DNA adducts of decarbamoyl mitomycin C efficiently kill cells without wild-type p53 resulting from proteasome-mediated degradation of checkpoint protein 1.

Boamah EK, Brekman A, Tomasz M, Myeku N, Figueiredo-Pereira M, Hunter S, Meyer J, Bhosle RC, Bargonetti J. DNA adducts of decarbamoyl mitomycin C efficiently kill cells without wild-type p53 resulting from proteasome-mediated degradation of checkpoint protein 1. Chem Res Toxicol. 2010 Jul 19; 23(7):1151-62.

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subject areas

Apoptosis
Cell Line, Tumor
DNA Adducts
DNA Damage
Gene Silencing
Humans
Mitomycin
Mitomycins
Proteasome Endopeptidase Complex
Protein Kinases
RNA Interference
RNA, Small Interfering
Tumor Suppressor Protein p53

authors with profiles

Jill Bargonetti
Maria Figueiredo-Pereira

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