Effects of kava alkaloid, pipermethystine, and kavalactones on oxidative stress and cytochrome P450 in F-344 rats.

Lim ST, Dragull K, Tang CS, Bittenbender HC, Efird JT, Nerurkar PV. Effects of kava alkaloid, pipermethystine, and kavalactones on oxidative stress and cytochrome P450 in F-344 rats. Toxicol Sci. 2007 May; 97(1):214-21.

View in: PubMed

subject areas

Alkaloids
Animals
Cytochrome P-450 CYP1A2
Cytochrome P-450 CYP2D6
Cytochrome P-450 CYP2E1
Cytochrome P-450 Enzyme System
Cytochromes
Enzyme Induction
Glutathione
Kava
Lactones
Liver
Male
Mitochondria, Liver
Oxidative Stress
Plant Extracts
Plant Leaves
Pyridones
Rats
Rats, Inbred F344
Reactive Oxygen Species
Rhizome
RNA, Messenger
Superoxide Dismutase
Time Factors
Tumor Necrosis Factor-alpha
Up-Regulation

authors with profiles

Pratibha V. Nerurkar, PhD

RCMI CC is supported by the National Institute on Minority Health and Health Disparities, National Institutes of Health (NIH), through Grant Number U24MD015970. The contents of this site are solely the responsibility of the authors and do not necessarily represent the official views of the NIH

For technical support please contact support