Receptors, G-Protein-Coupled

"Receptors, G-Protein-Coupled" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus, MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure, which enables searching at various levels of specificity.

MeSH information

Definition | Details | More General Concepts | Related Concepts | More Specific Concepts

The largest family of cell surface receptors involved in SIGNAL TRANSDUCTION. They share a common structure and signal through HETEROTRIMERIC G-PROTEINS.

Descriptor ID	D043562
MeSH Number(s)	D12.776.543.750.695
Concept/Terms	Receptors, G-Protein-Coupled Receptors, G-Protein-Coupled Receptors, G Protein Coupled G-Protein-Coupled Receptors G Protein Coupled Receptors

Below are MeSH descriptors whose meaning is more general than "Receptors, G-Protein-Coupled".

Chemicals and Drugs [D]
Amino Acids, Peptides, and Proteins [D12]
Proteins [D12.776]
Membrane Proteins [D12.776.543]
Receptors, Cell Surface [D12.776.543.750]
Receptors, G-Protein-Coupled [D12.776.543.750.695]

Below are MeSH descriptors whose meaning is related to "Receptors, G-Protein-Coupled".

Below are MeSH descriptors whose meaning is more specific than "Receptors, G-Protein-Coupled".

publications

Timeline | Most Recent

This graph shows the total number of publications written about "Receptors, G-Protein-Coupled" by people in this website by year, and whether "Receptors, G-Protein-Coupled" was a major or minor topic of these publications.

Bar chart showing 79 publications over 25 distinct years, with a maximum of 7 publications in 2021

To see the data from this visualization as text, click here.

Year	Major Topic	Minor Topic	Total
1999	1	0	1
2000	1	0	1
2001	1	2	3
2002	0	1	1
2004	3	2	5
2005	1	0	1
2006	1	0	1
2007	1	2	3
2008	1	1	2
2009	0	1	1
2010	0	4	4
2011	1	2	3
2012	3	1	4
2013	4	1	5
2014	4	2	6
2015	1	2	3
2016	1	0	1
2017	3	2	5
2018	3	3	6
2019	1	1	2
2020	2	3	5
2021	7	0	7
2022	1	1	2
2024	4	2	6
2025	1	0	1

Below are the most recent publications written about "Receptors, G-Protein-Coupled" by people in Profiles.

Cichy A, Dewan A, He Z, Fitzgerald C, Ratkowski M, Krasewicz J, Ozarkar V, Kaye S, Teng T, Zhang J, Feinstein P, Bozza T. A microbiome-derived olfactory signal regulates inter-male aggression and social dominance in mice. Curr Biol. 2026 Apr 20; 36(8):1946-1958.e4.

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da Silva RAG, Tien BYQ, Kao PHN, Antypas H, Celik C, Tan AZC, Ismail MH, Hu G, Chong KKL, Thibault G, Chen J, Kline KA. Enterococcus faecalis-derived lactic acid suppresses macrophage activation to facilitate persistent and polymicrobial wound infections. Cell Host Microbe. 2026 Feb 11; 34(2):245-262.e8.

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Lu A, Agsalda-Garcia M, Hu W, Chester C, Naik AA, Mitchell BI, Asante I, Souza SA, Lian KC, Zhang Z, Schmitz HV, Ramirez ML, Varshney R, DelMundo S, Chow DC, Shikuma CM, Louie SG. Telmisartan reduces systemic inflammation and alters the renin-angiotensin system in mild COVID-19. Sci Rep. 2025 Dec 03; 16(1):720.

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Kiaei N, Malik A, Idahosa SO, Lee KK, Endo-Umeda K, Makishima M, Kawamura A, Higuchi S. Python-derived 16a-Hydroxylated Bile Acid, Pythocholic Acid is a ligand for TGR5, not farnesoid X receptors and vitamin D receptors. Biochem Biophys Res Commun. 2025 03 05; 751:151453.

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He Q, Zhou Y, Wu L, Huang L, Yuan Y, Flores JJ, Luo X, Tao Y, Chen X, Kanamaru H, Dong S, Zhu S, Yu Q, Han M, Sherchan P, Li J, Tang J, Xie Z, Zhang JH. Inhibition of acid-sensing receptor GPR4 attenuates neuronal ferroptosis via RhoA/YAP signaling in a rat model of subarachnoid hemorrhage. Free Radic Biol Med. 2024 Nov 20; 225:333-345.

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Hanafi D, Onyenwoke RU, Kimbro KS. The G-Protein-Coupled Estrogen Receptor Selective Agonist G-1 Attenuates Cell Viability and Migration in High-Grade Serous Ovarian Cancer Cell Lines. Int J Mol Sci. 2024 Jun 13; 25(12).

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Hixon JC, Rivas Zarete JI, White J, Hilaire M, Muhammad A, Yusuf AP, Adu-Addai B, Yates CC, Mahavadi S. Epigenetic Modulation of GPER Expression in Gastric and Colonic Smooth Muscle of Male and Female Non-Obese Diabetic (NOD) Mice: Insights into H3K4me3 and H3K27ac Modifications. Int J Mol Sci. 2024 May 11; 25(10).

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Muhammad A, Hixon JC, Pharmacy Yusuf A, Rivas Zarete JI, Johnson I, Miller J, Adu-Addai B, Yates C, Mahavadi S. Sex-specific epigenetics drive low GPER expression in gastrointestinal smooth muscles in type 2 diabetic mice. Sci Rep. 2024 03 07; 14(1):5633.

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Huang BZ, Binder AM, Quon B, Patel YM, Lum-Jones A, Tiirikainen M, Murphy SE, Loo L, Maunakea AK, Haiman CA, Wilkens LR, Koh WP, Cai Q, Aldrich MC, Siegmund KD, Hecht SS, Yuan JM, Blot WJ, Stram DO, Le Marchand L, Park SL. Epigenome-wide association study of total nicotine equivalents in multiethnic current smokers from three prospective cohorts. Am J Hum Genet. 2024 03 07; 111(3):456-472.

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Dankwah KO, Mohl JE, Begum K, Leung MY. What Makes GPCRs from Different Families Bind to the Same Ligand? Biomolecules. 2022 06 21; 12(7).

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