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Karunya Kandimalla

TitleAssociate Professor
InstitutionFlorida A&M University
DepartmentPharmaceutical Sciences
Address228 Dyson Pharmacy Building
1520 MLK Jr. Blvd.
College of Pharmacy and Pharmaceutical Sciences
Tallahassee FL 32301
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    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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    PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. Nelson D, Thompson KJ, Wang L, Wang Z, Eberts P, Azarin SM, Kalari KR, Kandimalla KK. Pericyte Control of Gene Expression in the Blood-Brain Barrier Endothelium: Implications for Alzheimer's Disease. J Alzheimers Dis. 2024 Feb 19. PMID: 38393902.
      Citations:    Fields:    
    2. Wang Z, Sharda N, Omtri RS, Li L, Kandimalla KK. Amyloid-Beta Peptides 40 and 42 Employ Distinct Molecular Pathways for Cell Entry and Intracellular Transit at the Blood-Brain Barrier Endothelium. Mol Pharmacol. 2023 Nov; 104(5):203-213. PMID: 37541759.
      Citations:    Fields:    Translation:HumansCells
    3. Wang Z, Tang X, Swaminathan SK, Kandimalla KK, Kalari KR. Mapping the dynamics of insulin-responsive pathways in the blood-brain barrier endothelium using time-series transcriptomics data. NPJ Syst Biol Appl. 2022 08 16; 8(1):29. PMID: 35974022.
      Citations: 3     Fields:    Translation:HumansCells
    4. Wang L, Wiedmann TS, Kandimalla KK. Modulating insulin signaling and trafficking at the blood-brain barrier endothelium using lipid based nanoemulsions. Int J Pharm. 2022 Jun 25; 622:121823. PMID: 35605891.
      Citations:    Fields:    Translation:HumansCells
    5. Zhou AL, Sharda N, Sarma VV, Ahlschwede KM, Curran GL, Tang X, Poduslo JF, Kalari KR, Lowe VJ, Kandimalla KK. Age-Dependent Changes in the Plasma and Brain Pharmacokinetics of Amyloid-? Peptides and Insulin. J Alzheimers Dis. 2022; 85(3):1031-1044. PMID: 34924382.
      Citations: 5     Fields:    Translation:Animals
    6. Wang Z, Sharda N, Curran GL, Li L, Lowe VJ, Kandimalla KK. Semimechanistic Population Pharmacokinetic Modeling to Investigate Amyloid Beta Trafficking and Accumulation at the BBB Endothelium. Mol Pharm. 2021 11 01; 18(11):4148-4161. PMID: 34664956.
      Citations: 2     Fields:    Translation:HumansAnimalsCells
    7. Salian VS, Wright JA, Vedell PT, Nair S, Li C, Kandimalla M, Tang X, Carmona Porquera EM, Kalari KR, Kandimalla KK. COVID-19 Transmission, Current Treatment, and Future Therapeutic Strategies. Mol Pharm. 2021 03 01; 18(3):754-771. PMID: 33464914.
      Citations: 100     Fields:    Translation:HumansCells
    8. Sharda N, Ahlschwede KM, Curran GL, Lowe VJ, Kandimalla KK. Distinct Uptake Kinetics of Alzheimer Disease Amyloid-? 40 and 42 at the Blood-Brain Barrier Endothelium. J Pharmacol Exp Ther. 2021 03; 376(3):482-490. PMID: 33303699.
      Citations: 7     Fields:    Translation:HumansCells
    9. Swaminathan SK, Zhou AL, Ahlschwede KM, Curran GL, Lowe VJ, Li L, Kandimalla KK. High-Density Lipoprotein Mimetic Peptide 4F Efficiently Crosses the Blood-Brain Barrier and Modulates Amyloid-? Distribution between Brain and Plasma. J Pharmacol Exp Ther. 2020 11; 375(2):308-316. PMID: 32778535.
