"Catalytic Domain" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
The region of an enzyme that interacts with its substrate to cause the enzymatic reaction.
| Descriptor ID |
D020134
|
| MeSH Number(s) |
G02.111.570.120.704 G02.111.570.820.709.275.750.188
|
| Concept/Terms |
Catalytic Domain- Catalytic Domain
- Catalytic Domains
- Domain, Catalytic
- Domains, Catalytic
- Catalytic Subunit
- Catalytic Subunits
- Subunit, Catalytic
- Subunits, Catalytic
- Catalytic Region
- Catalytic Regions
- Region, Catalytic
- Regions, Catalytic
- Catalytic Core
- Catalytic Cores
- Core, Catalytic
- Cores, Catalytic
Active Site- Active Site
- Active Sites
- Site, Active
- Sites, Active
- Catalytic Site
- Catalytic Sites
- Site, Catalytic
- Sites, Catalytic
- Reactive Site
- Reactive Sites
- Site, Reactive
- Sites, Reactive
|
Below are MeSH descriptors whose meaning is more general than "Catalytic Domain".
Below are MeSH descriptors whose meaning is more specific than "Catalytic Domain".
This graph shows the total number of publications written about "Catalytic Domain" by people in this website by year, and whether "Catalytic Domain" was a major or minor topic of these publications.
To see the data from this visualization as text,
click here.
| Year | Major Topic | Minor Topic | Total |
|---|
| 1999 | 0 | 1 | 1 |
| 2001 | 0 | 1 | 1 |
| 2002 | 0 | 1 | 1 |
| 2003 | 0 | 3 | 3 |
| 2004 | 1 | 2 | 3 |
| 2005 | 0 | 2 | 2 |
| 2006 | 1 | 3 | 4 |
| 2007 | 0 | 2 | 2 |
| 2008 | 0 | 2 | 2 |
| 2009 | 0 | 5 | 5 |
| 2010 | 0 | 6 | 6 |
| 2011 | 0 | 5 | 5 |
| 2012 | 2 | 7 | 9 |
| 2013 | 0 | 12 | 12 |
| 2014 | 0 | 7 | 7 |
| 2015 | 2 | 8 | 10 |
| 2016 | 0 | 5 | 5 |
| 2017 | 0 | 4 | 4 |
| 2018 | 0 | 4 | 4 |
| 2019 | 1 | 0 | 1 |
| 2020 | 0 | 4 | 4 |
| 2021 | 0 | 1 | 1 |
| 2022 | 0 | 2 | 2 |
| 2023 | 0 | 2 | 2 |
| 2024 | 2 | 1 | 3 |
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click here.
Below are the most recent publications written about "Catalytic Domain" by people in Profiles.
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Shirakawa KT, Parikh T, Machado LESF, Poimenidou G, Nguyen HT, Dell'Acqua ML, Kettenbach AN, Page R, Peti W. The clinical missense variant E282K in PPP3CA/calcineurin shifts substrate dephosphorylation by altering active site recruitment. Nat Commun. 2026 Feb 16; 17(1).
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Piserchio A, Isiorho EA, Abzalimov R, Dalby KN, Ghose R. Phosphorylation of a conserved aspartate in the catalytic site of eukaryotic elongation factor 2 kinase. Protein Sci. 2026 Jan; 35(1):e70442.
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Dumas A, Goyal N, Mottamal M, Afosah DK, Al-Horani RA. Discovery of a new lead molecule to develop a novel class of human factor XIIa inhibitors. J Thromb Thrombolysis. 2024 Dec; 57(8):1308-1314.
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Shen J, Song XW, Bickel D, Rosen BP, Zhao FJ, Messens J, Zhang J. Arsenate reductase of Rufibacter tibetensis is a metallophosphoesterase evolved to catalyze redox reactions. Mol Microbiol. 2024 08; 122(2):201-212.
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Mealka M, Sierra NA, Avellaneda Matteo D, Albekioni E, Khoury R, Mai T, Conley BM, Coleman NJ, Sabo KA, Komives EA, Bobkov AA, Cooksy AL, Silletti S, Schiffer JM, Huxford T, Sohl CD. Active site remodeling in tumor-relevant IDH1 mutants drives distinct kinetic features and potential resistance mechanisms. Nat Commun. 2024 May 06; 15(1):3785.
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Toro TB, Skripnikova EV, Bornes KE, Zhang K, Watt TJ. Endogenous expression of inactive lysine deacetylases reveals deacetylation-dependent cellular mechanisms. PLoS One. 2023; 18(9):e0291779.
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Piserchio A, Isiorho EA, Dalby KN, Ghose R. Structure of the complex between calmodulin and a functional construct of eukaryotic elongation factor 2 kinase bound to an ATP-competitive inhibitor. J Biol Chem. 2023 06; 299(6):104813.
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Nguyen H, Kettenbach AN. Substrate and phosphorylation site selection by phosphoprotein phosphatases. Trends Biochem Sci. 2023 08; 48(8):713-725.
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Transue WJ, Snyder RA, Caranto JD, Kurtz DM, Solomon EI. Particle Swarm Fitting of Spin Hamiltonians: Magnetic Circular Dichroism of Reduced and NO-Bound Flavodiiron Protein. Inorg Chem. 2022 Oct 24; 61(42):16520-16527.
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Al-Horani RA, Parsaeian E, Mohammad M, Mottamal M. Sulfonated non-saccharide molecules and human factor XIa: Enzyme inhibition and computational studies. Chem Biol Drug Des. 2022 07; 100(1):64-79.