Therapeutic enzyme deimmunization by combinatorial T-cell epitope removal using neutral drift.

Cantor JR, Yoo TH, Dixit A, Iverson BL, Forsthuber TG, Georgiou G. Therapeutic enzyme deimmunization by combinatorial T-cell epitope removal using neutral drift. Proc Natl Acad Sci U S A. 2011 Jan 25; 108(4):1272-7.

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subject areas

Animals
Asparaginase
Catalytic Domain
Computational Biology
Directed Molecular Evolution
Epitopes, T-Lymphocyte
Escherichia coli Proteins
Female
Flow Cytometry
Genetic Drift
HLA-DR Antigens
Humans
Immunization
Interferon-gamma
Male
Mice
Mice, Transgenic
Models, Molecular
Mutation
Peptide Library
Protein Structure, Tertiary
T-Lymphocytes

authors with profiles

Thomas Forsthuber

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