      Citations: 6     Fields:    Translation:Animals
    10. Sharda N, Pengo T, Wang Z, Kandimalla KK. Amyloid-? Peptides Disrupt Interactions Between VAMP-2 and SNAP-25 in Neuronal Cells as Determined by FRET/FLIM. J Alzheimers Dis. 2020; 77(1):423-435. PMID: 32675412.
      Citations: 6     Fields:    Translation:HumansCells
    11. Gali CC, Fanaee-Danesh E, Zandl-Lang M, Albrecher NM, Tam-Amersdorfer C, Stracke A, Sachdev V, Reichmann F, Sun Y, Avdili A, Reiter M, Kratky D, Holzer P, Lass A, Kandimalla KK, Panzenboeck U. Amyloid-beta impairs insulin signaling by accelerating autophagy-lysosomal degradation of LRP-1 and IR-? in blood-brain barrier endothelial cells in vitro and in 3XTg-AD mice. Mol Cell Neurosci. 2019 09; 99:103390. PMID: 31276749.
      Citations: 30     Fields:    Translation:HumansAnimalsCells
    12. Zhou AL, Swaminathan SK, Curran GL, Poduslo JF, Lowe VJ, Li L, Kandimalla KK. Apolipoprotein A-I Crosses the Blood-Brain Barrier through Clathrin-Independent and Cholesterol-Mediated Endocytosis. J Pharmacol Exp Ther. 2019 06; 369(3):481-488. PMID: 30971477.
      Citations: 24     Fields:    Translation:HumansAnimals
    13. Ahlschwede KM, Curran GL, Rosenberg JT, Grant SC, Sarkar G, Jenkins RB, Ramakrishnan S, Poduslo JF, Kandimalla KK. Cationic carrier peptide enhances cerebrovascular targeting of nanoparticles in Alzheimer's disease brain. Nanomedicine. 2019 02; 16:258-266. PMID: 30300748.
      Citations: 11     Fields:    Translation:HumansAnimalsCells
    14. Swaminathan SK, Fisher J, Brogden NK, Kandimalla KK. Development and validation of a sensitive LC-MS/MS method for the estimation of scopolamine in human serum. J Pharm Biomed Anal. 2019 Feb 05; 164:41-46. PMID: 30396054.
      Citations:    Fields:    Translation:Humans
    15. Omtri RS, Thompson KJ, Tang X, Gali CC, Panzenboeck U, Davidson MW, Kalari KR, Kandimalla KK. Differential Effects of Alzheimer's Disease A?40 and 42 on Endocytosis and Intraneuronal Trafficking. Neuroscience. 2018 03 01; 373:159-168. PMID: 29337241.
      Citations: 6     Fields:    Translation:HumansAnimalsCells
    16. Thompson KJ, Ingle JN, Tang X, Chia N, Jeraldo PR, Walther-Antonio MR, Kandimalla KK, Johnson S, Yao JZ, Harrington SC, Suman VJ, Wang L, Weinshilboum RL, Boughey JC, Kocher JP, Nelson H, Goetz MP, Kalari KR. A comprehensive analysis of breast cancer microbiota and host gene expression. PLoS One. 2017; 12(11):e0188873. PMID: 29190829.
      Citations: 69     Fields:    Translation:HumansCells
    17. Swaminathan SK, Ahlschwede KM, Sarma V, Curran GL, Omtri RS, Decklever T, Lowe VJ, Poduslo JF, Kandimalla KK. Insulin differentially affects the distribution kinetics of amyloid beta 40 and 42 in plasma and brain. J Cereb Blood Flow Metab. 2018 05; 38(5):904-918. PMID: 28569090.
      Citations: 21     Fields:    Translation:HumansAnimalsCells
    18. Agyare EK, Jaruszewski KM, Curran GL, Rosenberg JT, Grant SC, Lowe VJ, Ramakrishnan S, Paravastu AK, Poduslo JF, Kandimalla KK. Engineering theranostic nanovehicles capable of targeting cerebrovascular amyloid deposits. J Control Release. 2014 Jul 10; 185:121-9. PMID: 24735640.
