"Picrotoxin" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
A noncompetitive antagonist at GABA-A receptors and thus a convulsant. Picrotoxin blocks the GAMMA-AMINOBUTYRIC ACID-activated chloride ionophore. Although it is most often used as a research tool, it has been used as a CNS stimulant and an antidote in poisoning by CNS depressants, especially the barbiturates.
| Descriptor ID |
D010852
|
| MeSH Number(s) |
D02.455.426.392.368.367.800 D02.540.552
|
| Concept/Terms |
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Below are MeSH descriptors whose meaning is more general than "Picrotoxin".
Below are MeSH descriptors whose meaning is more specific than "Picrotoxin".
This graph shows the total number of publications written about "Picrotoxin" by people in this website by year, and whether "Picrotoxin" was a major or minor topic of these publications.
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| Year | Major Topic | Minor Topic | Total |
|---|
| 1996 | 0 | 1 | 1 |
| 1999 | 0 | 2 | 2 |
| 2001 | 0 | 1 | 1 |
| 2002 | 0 | 1 | 1 |
| 2003 | 0 | 1 | 1 |
| 2010 | 0 | 1 | 1 |
| 2011 | 0 | 1 | 1 |
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Below are the most recent publications written about "Picrotoxin" by people in Profiles.
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Duan B, Wang YZ, Yang T, Chu XP, Yu Y, Huang Y, Cao H, Hansen J, Simon RP, Zhu MX, Xiong ZG, Xu TL. Extracellular spermine exacerbates ischemic neuronal injury through sensitization of ASIC1a channels to extracellular acidosis. J Neurosci. 2011 Feb 09; 31(6):2101-12.
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Lobb CJ, Wilson CJ, Paladini CA. A dynamic role for GABA receptors on the firing pattern of midbrain dopaminergic neurons. J Neurophysiol. 2010 Jul; 104(1):403-13.
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Rosenstein FJ, Chappell RL. Endogenous zinc as a retinal neuromodulator: evidence from the skate (Raja erinacea). Neurosci Lett. 2003 Jul 17; 345(2):81-4.
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Chappell RL, Schuette E, Anton R, Ripps H. GABA(C) receptors modulate the rod-driven ERG b-wave of the skate retina. Doc Ophthalmol. 2002 Sep; 105(2):179-88.
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Cheng Q, Burkat PM, Kulli JC, Yang J. GABA(C) rho(1) subunits form functional receptors but not functional synapses in hippocampal neurons. J Neurophysiol. 2001 Nov; 86(5):2605-15.
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Paladini CA, Tepper JM. GABA(A) and GABA(B) antagonists differentially affect the firing pattern of substantia nigra dopaminergic neurons in vivo. Synapse. 1999 Jun 01; 32(3):165-76.
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Paladini CA, Celada P, Tepper JM. Striatal, pallidal, and pars reticulata evoked inhibition of nigrostriatal dopaminergic neurons is mediated by GABA(A) receptors in vivo. Neuroscience. 1999 Mar; 89(3):799-812.
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Qian H, Malchow RP, Chappell RL, Ripps H. Zinc enhances ionic currents induced in skate M?ller (glial) cells by the inhibitory neurotransmitter GABA. Proc Biol Sci. 1996 Jun 22; 263(1371):791-6.
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Chirwa SS, Sastry BR. Asynchronous synaptic responses in hippocampal CA1 neurons during synaptic long-term potentiation. Neurosci Lett. 1988 Jul 08; 89(3):355-60.
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Sastry BR, Goh JW, May PB, Chirwa SS. The involvement of nonspiking cells in long-term potentiation of synaptic transmission in the hippocampus. Can J Physiol Pharmacol. 1988 Jun; 66(6):841-4.