Galactosylceramides

"Galactosylceramides" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus, MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure, which enables searching at various levels of specificity.

MeSH information

Definition | Details | More General Concepts | Related Concepts | More Specific Concepts

Cerebrosides which contain as their polar head group a galactose moiety bound in glycosidic linkage to the hydroxyl group of ceramide. Their accumulation in tissue, due to a defect in beta-galactosidase, is the cause of galactosylceramide lipidosis or globoid cell leukodystrophy.

Descriptor ID	D005699
MeSH Number(s)	D02.065.313.250.450 D09.400.410.420.525.200.250.450 D10.390.470.675.200.250.450 D10.570.877.360.612.200.250.450
Concept/Terms	Galactosylceramides Galactosylceramides Galactosyl Ceramides Ceramides, Galactosyl Galactocerebrosides

Below are MeSH descriptors whose meaning is more general than "Galactosylceramides".

Chemicals and Drugs [D]
Organic Chemicals [D02]
Amides [D02.065]
Ceramides [D02.065.313]
Cerebrosides [D02.065.313.250]
Galactosylceramides [D02.065.313.250.450]
Carbohydrates [D09]
Glycoconjugates [D09.400]
Glycolipids [D09.400.410]
Glycosphingolipids [D09.400.410.420]
Neutral Glycosphingolipids [D09.400.410.420.525]
Ceramides [D09.400.410.420.525.200]
Cerebrosides [D09.400.410.420.525.200.250]
Galactosylceramides [D09.400.410.420.525.200.250.450]
Lipids [D10]
Glycolipids [D10.390]
Glycosphingolipids [D10.390.470]
Neutral Glycosphingolipids [D10.390.470.675]
Ceramides [D10.390.470.675.200]
Cerebrosides [D10.390.470.675.200.250]
Galactosylceramides [D10.390.470.675.200.250.450]
Membrane Lipids [D10.570]
Sphingolipids [D10.570.877]
Glycosphingolipids [D10.570.877.360]
Neutral Glycosphingolipids [D10.570.877.360.612]
Ceramides [D10.570.877.360.612.200]
Cerebrosides [D10.570.877.360.612.200.250]
Galactosylceramides [D10.570.877.360.612.200.250.450]

Below are MeSH descriptors whose meaning is related to "Galactosylceramides".

Below are MeSH descriptors whose meaning is more specific than "Galactosylceramides".

publications

Timeline | Most Recent

This graph shows the total number of publications written about "Galactosylceramides" by people in this website by year, and whether "Galactosylceramides" was a major or minor topic of these publications.

Bar chart showing 12 publications over 9 distinct years, with a maximum of 2 publications in 2008 and 2015 and 2017

To see the data from this visualization as text, click here.

Year	Major Topic	Minor Topic	Total
2005	1	0	1
2008	1	1	2
2011	0	1	1
2014	1	0	1
2015	2	0	2
2016	1	0	1
2017	2	0	2
2019	1	0	1
2021	1	0	1

Below are the most recent publications written about "Galactosylceramides" by people in Profiles.

Shute T, Amiel E, Alam N, Yates JL, Mohrs K, Dudley E, Salas B, Mesa C, Serrata A, Angel D, Vincent BK, Weyers A, Lanthier PA, Vomhof-Dekrey E, Fromme R, Laughlin M, Durham O, Miao J, Shipp D, Linhardt RJ, Nash K, Leadbetter EA. Glycolipid-Containing Nanoparticle Vaccine Engages Invariant NKT Cells to Enhance Humoral Protection against Systemic Bacterial Infection but Abrogates T-Independent Vaccine Responses. J Immunol. 2021 04 15; 206(8):1806-1816.

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Ban Y, Dong W, Zhang L, Zhou T, Altiti AS, Ali K, Mootoo DR, Blaho VA, Hla T, Ren Y, Ma X. Abrogation of Endogenous Glycolipid Antigen Presentation on Myelin-Laden Macrophages by D-Sphingosine Ameliorates the Pathogenesis of Experimental Autoimmune Encephalomyelitis. Front Immunol. 2019; 10:404.

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Li X, Huang J, Kawamura A, Funakoshi R, Porcelli SA, Tsuji M. Co-localization of a CD1d-binding glycolipid with an adenovirus-based malaria vaccine for a potent adjuvant effect. Vaccine. 2017 05 31; 35(24):3171-3177.

View in: PubMed
Altiti AS, Ma X, Zhang L, Ban Y, Franck RW, Mootoo DR. Synthesis and biological activities of C-glycosides of KRN 7000 with novel ceramide residues. Carbohydr Res. 2017 Apr 18; 443-444:73-77.

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Altiti AS, Bachan S, Mootoo DR. The Crotylation Way to Glycosphingolipids: Synthesis of Analogues of KRN7000. Org Lett. 2016 09 16; 18(18):4654-7.

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Li X, Kawamura A, Andrews CD, Miller JL, Wu D, Tsao T, Zhang M, Oren D, Padte NN, Porcelli SA, Wong CH, Kappe SH, Ho DD, Tsuji M. Colocalization of a CD1d-Binding Glycolipid with a Radiation-Attenuated Sporozoite Vaccine in Lymph Node-Resident Dendritic Cells for a Robust Adjuvant Effect. J Immunol. 2015 Sep 15; 195(6):2710-21.

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Altiti AS, Mootoo DR. C-glycosphingolipid precursors via iodocyclization of homoallyic trichloroacetimidates. Carbohydr Res. 2015 Apr 30; 407:148-53.

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Altiti AS, Mootoo DR. Intramolecular nitrogen delivery for the synthesis of C-glycosphingolipids. Application to the C-glycoside of the immunostimulant KRN7000. Org Lett. 2014 Mar 07; 16(5):1466-9.

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Bachan S, Fantini J, Joshi A, Garg H, Mootoo DR. Synthesis, gp120 binding and anti-HIV activity of fatty acid esters of 1,1-linked disaccharides. Bioorg Med Chem. 2011 Aug 15; 19(16):4803-11.

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Chen S, Ndhlovu LC, Takahashi T, Takeda K, Ikarashi Y, Kikuchi T, Murata K, Pandolfi PP, Riccardi C, Ono M, Sugamura K, Ishii N. Co-inhibitory roles for glucocorticoid-induced TNF receptor in CD1d-dependent natural killer T cells. Eur J Immunol. 2008 Aug; 38(8):2229-40.

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