      Citations: 20     Fields:    Translation:HumansAnimalsCells
    19. Jaruszewski KM, Curran GL, Swaminathan SK, Rosenberg JT, Grant SC, Ramakrishnan S, Lowe VJ, Poduslo JF, Kandimalla KK. Multimodal nanoprobes to target cerebrovascular amyloid in Alzheimer's disease brain. Biomaterials. 2014 Feb; 35(6):1967-76. PMID: 24331706.
      Citations: 19     Fields:    Translation:HumansAnimalsCells
    20. Kandimalla KK, Borden E, Omtri RS, Boyapati SP, Smith M, Lebby K, Mulpuru M, Gadde M. Ability of chitosan gels to disrupt bacterial biofilms and their applications in the treatment of bacterial vaginosis. J Pharm Sci. 2013 Jul; 102(7):2096-101. PMID: 23695992.
      Citations: 13     Fields:    Translation:HumansCells
    21. Agyare EK, Leonard SR, Curran GL, Yu CC, Lowe VJ, Paravastu AK, Poduslo JF, Kandimalla KK. Traffic jam at the blood-brain barrier promotes greater accumulation of Alzheimer's disease amyloid-? proteins in the cerebral vasculature. Mol Pharm. 2013 May 06; 10(5):1557-65. PMID: 23249146.
      Citations: 11     Fields:    Translation:HumansAnimalsCells
    22. Omtri RS, Davidson MW, Arumugam B, Poduslo JF, Kandimalla KK. Differences in the cellular uptake and intracellular itineraries of amyloid beta proteins 40 and 42: ramifications for the Alzheimer's drug discovery. Mol Pharm. 2012 Jul 02; 9(7):1887-97. PMID: 22574751.
      Citations: 26     Fields:    Translation:AnimalsCells
    23. Poduslo JF, Howell KG, Olson NC, Ramirez-Alvarado M, Kandimalla KK. Alzheimer's disease amyloid ?-protein mutations and deletions that define neuronal binding/internalization as early stage nonfibrillar/fibrillar aggregates and late stage fibrils. Biochemistry. 2012 May 15; 51(19):3993-4003. PMID: 22545812.
      Citations: 10     Fields:    Translation:HumansAnimalsCells
    24. Jaruszewski KM, Ramakrishnan S, Poduslo JF, Kandimalla KK. Chitosan enhances the stability and targeting of immuno-nanovehicles to cerebro-vascular deposits of Alzheimer's disease amyloid protein. Nanomedicine. 2012 Feb; 8(2):250-60. PMID: 21704598.
      Citations: 19     Fields:    Translation:Humans
    25. Poduslo JF, Gilles EJ, Ramakrishnan M, Howell KG, Wengenack TM, Curran GL, Kandimalla KK. HH domain of Alzheimer's disease Abeta provides structural basis for neuronal binding in PC12 and mouse cortical/hippocampal neurons. PLoS One. 2010 Jan 21; 5(1):e8813. PMID: 20098681.
      Citations: 10     Fields:    Translation:AnimalsCells
    26. Kandimalla KK, Babu RJ, Singh M. Biphasic flux profiles of melatonin: the Yin-Yang of transdermal permeation enhancement mediated by fatty alcohol enhancers. J Pharm Sci. 2010 Jan; 99(1):209-18. PMID: 19530074.
      Citations:    Fields:    Translation:AnimalsCells
    27. Ramakrishnan M, Kandimalla KK, Wengenack TM, Howell KG, Poduslo JF. Surface plasmon resonance binding kinetics of Alzheimer's disease amyloid beta peptide-capturing and plaque-binding monoclonal antibodies. Biochemistry. 2009 Nov 03; 48(43):10405-15. PMID: 19775170.
      Citations: 23     Fields:    Translation:AnimalsCells
    28. Kandimalla KK, Scott OG, Fulzele S, Davidson MW, Poduslo JF. Mechanism of neuronal versus endothelial cell uptake of Alzheimer's disease amyloid beta protein. PLoS One. 2009; 4(2):e4627. PMID: 19247480.
