"Baclofen" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
A GAMMA-AMINOBUTYRIC ACID derivative that is a specific agonist of GABA-B RECEPTORS. It is used in the treatment of MUSCLE SPASTICITY, especially that due to SPINAL CORD INJURIES. Its therapeutic effects result from actions at spinal and supraspinal sites, generally the reduction of excitatory transmission.
| Descriptor ID |
D001418
|
| MeSH Number(s) |
D02.241.081.114.500.350.100
|
| Concept/Terms |
Baclofen- Baclofen
- Baclophen
- PCP-GABA
- beta-(Aminomethyl)-4-chlorobenzenepropanoic Acid
- Chlorophenyl GABA
- GABA, Chlorophenyl
- beta-(p-Chlorophenyl)-gamma-aminobutyric Acid
Ba-34,647- Ba-34,647
- Ba34,647
- Ba-34647
- Ba34647
- CIBA-34,647-BA
- CIBA34,647BA
|
Below are MeSH descriptors whose meaning is more general than "Baclofen".
Below are MeSH descriptors whose meaning is more specific than "Baclofen".
This graph shows the total number of publications written about "Baclofen" by people in this website by year, and whether "Baclofen" was a major or minor topic of these publications.
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| Year | Major Topic | Minor Topic | Total |
|---|
| 1998 | 0 | 1 | 1 |
| 1999 | 0 | 2 | 2 |
| 2004 | 0 | 3 | 3 |
| 2019 | 1 | 0 | 1 |
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Below are the most recent publications written about "Baclofen" by people in Profiles.
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Reynolds K, Kaufman R, Korenoski A, Fennimore L, Shulman J, Lynch M. Trends in gabapentin and baclofen exposures reported to U.S. poison centers. Clin Toxicol (Phila). 2020 07; 58(7):763-772.
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Horn TS, Yablon SA, Chow JW, Lee JE, Stokic DS. Effect of intrathecal baclofen bolus injection on lower extremity joint range of motion during gait in patients with acquired brain injury. Arch Phys Med Rehabil. 2010 Jan; 91(1):30-4.
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D?az-R?os M, Miller MW. Rapid dopaminergic signaling by interneurons that contain markers for catecholamines and GABA in the feeding circuitry of Aplysia. J Neurophysiol. 2005 Apr; 93(4):2142-56.
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Febo M, Segarra AC. Cocaine alters GABA(B)-mediated G-protein activation in the ventral tegmental area of female rats: modulation by estrogen. Synapse. 2004 Oct; 54(1):30-6.
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Porter JT, Nieves D. Presynaptic GABAB receptors modulate thalamic excitation of inhibitory and excitatory neurons in the mouse barrel cortex. J Neurophysiol. 2004 Nov; 92(5):2762-70.
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Paladini CA, Tepper JM. GABA(A) and GABA(B) antagonists differentially affect the firing pattern of substantia nigra dopaminergic neurons in vivo. Synapse. 1999 Jun 01; 32(3):165-76.
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Paladini CA, Celada P, Tepper JM. Striatal, pallidal, and pars reticulata evoked inhibition of nigrostriatal dopaminergic neurons is mediated by GABA(A) receptors in vivo. Neuroscience. 1999 Mar; 89(3):799-812.
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Tepper JM, Paladini CA, Celada P. GABAergic control of the firing pattern of substantia nigra dopaminergic neurons. Adv Pharmacol. 1998; 42:694-9.
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Luine V, Cowell J, Frankfurt M. GABAergic-serotonergic interactions in regulating lordosis. Brain Res. 1991 Aug 09; 556(1):171-4.