Loss of the bloom syndrome helicase increases DNA ligase 4-independent genome rearrangements and tumorigenesis in aging Drosophila.

Garcia AM, Salomon RN, Witsell A, Liepkalns J, Calder RB, Lee M, Lundell M, Vijg J, McVey M. Loss of the bloom syndrome helicase increases DNA ligase 4-independent genome rearrangements and tumorigenesis in aging Drosophila. Genome Biol. 2011 Dec 19; 12(12):R121.

View in: PubMed

subject areas

Aging
Animals
Cell Transformation, Neoplastic
DNA Breaks, Double-Stranded
DNA Helicases
DNA Ligases
DNA Repair
Drosophila melanogaster
Drosophila Proteins
Genes, Reporter
Genomic Instability
Lac Operon
Mutation

authors with profiles

Martha Lundell

RCMI CC is supported by the National Institute on Minority Health and Health Disparities, National Institutes of Health (NIH), through Grant Number U24MD015970. The contents of this site are solely the responsibility of the authors and do not necessarily represent the official views of the NIH

For technical support please contact support