Cyclic Nucleotide Phosphodiesterases, Type 4

"Cyclic Nucleotide Phosphodiesterases, Type 4" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus, MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure, which enables searching at various levels of specificity.

MeSH information

Definition | Details | More General Concepts | Related Concepts | More Specific Concepts

A cyclic nucleotide phosphodiesterase subfamily that is found predominantly in inflammatory cells and may play a role in the regulation of CELL-MEDIATED IMMUNITY. The enzyme family includes over twenty different variants that occur due to multiple ALTERNATIVE SPLICING of the mRNA of at least four different genes.

Descriptor ID	D054703
MeSH Number(s)	D08.811.277.352.640.150.400 D12.644.360.008.400 D12.776.476.008.400
Concept/Terms	Cyclic Nucleotide Phosphodiesterases, Type 4 Cyclic Nucleotide Phosphodiesterases, Type 4 Phosphodiesterase-4 Phosphodiesterase IV PDE4 Phosphodiesterases Phosphodiesterases, PDE4 Cyclic Nucleotide Phosphodiesterase PDE4 Family Phosphodiesterase 4 Type 4 Cyclic Nucleotide Phosphodiesterase Cyclic Nucleotide Phosphodiesterases, Type 4A5 Cyclic Nucleotide Phosphodiesterases, Type 4A5 cAMP-Specific Phosphodiesterase 4A5 Phosphodiesterase 4A5, cAMP-Specific cAMP Specific Phosphodiesterase 4A5 Cyclic Nucleotide Phosphodiesterases, Type 4D3 Cyclic Nucleotide Phosphodiesterases, Type 4D3 PDE4D3 Phosphodiesterase Phosphodiesterase, PDE4D3 Cyclic Nucleotide Phosphodiesterases, Type 4C Cyclic Nucleotide Phosphodiesterases, Type 4C Phosphodiesterase 4C Cyclic Nucleotide Phosphodiesterases, Type 4D Cyclic Nucleotide Phosphodiesterases, Type 4D Phosphodiesterase 4D Cyclic Nucleotide Phosphodiesterases, Type 4A Cyclic Nucleotide Phosphodiesterases, Type 4A Phosphodiesterase 4A Cyclic Nucleotide Phosphodiesterases, Type 4B Cyclic Nucleotide Phosphodiesterases, Type 4B Phosphodiesterase 4B

Below are MeSH descriptors whose meaning is more general than "Cyclic Nucleotide Phosphodiesterases, Type 4".

Chemicals and Drugs [D]
Enzymes and Coenzymes [D08]
Enzymes [D08.811]
Hydrolases [D08.811.277]
Esterases [D08.811.277.352]
Phosphoric Diester Hydrolases [D08.811.277.352.640]
3',5'-Cyclic-AMP Phosphodiesterases [D08.811.277.352.640.150]
Cyclic Nucleotide Phosphodiesterases, Type 4 [D08.811.277.352.640.150.400]
Amino Acids, Peptides, and Proteins [D12]
Peptides [D12.644]
Intracellular Signaling Peptides and Proteins [D12.644.360]
3',5'-Cyclic-AMP Phosphodiesterases [D12.644.360.008]
Cyclic Nucleotide Phosphodiesterases, Type 4 [D12.644.360.008.400]
Proteins [D12.776]
Intracellular Signaling Peptides and Proteins [D12.776.476]
3',5'-Cyclic-AMP Phosphodiesterases [D12.776.476.008]
Cyclic Nucleotide Phosphodiesterases, Type 4 [D12.776.476.008.400]

Below are MeSH descriptors whose meaning is related to "Cyclic Nucleotide Phosphodiesterases, Type 4".

Below are MeSH descriptors whose meaning is more specific than "Cyclic Nucleotide Phosphodiesterases, Type 4".

publications

Timeline | Most Recent

This graph shows the total number of publications written about "Cyclic Nucleotide Phosphodiesterases, Type 4" by people in this website by year, and whether "Cyclic Nucleotide Phosphodiesterases, Type 4" was a major or minor topic of these publications.

Bar chart showing 8 publications over 6 distinct years, with a maximum of 3 publications in 2013

To see the data from this visualization as text, click here.

Year	Major Topic	Minor Topic	Total
1998	0	1	1
2003	0	1	1
2005	0	1	1
2008	0	1	1
2012	1	0	1
2013	2	1	3

Below are the most recent publications written about "Cyclic Nucleotide Phosphodiesterases, Type 4" by people in Profiles.

Anthony EG, Richard E, Lipkowitz MS, Kelley ST, Alcaraz JE, Shaffer RA, Bhatnagar V. Association of phosphodiesterase 4 polymorphism (rs702553) with blood pressure in the African American Study of Kidney Disease and Hypertension Genomics Study. Pharmacogenet Genomics. 2013 Aug; 23(8):442-4.

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Lin DC, Xu L, Ding LW, Sharma A, Liu LZ, Yang H, Tan P, Vadgama J, Karlan BY, Lester J, Urban N, Schummer M, Doan N, Said JW, Sun H, Walsh M, Thomas CJ, Patel P, Yin D, Chan D, Koeffler HP. Genomic and functional characterizations of phosphodiesterase subtype 4D in human cancers. Proc Natl Acad Sci U S A. 2013 Apr 09; 110(15):6109-14.

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Yadav S, Hasan N, Marjot T, Khan MS, Prasad K, Bentley P, Sharma P. Detailed analysis of gene polymorphisms associated with ischemic stroke in South Asians. PLoS One. 2013; 8(3):e57305.

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Nagy ZS, Ross JA, Rodriguez G, Balint BL, Szeles L, Nagy L, Kirken RA. Genome wide mapping reveals PDE4B as an IL-2 induced STAT5 target gene in activated human PBMCs and lymphoid cancer cells. PLoS One. 2013; 8(2):e57326.

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Freund YR, Akama T, Alley MR, Antunes J, Dong C, Jarnagin K, Kimura R, Nieman JA, Maples KR, Plattner JJ, Rock F, Sharma R, Singh R, Sanders V, Zhou Y. Boron-based phosphodiesterase inhibitors show novel binding of boron to PDE4 bimetal center. FEBS Lett. 2012 Sep 21; 586(19):3410-4.

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Ebalunode JO, Ouyang Z, Liang J, Zheng W. Novel approach to structure-based pharmacophore search using computational geometry and shape matching techniques. J Chem Inf Model. 2008 Apr; 48(4):889-901.

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Anderson AJ, Nicholson JM, Bakare O, Butcher RJ, Wilson TL, Scott KR. Enaminones 9. Further studies on the anticonvulsant activity and potential type IV phosphodiesterase inhibitory activity of substituted vinylic benzamides. Bioorg Med Chem. 2006 Feb 15; 14(4):997-1006.

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Singh SP, Barrett EG, Kalra R, Razani-Boroujerdi S, Langley RJ, Kurup V, Tesfaigzi Y, Sopori ML. Prenatal cigarette smoke decreases lung cAMP and increases airway hyperresponsiveness. Am J Respir Crit Care Med. 2003 Aug 01; 168(3):342-7.

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Crocker IC, Ohia SE, Church MK, Townley RG. Phosphodiesterase type 4 inhibitors, but not glucocorticoids, are more potent in suppression of cytokine secretion by mononuclear cells from atopic than nonatopic donors. J Allergy Clin Immunol. 1998 Nov; 102(5):797-804.

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