      Citations: 39     Fields:    Translation:AnimalsCells
    29. Agyare EK, Curran GL, Ramakrishnan M, Yu CC, Poduslo JF, Kandimalla KK. Development of a smart nano-vehicle to target cerebrovascular amyloid deposits and brain parenchymal plaques observed in Alzheimer's disease and cerebral amyloid angiopathy. Pharm Res. 2008 Nov; 25(11):2674-84. PMID: 18712585.
      Citations: 23     Fields:    Translation:AnimalsCells
    30. Ramakrishnan M, Wengenack TM, Kandimalla KK, Curran GL, Gilles EJ, Ramirez-Alvarado M, Lin J, Garwood M, Jack CR, Poduslo JF. Selective contrast enhancement of individual Alzheimer's disease amyloid plaques using a polyamine and Gd-DOTA conjugated antibody fragment against fibrillar Abeta42 for magnetic resonance molecular imaging. Pharm Res. 2008 Aug; 25(8):1861-72. PMID: 18443900.
      Citations: 18     Fields:    Translation:HumansAnimals
    31. Poduslo JF, Ramakrishnan M, Holasek SS, Ramirez-Alvarado M, Kandimalla KK, Gilles EJ, Curran GL, Wengenack TM. In vivo targeting of antibody fragments to the nervous system for Alzheimer's disease immunotherapy and molecular imaging of amyloid plaques. J Neurochem. 2007 Jul; 102(2):420-33. PMID: 17596213.
      Citations: 34     Fields:    Translation:HumansAnimalsCells
    32. Kandimalla KK, Wengenack TM, Curran GL, Gilles EJ, Poduslo JF. Pharmacokinetics and amyloid plaque targeting ability of a novel peptide-based magnetic resonance contrast agent in wild-type and Alzheimer's disease transgenic mice. J Pharmacol Exp Ther. 2007 Aug; 322(2):541-9. PMID: 17505020.
      Citations: 4     Fields:    Translation:HumansAnimals
    33. Kandimalla KK, Curran GL, Holasek SS, Gilles EJ, Wengenack TM, Ramirez-Alvarado M, Poduslo JF. Physiological and biophysical factors that influence Alzheimer's disease amyloid plaque targeting of native and putrescine modified human amyloid beta40. J Pharmacol Exp Ther. 2006 Jul; 318(1):17-25. PMID: 16565169.
      Citations: 3     Fields:    Translation:HumansAnimals
    34. Kandimalla KK, Donovan MD. Transport of hydroxyzine and triprolidine across bovine olfactory mucosa: role of passive diffusion in the direct nose-to-brain uptake of small molecules. Int J Pharm. 2005 Sep 30; 302(1-2):133-44. PMID: 16105724.
      Citations: 3     Fields:    Translation:AnimalsCells
    35. Holasek SS, Wengenack TM, Kandimalla KK, Montano C, Gregor DM, Curran GL, Poduslo JF. Activation of the stress-activated MAP kinase, p38, but not JNK in cortical motor neurons during early presymptomatic stages of amyotrophic lateral sclerosis in transgenic mice. Brain Res. 2005 May 31; 1045(1-2):185-98. PMID: 15910777.
      Citations: 26     Fields:    Translation:HumansAnimalsCells
    36. Kandimalla KK, Curran GL, Holasek SS, Gilles EJ, Wengenack TM, Poduslo JF. Pharmacokinetic analysis of the blood-brain barrier transport of 125I-amyloid beta protein 40 in wild-type and Alzheimer's disease transgenic mice (APP,PS1) and its implications for amyloid plaque formation. J Pharmacol Exp Ther. 2005 Jun; 313(3):1370-8. PMID: 15743932.
      Citations: 22     Fields:    Translation:HumansAnimals
    37. Kandimalla KK, Donovan MD. Carrier mediated transport of chlorpheniramine and chlorcyclizine across bovine olfactory mucosa: implications on nose-to-brain transport. J Pharm Sci. 2005 Mar; 94(3):613-24. PMID: 15666293.
      Citations: 11     Fields:    Translation:Animals
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