DNA Breaks, Double-Stranded

"DNA Breaks, Double-Stranded" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus, MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure, which enables searching at various levels of specificity.

MeSH information

Definition | Details | More General Concepts | Related Concepts | More Specific Concepts

Interruptions in the sugar-phosphate backbone of DNA, across both strands adjacently.

Descriptor ID	D053903
MeSH Number(s)	G05.200.210.220
Concept/Terms	DNA Breaks, Double-Stranded DNA Breaks, Double-Stranded Break, Double-Stranded DNA Breaks, Double-Stranded DNA DNA Break, Double-Stranded DNA Breaks, Double Stranded Double-Stranded DNA Break Double Stranded DNA Break Double-Strand DNA Breaks Break, Double-Strand DNA Breaks, Double-Strand DNA DNA Break, Double-Strand DNA Breaks, Double-Strand Double Strand DNA Breaks Double-Strand DNA Break Double-Stranded DNA Breaks Double Stranded DNA Breaks

Below are MeSH descriptors whose meaning is more general than "DNA Breaks, Double-Stranded".

Biological Sciences [G]
Genetic Phenomena [G05]
DNA Damage [G05.200]
DNA Breaks [G05.200.210]
DNA Breaks, Double-Stranded [G05.200.210.220]

Below are MeSH descriptors whose meaning is related to "DNA Breaks, Double-Stranded".

Below are MeSH descriptors whose meaning is more specific than "DNA Breaks, Double-Stranded".

publications

Timeline | Most Recent

This graph shows the total number of publications written about "DNA Breaks, Double-Stranded" by people in this website by year, and whether "DNA Breaks, Double-Stranded" was a major or minor topic of these publications.

Bar chart showing 29 publications over 16 distinct years, with a maximum of 5 publications in 2021

To see the data from this visualization as text, click here.

Year	Major Topic	Minor Topic	Total
2007	1	1	2
2008	1	0	1
2009	1	1	2
2010	1	0	1
2011	0	2	2
2013	3	1	4
2014	0	1	1
2015	0	1	1
2016	0	1	1
2019	0	4	4
2020	1	0	1
2021	4	1	5
2022	0	1	1
2023	0	1	1
2024	0	1	1
2025	0	1	1

Below are the most recent publications written about "DNA Breaks, Double-Stranded" by people in Profiles.

Li H, Chatla S, Liu X, Tian Z, Vekariya U, Wang P, Kim D, Octaviani S, Lian Z, Morton G, Feng Z, Yang D, Sullivan-Reed K, Childers W, Yu X, Chitrala KN, Madzo J, Skorski T, Huang J. ZNF251 haploinsufficiency confers PARP inhibitors resistance in BRCA1-mutated cancer cells through activation of homologous recombination. Cancer Lett. 2025 Mar 31; 613:217505.

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McDonald JT, Kim J, Farmerie L, Johnson ML, Trovao NS, Arif S, Siew K, Tsoy S, Bram Y, Park J, Overbey E, Ryon K, Haltom J, Singh U, Enguita FJ, Zaksas V, Guarnieri JW, Topper M, Wallace DC, Meydan C, Baylin S, Meller R, Muratani M, Porterfield DM, Kaufman B, Mori MA, Walsh SB, Sigaudo-Roussel D, Mebarek S, Bottini M, Marquette CA, Wurtele ES, Schwartz RE, Galeano D, Mason CE, Grabham P, Beheshti A. Space radiation damage rescued by inhibition of key spaceflight associated miRNAs. Nat Commun. 2024 Jun 11; 15(1):4825.

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Sible E, Attaway M, Fiorica G, Michel G, Chaudhuri J, Vuong BQ. Ataxia Telangiectasia Mutated and MSH2 Control Blunt DNA End Joining in Ig Class Switch Recombination. J Immunol. 2023 02 15; 210(4):369-376.

View in: PubMed
Rangsrikitphoti P, Marquez-Garban DC, Pietras RJ, McGowan E, Boonyaratanakornkit V. Sex steroid hormones and DNA repair regulation: Implications on cancer treatment responses. J Steroid Biochem Mol Biol. 2023 03; 227:106230.

View in: PubMed
Darling-Reed SF, Nkrumah-Elie Y, Ferguson DT, Flores-Rozas H, Mendonca P, Messeha S, Hudson A, Badisa RB, Tilghman SL, Womble T, Day A, Jett M, Hammamieh R, Soliman KFA. Diallyl Sulfide Attenuation of Carcinogenesis in Mammary Epithelial Cells through the Inhibition of ROS Formation, and DNA Strand Breaks. Biomolecules. 2021 09 06; 11(9).

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Gillyard T, Davis J. DNA double-strand break repair in cancer: A path to achieving precision medicine. Int Rev Cell Mol Biol. 2021; 364:111-137.

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Mondal T, Nautiyal A, Ghosh S, Loffredo CA, Mitra D, Saha C, Dey SK. An evaluation of DNA double strand break formation and excreted guanine species post whole body PET/CT procedure. J Radiat Res. 2021 Jul 10; 62(4):590-599.

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Noubissi FK, McBride AA, Leppert HG, Millet LJ, Wang X, Davern SM. Detection and quantification of ?-H2AX using a dissociation enhanced lanthanide fluorescence immunoassay. Sci Rep. 2021 04 26; 11(1):8945.

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Mori Y, Ogonuki N, Hasegawa A, Kanatsu-Shinohara M, Ogura A, Wang Y, McCarrey JR, Shinohara T. OGG1 protects mouse spermatogonial stem cells from reactive oxygen species in culture?. Biol Reprod. 2021 03 11; 104(3):706-716.

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Lamboy-Caraballo R, Ortiz-Sanchez C, Acevedo-Santiago A, Matta J, N A Monteiro A, N Armaiz-Pena G. Norepinephrine-Induced DNA Damage in Ovarian Cancer Cells. Int J Mol Sci. 2020 Mar 24; 21(6).

View in: PubMed

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