Serotonin

"Serotonin" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus, MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure, which enables searching at various levels of specificity.

MeSH information

Definition | Details | More General Concepts | Related Concepts | More Specific Concepts

A biochemical messenger and regulator, synthesized from the essential amino acid L-TRYPTOPHAN. In humans it is found primarily in the central nervous system, gastrointestinal tract, and blood platelets. Serotonin mediates several important physiological functions including neurotransmission, gastrointestinal motility, hemostasis, and cardiovascular integrity. Multiple receptor families (RECEPTORS, SEROTONIN) explain the broad physiological actions and distribution of this biochemical mediator.

Descriptor ID	D012701
MeSH Number(s)	D02.092.211.215.801.852 D03.633.100.473.914.814 D23.469.050.650
Concept/Terms	Serotonin Serotonin 5-Hydroxytryptamine 5 Hydroxytryptamine Hippophaine 3-(2-Aminoethyl)-1H-indol-5-ol Enteramine 5-HT Hydroxytryptamine Hydroxytryptamine

Below are MeSH descriptors whose meaning is more general than "Serotonin".

Chemicals and Drugs [D]
Organic Chemicals [D02]
Amines [D02.092]
Biogenic Amines [D02.092.211]
Biogenic Monoamines [D02.092.211.215]
Tryptamines [D02.092.211.215.801]
Serotonin [D02.092.211.215.801.852]
Heterocyclic Compounds [D03]
Heterocyclic Compounds, Fused-Ring [D03.633]
Heterocyclic Compounds, 2-Ring [D03.633.100]
Indoles [D03.633.100.473]
Tryptamines [D03.633.100.473.914]
Serotonin [D03.633.100.473.914.814]
Biological Factors [D23]
Inflammation Mediators [D23.469]
Autacoids [D23.469.050]
Serotonin [D23.469.050.650]

Below are MeSH descriptors whose meaning is related to "Serotonin".

Below are MeSH descriptors whose meaning is more specific than "Serotonin".

Serotonin
5-Methoxytryptamine

publications

Timeline | Most Recent

This graph shows the total number of publications written about "Serotonin" by people in this website by year, and whether "Serotonin" was a major or minor topic of these publications.

Bar chart showing 79 publications over 28 distinct years, with a maximum of 6 publications in 2002 and 2005

To see the data from this visualization as text, click here.

Year	Major Topic	Minor Topic	Total
1996	1	2	3
1997	2	0	2
1998	3	0	3
1999	1	0	1
2000	2	1	3
2001	2	1	3
2002	4	2	6
2003	2	2	4
2004	0	1	1
2005	0	6	6
2006	4	0	4
2007	2	3	5
2008	0	1	1
2009	2	1	3
2010	3	2	5
2011	3	0	3
2012	4	0	4
2013	1	2	3
2014	1	2	3
2015	2	1	3
2016	0	1	1
2018	3	1	4
2019	1	0	1
2020	1	0	1
2021	0	2	2
2022	0	1	1
2024	1	1	2
2025	1	0	1

Below are the most recent publications written about "Serotonin" by people in Profiles.

Kim S, Pajarillo E, Digman A, Ajayi I, Son DS, Aschner M, Lee E. Role of dopaminergic RE1-silencing transcription factor (REST) in manganese-induced behavioral deficits and dysregulating dopaminergic and serotonergic neurotransmission in mice. Neurotoxicology. 2025 May; 108:57-68.

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Hernandez N, Lokhnygina Y, Ramaker ME, Ilkayeva O, Muehlbauer MJ, Crawford ML, Grant RP, Hsia DS, Jain N, Bain JR, Armstrong S, Newgard CB, Freemark M, Gumus Balikcioglu P. Sex Differences in Branched-chain Amino Acid and Tryptophan Metabolism and Pathogenesis of Youth-onset Type 2 Diabetes. J Clin Endocrinol Metab. 2024 Mar 15; 109(4):e1345-e1358.

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Vaasjo LO, Miller MW. A conserved gastropod withdrawal circuit in Biomphalaria glabrata, an intermediate host for schistosomiasis. J Neurophysiol. 2024 05 01; 131(5):903-913.

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Chuang TD, Quintanilla D, Boos D, Khorram O. Further characterization of tryptophan metabolism and its dysregulation in fibroids. F S Sci. 2022 11; 3(4):392-400.

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Banskota S, Brim H, Kwon YH, Singh G, Sinha SR, Wang H, Khan WI, Ashktorab H. Saffron Pre-Treatment Promotes Reduction in Tissue Inflammatory Profiles and Alters Microbiome Composition in Experimental Colitis Mice. Molecules. 2021 Jun 02; 26(11).

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Rom?n M, Garc?a L, Morales M, Crespo MJ. The combination of dantrolene and nimodipine effectively reduces 5-HT-induced vasospasms in diabetic rats. Sci Rep. 2021 05 10; 11(1):9852.

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Pardo-Garc?a TR, Yusif-Rodriguez N, Yudowski G, Maldonado-Vlaar CS. Blockade of the endovanilloid receptor, TRPV1, and of the endocannabinoid enzyme, FAAH, within the nucleus accumbens shell elicits anxiolytic-like effects in male rats. Neurosci Lett. 2020 07 27; 732:135023.

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Wang HL, Zhang S, Qi J, Wang H, Cachope R, Mejias-Aponte CA, Gomez JA, Mateo-Semidey GE, Beaudoin GMJ, Paladini CA, Cheer JF, Morales M. Dorsal Raphe Dual Serotonin-Glutamate Neurons Drive Reward by Establishing Excitatory Synapses on VTA Mesoaccumbens Dopamine Neurons. Cell Rep. 2019 01 29; 26(5):1128-1142.e7.

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Manciu FS, Manciu M, Ciubuc JD, Sundin EM, Ochoa K, Eastman M, Durrer WG, Guerrero J, Lopez B, Subedi M, Bennet KE. Simultaneous Detection of Dopamine and Serotonin-A Comparative Experimental and Theoretical Study of Neurotransmitter Interactions. Biosensors (Basel). 2018 Dec 26; 9(1).

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Niture S, Gyamfi MA, Kedir H, Arthur E, Ressom H, Deep G, Kumar D. Serotonin induced hepatic steatosis is associated with modulation of autophagy and notch signaling pathway. Cell Commun Signal. 2018 11 08; 16(1):78.

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