citations:    Fields:    Translation:Cells
    37. Zhu L, Mootoo DR. Synthesis of the non-classical acetogenin mucocin: a modular approach based on olefinic coupling reactions. Org Biomol Chem. 2005 Aug 07; 3(15):2750-4. PMID: 16032353.
      Citations: 4     Fields:    
    38. Zhu L, Mootoo DR. Total synthesis of the nonadjacently linked bis-tetrahydrofuran acetogenin bullatanocin (squamostatin C). J Org Chem. 2004 Apr 30; 69(9):3154-7. PMID: 15104456.
      Citations: 4     Fields:    Translation:Cells
    39. Zhu L, Mootoo DR. Synthesis of nonadjacently linked tetrahydrofurans: an iodoetherification and olefin metathesis approach. Org Lett. 2003 Sep 18; 5(19):3475-8. PMID: 12967303.
      Citations: 3     Fields:    Translation:Cells
    40. Cheng X, Khan N, Kumaran G, Mootoo DR. A convergent strategy for the synthesis of beta-carba-galacto-disaccharides. Org Lett. 2001 May 03; 3(9):1323-5. PMID: 11348225.
      Citations: 2     Fields:    Translation:Cells
    41. Zhao H, Hans S, Cheng X, Mootoo DR. Allylated monosaccharides as precursors in triple reductive amination strategies: synthesis of castanospermine and swainsonine. J Org Chem. 2001 Mar 09; 66(5):1761-7. PMID: 11262124.
      Citations: 2     Fields:    Translation:Cells
    42. Cheng X, Khan N, Mootoo DR. Synthesis of the C-glycoside analogue of a novel sialyl Lewis X mimetic. J Org Chem. 2000 Apr 21; 65(8):2544-7. PMID: 10789469.
      Citations: 2     Fields:    Translation:Cells
    43. Asensio JL, Ca?ada FJ, Cheng X, Khan N, Mootoo DR, Jim?nez-Barbero J. Conformational differences between O- and C-glycosides: the alpha-O-man-(1-->1)-beta-Gal/alpha-C-Man-(1-->1)-beta-Gal case--a decisive demonstration of the importance of the exo-anomeric effect on the conformation of glycosides. Chemistry. 2000 Mar 17; 6(6):1035-41. PMID: 10785824.
      Citations: 15     Fields:    Translation:Cells
    44. Zhao H, Mootoo DR. Triple Reductive Amination Approach to Polyhydroxyindolizidine Alkaloids: A Total Synthesis of Castanospermine. J Org Chem. 1996 Oct 04; 61(20):6762-6763. PMID: 11667561.
      Citations: 1     Fields:    
    45. Maxwell A, Seepersaud M, Pingal R, Mootoo DR, Reynolds WF. 3 beta-aminospirosolane steroidal alkaloids from Solanum triste. J Nat Prod. 1995 Apr; 58(4):625-8. PMID: 7623041.
      Citations: 3     Fields:    
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